Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma
Olfactory neuroblastoma (ONB) is a rare malignant tumor whose genetic basis is poorly understood. Here the authors identify recurrent deletions involving dystrophin in the majority of ONB patient tumors examined.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-07578-z |
| _version_ | 1818341799983316992 |
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| author | Gary L. Gallia Ming Zhang Yi Ning Michael C. Haffner Denise Batista Zev A. Binder Justin A. Bishop Christine L. Hann Ralph H. Hruban Masaru Ishii Alison P. Klein Douglas D. Reh Lisa M. Rooper Vafi Salmasi Rafael J. Tamargo Qing Wang Tara Williamson Tianna Zhao Ying Zou Alan K. Meeker Nishant Agrawal Bert Vogelstein Kenneth W. Kinzler Nickolas Papadopoulos Chetan Bettegowda |
| author_facet | Gary L. Gallia Ming Zhang Yi Ning Michael C. Haffner Denise Batista Zev A. Binder Justin A. Bishop Christine L. Hann Ralph H. Hruban Masaru Ishii Alison P. Klein Douglas D. Reh Lisa M. Rooper Vafi Salmasi Rafael J. Tamargo Qing Wang Tara Williamson Tianna Zhao Ying Zou Alan K. Meeker Nishant Agrawal Bert Vogelstein Kenneth W. Kinzler Nickolas Papadopoulos Chetan Bettegowda |
| author_sort | Gary L. Gallia |
| collection | DOAJ |
| description | Olfactory neuroblastoma (ONB) is a rare malignant tumor whose genetic basis is poorly understood. Here the authors identify recurrent deletions involving dystrophin in the majority of ONB patient tumors examined. |
| first_indexed | 2024-12-13T16:04:33Z |
| format | Article |
| id | doaj.art-666203899eb144b58109b82017f4bbe7 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:04:33Z |
| publishDate | 2018-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-666203899eb144b58109b82017f4bbe72022-12-21T23:39:04ZengNature PortfolioNature Communications2041-17232018-12-01911610.1038/s41467-018-07578-zGenomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastomaGary L. Gallia0Ming Zhang1Yi Ning2Michael C. Haffner3Denise Batista4Zev A. Binder5Justin A. Bishop6Christine L. Hann7Ralph H. Hruban8Masaru Ishii9Alison P. Klein10Douglas D. Reh11Lisa M. Rooper12Vafi Salmasi13Rafael J. Tamargo14Qing Wang15Tara Williamson16Tianna Zhao17Ying Zou18Alan K. Meeker19Nishant Agrawal20Bert Vogelstein21Kenneth W. Kinzler22Nickolas Papadopoulos23Chetan Bettegowda24Department of Neurosurgery, Johns Hopkins University School of MedicineLudwig Center for Cancer Genetics and Therapeutics, Department of Oncology and Pathology and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of MedicineDepartment of Pathology, Johns Hopkins University School of MedicineDepartment of Pathology, Johns Hopkins University School of MedicineDepartment of Pathology, Johns Hopkins University School of MedicineDepartment of Neurosurgery, Johns Hopkins University School of MedicineDepartment of Pathology, Johns Hopkins University School of MedicineDepartment of Oncology, Johns Hopkins University School of MedicineDepartment of Pathology, Johns Hopkins University School of MedicineDepartment of Neurosurgery, Johns Hopkins University School of MedicineDepartment of Oncology, Johns Hopkins University School of MedicineDepartment of Neurosurgery, Johns Hopkins University School of MedicineDepartment of Pathology, Johns Hopkins University School of MedicineDepartment of Neurosurgery, Johns Hopkins University School of MedicineDepartment of Neurosurgery, Johns Hopkins University School of MedicineLudwig Center for Cancer Genetics and Therapeutics, Department of Oncology and Pathology and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of MedicineDepartment of Neurosurgery, Johns Hopkins University School of MedicineDepartment of Neurosurgery, Johns Hopkins University School of MedicineDepartment of Pathology, University of Maryland School of MedicineDepartment of Pathology, Johns Hopkins University School of MedicineDepartment of Otolaryngology – Head and Neck Surgery, Johns Hopkins University School of MedicineLudwig Center for Cancer Genetics and Therapeutics, Department of Oncology and Pathology and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of MedicineLudwig Center for Cancer Genetics and Therapeutics, Department of Oncology and Pathology and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of MedicineLudwig Center for Cancer Genetics and Therapeutics, Department of Oncology and Pathology and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of MedicineDepartment of Neurosurgery, Johns Hopkins University School of MedicineOlfactory neuroblastoma (ONB) is a rare malignant tumor whose genetic basis is poorly understood. Here the authors identify recurrent deletions involving dystrophin in the majority of ONB patient tumors examined.https://doi.org/10.1038/s41467-018-07578-z |
| spellingShingle | Gary L. Gallia Ming Zhang Yi Ning Michael C. Haffner Denise Batista Zev A. Binder Justin A. Bishop Christine L. Hann Ralph H. Hruban Masaru Ishii Alison P. Klein Douglas D. Reh Lisa M. Rooper Vafi Salmasi Rafael J. Tamargo Qing Wang Tara Williamson Tianna Zhao Ying Zou Alan K. Meeker Nishant Agrawal Bert Vogelstein Kenneth W. Kinzler Nickolas Papadopoulos Chetan Bettegowda Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma Nature Communications |
| title | Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma |
| title_full | Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma |
| title_fullStr | Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma |
| title_full_unstemmed | Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma |
| title_short | Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma |
| title_sort | genomic analysis identifies frequent deletions of dystrophin in olfactory neuroblastoma |
| url | https://doi.org/10.1038/s41467-018-07578-z |
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