Generation of a human induced pluripotent stem cell line from a patient diagnosed with schizophrenia carrying a 16p11.2 deletion
16p11.2 copy number variations have been associated with neurodevelopmental disorders. Human induced pluripotent stem cells were generated from fibroblasts obtained from a patient diagnosed with schizophrenia with a 16p11.2 deletion. The generated cell line was further validated for its pluripotency...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-03-01
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| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506121004839 |
| _version_ | 1798024668024668160 |
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| author | Deniz A. Madencioglu Karina Kruth Mallory Shin Nancy Andreasen Thomas Wassink Aislinn Williams |
| author_facet | Deniz A. Madencioglu Karina Kruth Mallory Shin Nancy Andreasen Thomas Wassink Aislinn Williams |
| author_sort | Deniz A. Madencioglu |
| collection | DOAJ |
| description | 16p11.2 copy number variations have been associated with neurodevelopmental disorders. Human induced pluripotent stem cells were generated from fibroblasts obtained from a patient diagnosed with schizophrenia with a 16p11.2 deletion. The generated cell line was further validated for its pluripotency and potential to differentiate into the three germ layers. |
| first_indexed | 2024-04-11T18:06:22Z |
| format | Article |
| id | doaj.art-6661ca983b524ac09066dccbe0336190 |
| institution | Directory Open Access Journal |
| issn | 1873-5061 |
| language | English |
| last_indexed | 2024-04-11T18:06:22Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj.art-6661ca983b524ac09066dccbe03361902022-12-22T04:10:19ZengElsevierStem Cell Research1873-50612022-03-0159102636Generation of a human induced pluripotent stem cell line from a patient diagnosed with schizophrenia carrying a 16p11.2 deletionDeniz A. Madencioglu0Karina Kruth1Mallory Shin2Nancy Andreasen3Thomas Wassink4Aislinn Williams5Department of Psychiatry, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USADepartment of Psychiatry, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USADepartment of Pathology, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USADepartment of Psychiatry, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USADepartment of Psychiatry, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USADepartment of Psychiatry, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA; Corresponding author.16p11.2 copy number variations have been associated with neurodevelopmental disorders. Human induced pluripotent stem cells were generated from fibroblasts obtained from a patient diagnosed with schizophrenia with a 16p11.2 deletion. The generated cell line was further validated for its pluripotency and potential to differentiate into the three germ layers.http://www.sciencedirect.com/science/article/pii/S1873506121004839 |
| spellingShingle | Deniz A. Madencioglu Karina Kruth Mallory Shin Nancy Andreasen Thomas Wassink Aislinn Williams Generation of a human induced pluripotent stem cell line from a patient diagnosed with schizophrenia carrying a 16p11.2 deletion Stem Cell Research |
| title | Generation of a human induced pluripotent stem cell line from a patient diagnosed with schizophrenia carrying a 16p11.2 deletion |
| title_full | Generation of a human induced pluripotent stem cell line from a patient diagnosed with schizophrenia carrying a 16p11.2 deletion |
| title_fullStr | Generation of a human induced pluripotent stem cell line from a patient diagnosed with schizophrenia carrying a 16p11.2 deletion |
| title_full_unstemmed | Generation of a human induced pluripotent stem cell line from a patient diagnosed with schizophrenia carrying a 16p11.2 deletion |
| title_short | Generation of a human induced pluripotent stem cell line from a patient diagnosed with schizophrenia carrying a 16p11.2 deletion |
| title_sort | generation of a human induced pluripotent stem cell line from a patient diagnosed with schizophrenia carrying a 16p11 2 deletion |
| url | http://www.sciencedirect.com/science/article/pii/S1873506121004839 |
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