Current concepts in the pathogenesis of periodontitis: from symbiosis to dysbiosis
ABSTRACTThe primary etiological agent for the initiation and progression of periodontal disease is the dental plaque biofilm which is an organized aggregation of microorganisms residing within a complex intercellular matrix. The non-specific plaque hypothesis was the first attempt to explain the rol...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Journal of Oral Microbiology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/20002297.2023.2197779 |
| _version_ | 1797449961490612224 |
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| author | Ali A. Abdulkareem Firas B. Al-Taweel Ali J.B. Al-Sharqi Sarhang S. Gul Aram Sha Iain L.C. Chapple |
| author_facet | Ali A. Abdulkareem Firas B. Al-Taweel Ali J.B. Al-Sharqi Sarhang S. Gul Aram Sha Iain L.C. Chapple |
| author_sort | Ali A. Abdulkareem |
| collection | DOAJ |
| description | ABSTRACTThe primary etiological agent for the initiation and progression of periodontal disease is the dental plaque biofilm which is an organized aggregation of microorganisms residing within a complex intercellular matrix. The non-specific plaque hypothesis was the first attempt to explain the role of the dental biofilm in the pathogenesis of periodontal diseases. However, the introduction of sophisticated diagnostic and laboratory assays has led to the realisation that the development of periodontitis requires more than a mere increase in the biomass of dental plaque. Indeed, multispecies biofilms exhibit complex interactions between the bacteria and the host. In addition, not all resident microorganisms within the biofilm are pathogenic, since beneficial bacteria exist that serve to maintain a symbiotic relationship between the plaque microbiome and the host’s immune-inflammatory response, preventing the emergence of pathogenic microorganisms and the development of dysbiosis. This review aims to highlight the development and structure of the dental plaque biofilm and to explore current literature on the transition from a healthy (symbiotic) to a diseased (dysbiotic) biofilm in periodontitis and the associated immune-inflammatory responses that drive periodontal tissue destruction and form mechanistic pathways that impact other systemic non-communicable diseases. |
| first_indexed | 2024-03-09T14:33:45Z |
| format | Article |
| id | doaj.art-6661f57cd550441c8a4ac6c644f670b5 |
| institution | Directory Open Access Journal |
| issn | 2000-2297 |
| language | English |
| last_indexed | 2024-03-09T14:33:45Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Oral Microbiology |
| spelling | doaj.art-6661f57cd550441c8a4ac6c644f670b52023-11-27T17:25:00ZengTaylor & Francis GroupJournal of Oral Microbiology2000-22972023-12-0115110.1080/20002297.2023.2197779Current concepts in the pathogenesis of periodontitis: from symbiosis to dysbiosisAli A. Abdulkareem0Firas B. Al-Taweel1Ali J.B. Al-Sharqi2Sarhang S. Gul3Aram Sha4Iain L.C. Chapple5Department of Periodontics, College of Dentistry, University of Baghdad, Baghdad, IraqDepartment of Periodontics, College of Dentistry, University of Baghdad, Baghdad, IraqDepartment of Periodontics, College of Dentistry, University of Baghdad, Baghdad, IraqCollege of Dentistry, University of Sulaimani, Sulaimani, IraqCollege of Dentistry, University of Sulaimani, Sulaimani, IraqPeriodontal Research Group, Institute of Clinical Sciences, College of Medical & Dental Sciences, University of Birmingham, Birmingham, UKABSTRACTThe primary etiological agent for the initiation and progression of periodontal disease is the dental plaque biofilm which is an organized aggregation of microorganisms residing within a complex intercellular matrix. The non-specific plaque hypothesis was the first attempt to explain the role of the dental biofilm in the pathogenesis of periodontal diseases. However, the introduction of sophisticated diagnostic and laboratory assays has led to the realisation that the development of periodontitis requires more than a mere increase in the biomass of dental plaque. Indeed, multispecies biofilms exhibit complex interactions between the bacteria and the host. In addition, not all resident microorganisms within the biofilm are pathogenic, since beneficial bacteria exist that serve to maintain a symbiotic relationship between the plaque microbiome and the host’s immune-inflammatory response, preventing the emergence of pathogenic microorganisms and the development of dysbiosis. This review aims to highlight the development and structure of the dental plaque biofilm and to explore current literature on the transition from a healthy (symbiotic) to a diseased (dysbiotic) biofilm in periodontitis and the associated immune-inflammatory responses that drive periodontal tissue destruction and form mechanistic pathways that impact other systemic non-communicable diseases.https://www.tandfonline.com/doi/10.1080/20002297.2023.2197779Dental biofilmsymbiosisdysbiosisinflammationperiodontal disease |
| spellingShingle | Ali A. Abdulkareem Firas B. Al-Taweel Ali J.B. Al-Sharqi Sarhang S. Gul Aram Sha Iain L.C. Chapple Current concepts in the pathogenesis of periodontitis: from symbiosis to dysbiosis Journal of Oral Microbiology Dental biofilm symbiosis dysbiosis inflammation periodontal disease |
| title | Current concepts in the pathogenesis of periodontitis: from symbiosis to dysbiosis |
| title_full | Current concepts in the pathogenesis of periodontitis: from symbiosis to dysbiosis |
| title_fullStr | Current concepts in the pathogenesis of periodontitis: from symbiosis to dysbiosis |
| title_full_unstemmed | Current concepts in the pathogenesis of periodontitis: from symbiosis to dysbiosis |
| title_short | Current concepts in the pathogenesis of periodontitis: from symbiosis to dysbiosis |
| title_sort | current concepts in the pathogenesis of periodontitis from symbiosis to dysbiosis |
| topic | Dental biofilm symbiosis dysbiosis inflammation periodontal disease |
| url | https://www.tandfonline.com/doi/10.1080/20002297.2023.2197779 |
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