Low-density lipoprotein balances T cell metabolism and enhances response to anti-PD-1 blockade in a HCT116 spheroid model

Low-density lipoprotein balances T cell metabolism and enhances response to anti-PD-1 blockade in a HCT116 spheroid model

IntroductionThe discovery of immune checkpoints and the development of their specific inhibitors was acclaimed as a major breakthrough in cancer therapy. However, only a limited patient cohort shows sufficient response to therapy. Hence, there is a need for identifying new checkpoints and predictive...

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Bibliographic Details
Main Authors: Nathalie Babl, Joshua Hofbauer, Carina Matos, Florian Voll, Ayse Nur Menevse, Michael Rechenmacher, Ruth Mair, Philipp Beckhove, Wolfgang Herr, Peter J. Siska, Kathrin Renner, Marina Kreutz, Annette Schnell
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Oncology
Subjects:
cholesterol
LDL (low-density lipoprotein)
immunotherapy
PD-1
reactive oxygen species
CD154 (CD40L)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1107484/full

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