Clinical analysis of AN69ST membrane continuous venous hemofiltration in the treatment of severe sepsis
We aimed to investigate the clinical efficacy of blood purification technology based on cytokine adsorption in the treatment of sepsis. Sixty patients with sepsis were randomly divided into control (n = 30) and experimental (n = 30) groups. Both groups were given routine treatment and continuous ven...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2023-09-01
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| Series: | Open Medicine |
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| Online Access: | https://doi.org/10.1515/med-2023-0784 |
| _version_ | 1797682396314730496 |
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| author | Gao Yuqiang Huang Xiaohong Yang Yanan Lei Zhenlin Chen Qingan Guo Xu Tian Jia Gao Xiaoxin |
| author_facet | Gao Yuqiang Huang Xiaohong Yang Yanan Lei Zhenlin Chen Qingan Guo Xu Tian Jia Gao Xiaoxin |
| author_sort | Gao Yuqiang |
| collection | DOAJ |
| description | We aimed to investigate the clinical efficacy of blood purification technology based on cytokine adsorption in the treatment of sepsis. Sixty patients with sepsis were randomly divided into control (n = 30) and experimental (n = 30) groups. Both groups were given routine treatment and continuous venovenous hemofiltration, and on this basis, the experimental group received acrylonitrile/sodium methacrylate (AN69ST) blood purification. The levels of C-reactive protein, procalcitonin, white blood cell count, albumin, platelets, total bilirubin, creatinine, lactic acid, and APACE II score, as well as secretion of inflammatory factors interleukin (IL)-6 and tumor necrosis factor (TNF-α) were compared. The hospitalization time, mechanical ventilation (MV) time, drug use time, and mortality were analyzed. After treatment, the secretion levels of IL-6 and TNF-α were decreased, and other indicators were significantly improved compared with those before treatment (P < 0.05), especially in the experimental group (P < 0.05). The hospitalization time, MV time, and drug use time in the experimental group were significantly lower than those of the control group (P < 0.05), and the mortality was lower than that in the control group (P < 0.05). In conclusion, blood purification technology based on cytokine adsorption can significantly improve various indicators of sepsis patients, reduce hospitalization time, reduce mortality, and improve the prognosis. |
| first_indexed | 2024-03-11T23:59:09Z |
| format | Article |
| id | doaj.art-666493e5876e46b8839b5a756627ce73 |
| institution | Directory Open Access Journal |
| issn | 2391-5463 |
| language | English |
| last_indexed | 2024-03-11T23:59:09Z |
| publishDate | 2023-09-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj.art-666493e5876e46b8839b5a756627ce732023-09-18T06:31:54ZengDe GruyterOpen Medicine2391-54632023-09-01181758710.1515/med-2023-0784Clinical analysis of AN69ST membrane continuous venous hemofiltration in the treatment of severe sepsisGao Yuqiang0Huang Xiaohong1Yang Yanan2Lei Zhenlin3Chen Qingan4Guo Xu5Tian Jia6Gao Xiaoxin7Intensive Medical Unit, Hainan Medical University, 571199Haikou, ChinaIntensive Medical Unit, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, 570311, Haikou, ChinaIntensive Medical Unit, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, 570311, Haikou, ChinaIntensive Medical Unit, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, 570311, Haikou, ChinaIntensive Medical Unit, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, 570311, Haikou, ChinaIntensive Medical Unit, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, 570311, Haikou, ChinaIntensive Medical Unit, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, No. 19 Xiuhua Road, 570311Haikou, ChinaIntensive Medical Unit, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, No. 19 Xiuhua Road, 570311Haikou, ChinaWe aimed to investigate the clinical efficacy of blood purification technology based on cytokine adsorption in the treatment of sepsis. Sixty patients with sepsis were randomly divided into control (n = 30) and experimental (n = 30) groups. Both groups were given routine treatment and continuous venovenous hemofiltration, and on this basis, the experimental group received acrylonitrile/sodium methacrylate (AN69ST) blood purification. The levels of C-reactive protein, procalcitonin, white blood cell count, albumin, platelets, total bilirubin, creatinine, lactic acid, and APACE II score, as well as secretion of inflammatory factors interleukin (IL)-6 and tumor necrosis factor (TNF-α) were compared. The hospitalization time, mechanical ventilation (MV) time, drug use time, and mortality were analyzed. After treatment, the secretion levels of IL-6 and TNF-α were decreased, and other indicators were significantly improved compared with those before treatment (P < 0.05), especially in the experimental group (P < 0.05). The hospitalization time, MV time, and drug use time in the experimental group were significantly lower than those of the control group (P < 0.05), and the mortality was lower than that in the control group (P < 0.05). In conclusion, blood purification technology based on cytokine adsorption can significantly improve various indicators of sepsis patients, reduce hospitalization time, reduce mortality, and improve the prognosis.https://doi.org/10.1515/med-2023-0784sepsiscytokine adsorptionan69stblood purificationclinical efficacy |
| spellingShingle | Gao Yuqiang Huang Xiaohong Yang Yanan Lei Zhenlin Chen Qingan Guo Xu Tian Jia Gao Xiaoxin Clinical analysis of AN69ST membrane continuous venous hemofiltration in the treatment of severe sepsis Open Medicine sepsis cytokine adsorption an69st blood purification clinical efficacy |
| title | Clinical analysis of AN69ST membrane continuous venous hemofiltration in the treatment of severe sepsis |
| title_full | Clinical analysis of AN69ST membrane continuous venous hemofiltration in the treatment of severe sepsis |
| title_fullStr | Clinical analysis of AN69ST membrane continuous venous hemofiltration in the treatment of severe sepsis |
| title_full_unstemmed | Clinical analysis of AN69ST membrane continuous venous hemofiltration in the treatment of severe sepsis |
| title_short | Clinical analysis of AN69ST membrane continuous venous hemofiltration in the treatment of severe sepsis |
| title_sort | clinical analysis of an69st membrane continuous venous hemofiltration in the treatment of severe sepsis |
| topic | sepsis cytokine adsorption an69st blood purification clinical efficacy |
| url | https://doi.org/10.1515/med-2023-0784 |
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