Real-time laser speckle contrast imaging for intraoperative neurovascular blood flow assessment: animal experimental study
Abstract The use of various blood flow control methods in neurovascular interventions is crucial for reducing postoperative complications. Neurosurgeons worldwide use different methods, such as contact Dopplerography, intraoperative indocyanine videoangiography (ICG) video angiography, fluorescein a...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-51022-2 |
| _version_ | 1797349997026476032 |
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| author | Anton Konovalov Fyodor Grebenev Dmitry Stavtsev Igor Kozlov Vadim Gadjiagaev Gennadii Piavchenko Dmitry Telyshev Alexander Yu. Gerasimenko Igor Meglinski Savely Zalogin Anton Artemyev Grigorii Golodnev Tatiana Shumeiko Shalva Eliava |
| author_facet | Anton Konovalov Fyodor Grebenev Dmitry Stavtsev Igor Kozlov Vadim Gadjiagaev Gennadii Piavchenko Dmitry Telyshev Alexander Yu. Gerasimenko Igor Meglinski Savely Zalogin Anton Artemyev Grigorii Golodnev Tatiana Shumeiko Shalva Eliava |
| author_sort | Anton Konovalov |
| collection | DOAJ |
| description | Abstract The use of various blood flow control methods in neurovascular interventions is crucial for reducing postoperative complications. Neurosurgeons worldwide use different methods, such as contact Dopplerography, intraoperative indocyanine videoangiography (ICG) video angiography, fluorescein angiography, flowmetry, intraoperative angiography, and direct angiography. However, there is no noninvasive method that can assess the presence of blood flow in the vessels of the brain without the introduction of fluorescent substances throughout the intervention. The real-time laser-speckle contrast imaging (LSCI) method was studied for its effectiveness in controlling blood flow in standard cerebrovascular surgery cases in rat common carotid arteries, such as proximal occlusion, trapping, reperfusion, anastomosis, and intraoperative vessel thrombosis. The real-time LSCI method is a promising method for use in neurosurgical practice. This approach allows timely diagnosis of intraoperative disturbance of blood flow in vessels in cases of clip occlusion or thrombosis. Additionally, LSCI allows us to reliably confirm the functioning of the anastomosis and reperfusion after removal of the clips and thrombolysis in real time. An unresolved limitation of the method is noise from movements, but this does not reduce the value of the method. Additional research is required to improve the quality of the data obtained. |
| first_indexed | 2024-03-08T12:38:25Z |
| format | Article |
| id | doaj.art-665e695b18fa40eead727298051cef96 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-08T12:38:25Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-665e695b18fa40eead727298051cef962024-01-21T12:18:48ZengNature PortfolioScientific Reports2045-23222024-01-0114111010.1038/s41598-023-51022-2Real-time laser speckle contrast imaging for intraoperative neurovascular blood flow assessment: animal experimental studyAnton Konovalov0Fyodor Grebenev1Dmitry Stavtsev2Igor Kozlov3Vadim Gadjiagaev4Gennadii Piavchenko5Dmitry Telyshev6Alexander Yu. Gerasimenko7Igor Meglinski8Savely Zalogin9Anton Artemyev10Grigorii Golodnev11Tatiana Shumeiko12Shalva Eliava13Burdenko Neurosurgшcal CenterBurdenko Neurosurgшcal CenterInstitute for Bionic Technologies and Engineering, I.M. Sechenov First Moscow State Medical UniversityInstitute for Bionic Technologies and Engineering, I.M. Sechenov First Moscow State Medical UniversityBurdenko Neurosurgшcal CenterDepartment of Human Anatomy and Histology, I.M. Sechenov First Moscow State Medical UniversityInstitute for Bionic Technologies and Engineering, I.M. Sechenov First Moscow State Medical UniversityInstitute for Bionic Technologies and Engineering, I.M. Sechenov First Moscow State Medical UniversityDepartment of Human Anatomy and Histology, I.M. Sechenov First Moscow State Medical UniversityDepartment of Operative Surgery and Topographic Anatomy, I.M, Sechenov First Moscow State Medical UniversityDepartment of Operative Surgery and Topographic Anatomy, I.M, Sechenov First Moscow State Medical UniversityDepartment of Operative Surgery and Topographic Anatomy, I.M, Sechenov First Moscow State Medical UniversityDepartment of Operative Surgery and Topographic Anatomy, I.M, Sechenov First Moscow State Medical UniversityBurdenko Neurosurgшcal CenterAbstract The use of various blood flow control methods in neurovascular interventions is crucial for reducing postoperative complications. Neurosurgeons worldwide use different methods, such as contact Dopplerography, intraoperative indocyanine videoangiography (ICG) video angiography, fluorescein angiography, flowmetry, intraoperative angiography, and direct angiography. However, there is no noninvasive method that can assess the presence of blood flow in the vessels of the brain without the introduction of fluorescent substances throughout the intervention. The real-time laser-speckle contrast imaging (LSCI) method was studied for its effectiveness in controlling blood flow in standard cerebrovascular surgery cases in rat common carotid arteries, such as proximal occlusion, trapping, reperfusion, anastomosis, and intraoperative vessel thrombosis. The real-time LSCI method is a promising method for use in neurosurgical practice. This approach allows timely diagnosis of intraoperative disturbance of blood flow in vessels in cases of clip occlusion or thrombosis. Additionally, LSCI allows us to reliably confirm the functioning of the anastomosis and reperfusion after removal of the clips and thrombolysis in real time. An unresolved limitation of the method is noise from movements, but this does not reduce the value of the method. Additional research is required to improve the quality of the data obtained.https://doi.org/10.1038/s41598-023-51022-2 |
| spellingShingle | Anton Konovalov Fyodor Grebenev Dmitry Stavtsev Igor Kozlov Vadim Gadjiagaev Gennadii Piavchenko Dmitry Telyshev Alexander Yu. Gerasimenko Igor Meglinski Savely Zalogin Anton Artemyev Grigorii Golodnev Tatiana Shumeiko Shalva Eliava Real-time laser speckle contrast imaging for intraoperative neurovascular blood flow assessment: animal experimental study Scientific Reports |
| title | Real-time laser speckle contrast imaging for intraoperative neurovascular blood flow assessment: animal experimental study |
| title_full | Real-time laser speckle contrast imaging for intraoperative neurovascular blood flow assessment: animal experimental study |
| title_fullStr | Real-time laser speckle contrast imaging for intraoperative neurovascular blood flow assessment: animal experimental study |
| title_full_unstemmed | Real-time laser speckle contrast imaging for intraoperative neurovascular blood flow assessment: animal experimental study |
| title_short | Real-time laser speckle contrast imaging for intraoperative neurovascular blood flow assessment: animal experimental study |
| title_sort | real time laser speckle contrast imaging for intraoperative neurovascular blood flow assessment animal experimental study |
| url | https://doi.org/10.1038/s41598-023-51022-2 |
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