Effects of Alcoholic Extracted and Dry Eggplant (Solanum Melongena) on Hyperlipidemia Treatment in Rats
This study was carried out to investigate the potential of crude ethanolic extracts of eggplant (Solanum melongena) peels, fruit, and seeds, as well as dry eggplant, in the treatment of hyperlipidemia in rats. Forty-nine adult female Sprague Dawley rats were used with a weighting between (280-340)...
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| Format: | Article |
| Language: | English |
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Faculty of Veterinary Medicine, University of Kufa
2023-06-01
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| Series: | Kufa Journal for Veterinary Medical Sciences |
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| Online Access: | https://journal.uokufa.edu.iq/index.php/kjvs/article/view/12070 |
| _version_ | 1797635046175145984 |
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| author | Hayder Hasan Khudiar Saadia Saleh Mehdy |
| author_facet | Hayder Hasan Khudiar Saadia Saleh Mehdy |
| author_sort | Hayder Hasan Khudiar |
| collection | DOAJ |
| description |
This study was carried out to investigate the potential of crude ethanolic extracts of eggplant (Solanum melongena) peels, fruit, and seeds, as well as dry eggplant, in the treatment of hyperlipidemia in rats. Forty-nine adult female Sprague Dawley rats were used with a weighting between (280-340) grams. Following the establishment of hyperlipidemia by providing them with a high-fat diet consisting of 4% cholesterol with 5% egg yolk for a period of 30 days in all groups except the control negative. Afterward, the rats were divided into seven groups of 7 rats as followed: The first group control negative was given standard pellets and water only, and the second group control positive induction hyperlipidemia this applied to all groups. Other groups (third, fourth, and five) were administered with alcoholic extracts of Solanum Melongena parts including the peel group, fruit group, and seed group, at a dose of 400 mg/kg/B.W. orally once a day, and group six received dry eggplant without extract at a dose of 200 mg/kg/diet once daily. The seven groups received atorvastatin at a dose of 20 mg/ B.W. orally once daily for a period of 45 days for all groups. The results of the study on serum lipid profile in rats indicated that the peel and atorvastatin groups exhibited a significant decrease in levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and low-density lipoprotein (VLDL). Furthermore, the peel and atorvastatin groups had substantially elevated high-density lipoprotein (HDL) levels. The study suggests that eggplant peel extract and atorvastatin, a common drug, can potentially treat hyperlipidemia in rats.
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| first_indexed | 2024-03-11T12:15:41Z |
| format | Article |
| id | doaj.art-665e69cccf6a467e8928f83cc9170ec0 |
| institution | Directory Open Access Journal |
| issn | 2077-9798 2959-8478 |
| language | English |
| last_indexed | 2024-03-11T12:15:41Z |
| publishDate | 2023-06-01 |
| publisher | Faculty of Veterinary Medicine, University of Kufa |
| record_format | Article |
| series | Kufa Journal for Veterinary Medical Sciences |
| spelling | doaj.art-665e69cccf6a467e8928f83cc9170ec02023-11-07T09:28:38ZengFaculty of Veterinary Medicine, University of KufaKufa Journal for Veterinary Medical Sciences2077-97982959-84782023-06-0114110.36326/kjvs/2023/v14i112070Effects of Alcoholic Extracted and Dry Eggplant (Solanum Melongena) on Hyperlipidemia Treatment in RatsHayder Hasan Khudiar0Saadia Saleh Mehdy1Department of Physiology, biochemistry, and Pharmacology Faculty of Vet. Medicine / University of KufaDepartment of Physiology, biochemistry, and Pharmacology Faculty of Vet. Medicine / University of Kufa This study was carried out to investigate the potential of crude ethanolic extracts of eggplant (Solanum melongena) peels, fruit, and seeds, as well as dry eggplant, in the treatment of hyperlipidemia in rats. Forty-nine adult female Sprague Dawley rats were used with a weighting between (280-340) grams. Following the establishment of hyperlipidemia by providing them with a high-fat diet consisting of 4% cholesterol with 5% egg yolk for a period of 30 days in all groups except the control negative. Afterward, the rats were divided into seven groups of 7 rats as followed: The first group control negative was given standard pellets and water only, and the second group control positive induction hyperlipidemia this applied to all groups. Other groups (third, fourth, and five) were administered with alcoholic extracts of Solanum Melongena parts including the peel group, fruit group, and seed group, at a dose of 400 mg/kg/B.W. orally once a day, and group six received dry eggplant without extract at a dose of 200 mg/kg/diet once daily. The seven groups received atorvastatin at a dose of 20 mg/ B.W. orally once daily for a period of 45 days for all groups. The results of the study on serum lipid profile in rats indicated that the peel and atorvastatin groups exhibited a significant decrease in levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and low-density lipoprotein (VLDL). Furthermore, the peel and atorvastatin groups had substantially elevated high-density lipoprotein (HDL) levels. The study suggests that eggplant peel extract and atorvastatin, a common drug, can potentially treat hyperlipidemia in rats. https://journal.uokufa.edu.iq/index.php/kjvs/article/view/12070HyperlipidemiaAtorvastatinHypercholesterolemiaEgg yolkExtract alcoholic eggplant and dry |
| spellingShingle | Hayder Hasan Khudiar Saadia Saleh Mehdy Effects of Alcoholic Extracted and Dry Eggplant (Solanum Melongena) on Hyperlipidemia Treatment in Rats Kufa Journal for Veterinary Medical Sciences Hyperlipidemia Atorvastatin Hypercholesterolemia Egg yolk Extract alcoholic eggplant and dry |
| title | Effects of Alcoholic Extracted and Dry Eggplant (Solanum Melongena) on Hyperlipidemia Treatment in Rats |
| title_full | Effects of Alcoholic Extracted and Dry Eggplant (Solanum Melongena) on Hyperlipidemia Treatment in Rats |
| title_fullStr | Effects of Alcoholic Extracted and Dry Eggplant (Solanum Melongena) on Hyperlipidemia Treatment in Rats |
| title_full_unstemmed | Effects of Alcoholic Extracted and Dry Eggplant (Solanum Melongena) on Hyperlipidemia Treatment in Rats |
| title_short | Effects of Alcoholic Extracted and Dry Eggplant (Solanum Melongena) on Hyperlipidemia Treatment in Rats |
| title_sort | effects of alcoholic extracted and dry eggplant solanum melongena on hyperlipidemia treatment in rats |
| topic | Hyperlipidemia Atorvastatin Hypercholesterolemia Egg yolk Extract alcoholic eggplant and dry |
| url | https://journal.uokufa.edu.iq/index.php/kjvs/article/view/12070 |
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