What’s the Matter with MICs: Bacterial Nutrition, Limiting Resources, and Antibiotic Pharmacodynamics

What’s the Matter with MICs: Bacterial Nutrition, Limiting Resources, and Antibiotic Pharmacodynamics

ABSTRACT The MIC of an antibiotic required to prevent replication is used both as a measure of the susceptibility/resistance of bacteria to that drug and as the single pharmacodynamic parameter for the rational design of antibiotic treatment regimes. MICs are experimentally estimated in vitro under...

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Bibliographic Details
Main Authors: Brandon A. Berryhill, Teresa Gil-Gil, Joshua A. Manuel, Andrew P. Smith, Ellie Margollis, Fernando Baquero, Bruce R. Levin
Format: Article
Language:English
Published: American Society for Microbiology 2023-06-01
Series:Microbiology Spectrum
Subjects:
antibiotics
minimum inhibitory concentration
pharmacodynamics
population biology
antibiotic resistance
heteroresistance
Online Access:https://journals.asm.org/doi/10.1128/spectrum.04091-22

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