Cytochrome 4Z1 Expression Is Correlated with Poor Prognosis in Patients with Cervical Cancer
Background: cervical cancer is one of the most common malignancies in women worldwide and its management remains challenging and complex. As Cytochrome4Z1 (CYP4Z1) is overexpressed in many tumours, its expression in cervical cancer is unknown. Therefore, the present study aimed to evaluate CYP4Z1 ex...
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| Format: | Article |
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MDPI AG
2021-09-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/28/5/306 |
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| author | Yousef M. Al-saraireh Fatemah O. F. O. Alshammari Ahmed M. M. Youssef Yahya M. Al-sarayra Renata A. Al-saraireh Ghadeer H. Al-muhaisen Yanal S. Al-mahdy Ahlam M. Al-Kharabsheh Seham M. Abufraijeh Hamzeh Mohammad Alrawashdeh |
| author_facet | Yousef M. Al-saraireh Fatemah O. F. O. Alshammari Ahmed M. M. Youssef Yahya M. Al-sarayra Renata A. Al-saraireh Ghadeer H. Al-muhaisen Yanal S. Al-mahdy Ahlam M. Al-Kharabsheh Seham M. Abufraijeh Hamzeh Mohammad Alrawashdeh |
| author_sort | Yousef M. Al-saraireh |
| collection | DOAJ |
| description | Background: cervical cancer is one of the most common malignancies in women worldwide and its management remains challenging and complex. As Cytochrome4Z1 (CYP4Z1) is overexpressed in many tumours, its expression in cervical cancer is unknown. Therefore, the present study aimed to evaluate CYP4Z1 expression in cervical cancers. Methods: CYP4Z1 expression was immunohistochemically assessed in 100 cases of cervical cancers along with ten normal cervix tissues, and the enzyme’s relationship to several clinicopathological features and survival was explored. Results: CYP4Z1 was strongly expressed in 55% of cervical cancer patients. Normal cervix samples were negative for CYP4Z1 expression. Importantly, this expression was significantly found in patients with the late stage of the disease, lymph node metastasis, and high tumour invasion (<i>p</i> < 0.05). Interestingly, CYP4Z1 expression was significantly correlated with shorter survival times of cervical cancer patients. Univariate analysis showed that CYP4Z1 expression, tumour stage, lymph node metastasis, and tumour invasion were significantly correlated with patient survival (<i>p</i> < 0.05). The multivariate analysis revealed that only CYP4Z1 expression and tumour stage were significantly correlated with patient survival (<i>p</i> < 0.05). Conclusions: CYP4Z1 expression is associated with cervical cancer patients’ survival and may serve as an independent predictor of poor prognosis in cervical cancer patients. |
| first_indexed | 2024-03-10T06:37:31Z |
| format | Article |
| id | doaj.art-665d14cda1ab49a4aeee05462d0640db |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-10T06:37:31Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-665d14cda1ab49a4aeee05462d0640db2023-11-22T17:54:42ZengMDPI AGCurrent Oncology1198-00521718-77292021-09-012853573358410.3390/curroncol28050306Cytochrome 4Z1 Expression Is Correlated with Poor Prognosis in Patients with Cervical CancerYousef M. Al-saraireh0Fatemah O. F. O. Alshammari1Ahmed M. M. Youssef2Yahya M. Al-sarayra3Renata A. Al-saraireh4Ghadeer H. Al-muhaisen5Yanal S. Al-mahdy6Ahlam M. Al-Kharabsheh7Seham M. Abufraijeh8Hamzeh Mohammad Alrawashdeh9Department of Pharmacology, Faculty of Medicine, Mutah University, P.O. Box 7, Al-Karak 61710, JordanDepartment of Medical Lab Technology, Faculty of Health Sciences, The Public Authority for Applied Education and Training, Shuwaikh 15432, KuwaitDepartment of Pharmacology, Faculty of Pharmacy, Mutah University, P.O. Box 7, Al-Karak 61710, JordanAl-karak Governmental Hospital, Ministry of Health, P.O. Box 86, Al-Karak 11118, JordanAl-karak Governmental Hospital, Ministry of Health, P.O. Box 86, Al-Karak 11118, JordanDepartment of Microbiology and Pathology, Faculty of Medicine, Mutah University, P.O. Box 7, Al-Karak 61710, JordanDepartment of Clinical Sciences, Faculty of Medicine, Mutah University, P.O. Box 7, Al-Karak 61710, JordanDepartment of Obstetrics and Gynecology, Faculty of Medicine, Mutah University, P.O. Box 7, Al-Karak 61710, JordanDepartment of Obstetrics and Gynecology, Faculty of Medicine, Mutah University, P.O. Box 7, Al-Karak 61710, JordanDepartment of Ophthalmology, Sharif Eye Centers, Irbid 410739, JordanBackground: cervical cancer is one of the most common malignancies in women worldwide and its management remains challenging and complex. As Cytochrome4Z1 (CYP4Z1) is overexpressed in many tumours, its expression in cervical cancer is unknown. Therefore, the present study aimed to evaluate CYP4Z1 expression in cervical cancers. Methods: CYP4Z1 expression was immunohistochemically assessed in 100 cases of cervical cancers along with ten normal cervix tissues, and the enzyme’s relationship to several clinicopathological features and survival was explored. Results: CYP4Z1 was strongly expressed in 55% of cervical cancer patients. Normal cervix samples were negative for CYP4Z1 expression. Importantly, this expression was significantly found in patients with the late stage of the disease, lymph node metastasis, and high tumour invasion (<i>p</i> < 0.05). Interestingly, CYP4Z1 expression was significantly correlated with shorter survival times of cervical cancer patients. Univariate analysis showed that CYP4Z1 expression, tumour stage, lymph node metastasis, and tumour invasion were significantly correlated with patient survival (<i>p</i> < 0.05). The multivariate analysis revealed that only CYP4Z1 expression and tumour stage were significantly correlated with patient survival (<i>p</i> < 0.05). Conclusions: CYP4Z1 expression is associated with cervical cancer patients’ survival and may serve as an independent predictor of poor prognosis in cervical cancer patients.https://www.mdpi.com/1718-7729/28/5/306cancercervical cancercytochrome P450cytochrome4z1immunohistochemistry |
| spellingShingle | Yousef M. Al-saraireh Fatemah O. F. O. Alshammari Ahmed M. M. Youssef Yahya M. Al-sarayra Renata A. Al-saraireh Ghadeer H. Al-muhaisen Yanal S. Al-mahdy Ahlam M. Al-Kharabsheh Seham M. Abufraijeh Hamzeh Mohammad Alrawashdeh Cytochrome 4Z1 Expression Is Correlated with Poor Prognosis in Patients with Cervical Cancer Current Oncology cancer cervical cancer cytochrome P450 cytochrome4z1 immunohistochemistry |
| title | Cytochrome 4Z1 Expression Is Correlated with Poor Prognosis in Patients with Cervical Cancer |
| title_full | Cytochrome 4Z1 Expression Is Correlated with Poor Prognosis in Patients with Cervical Cancer |
| title_fullStr | Cytochrome 4Z1 Expression Is Correlated with Poor Prognosis in Patients with Cervical Cancer |
| title_full_unstemmed | Cytochrome 4Z1 Expression Is Correlated with Poor Prognosis in Patients with Cervical Cancer |
| title_short | Cytochrome 4Z1 Expression Is Correlated with Poor Prognosis in Patients with Cervical Cancer |
| title_sort | cytochrome 4z1 expression is correlated with poor prognosis in patients with cervical cancer |
| topic | cancer cervical cancer cytochrome P450 cytochrome4z1 immunohistochemistry |
| url | https://www.mdpi.com/1718-7729/28/5/306 |
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