Coronary Artery Disease is More Severe in Patients with Non-Alcoholic Steatohepatitis than Fatty Liver
Non-alcoholic fatty liver disease (NAFLD) is associated with a higher risk of atherosclerotic disease. However, the relationships between the severity of coronary atherosclerosis and pathologic findings in patients with NAFLD remain unknown. We aimed to characterize the coronary artery lesions in pa...
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| Format: | Article |
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MDPI AG
2020-02-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/10/3/129 |
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| author | Toshihiro Niikura Kento Imajo Anna Ozaki Takashi Kobayashi Michihiro Iwaki Yasushi Honda Takaomi Kessoku Yuji Ogawa Masato Yoneda Hiroyuki Kirikoshi Satoru Saito Atsushi Nakajima |
| author_facet | Toshihiro Niikura Kento Imajo Anna Ozaki Takashi Kobayashi Michihiro Iwaki Yasushi Honda Takaomi Kessoku Yuji Ogawa Masato Yoneda Hiroyuki Kirikoshi Satoru Saito Atsushi Nakajima |
| author_sort | Toshihiro Niikura |
| collection | DOAJ |
| description | Non-alcoholic fatty liver disease (NAFLD) is associated with a higher risk of atherosclerotic disease. However, the relationships between the severity of coronary atherosclerosis and pathologic findings in patients with NAFLD remain unknown. We aimed to characterize the coronary artery lesions in patients with NAFLD using coronary computed tomography angiography (CCTA). Overall, 101 patients with liver biopsy-proven NAFLD who had chest pain or electrocardiographic abnormalities underwent CCTA. Coronary artery lesions, including coronary artery stenosis (CAS), calcium score (CACS, Agatston score), and coronary artery non-calcified plaque were assessed using multi-slice CT. Multivariate analysis showed that age, smoking status, prevalence of dyslipidemia (DLP) and non-alcoholic steatohepatitis (NASH), and stage of fibrosis were independent risk factors for CAS. Age, and the prevalence of DM and DLP, were independent risk factors for CACS, and the prevalence of NASH tended to be an independent risk factor. In addition, the prevalence of DLP and NASH were independent risk factors for non-calcified plaques. Coronary artery lesions are more common in patients with NASH than in those with non-alcoholic fatty liver, suggesting a higher risk in patients with NASH. Therefore, patients with NASH should be closely followed, with particular vigilance for coronary artery diseases. |
| first_indexed | 2024-12-10T06:22:05Z |
| format | Article |
| id | doaj.art-6664b0e1cc9d400997a1dfc338dc7f78 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-12-10T06:22:05Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-6664b0e1cc9d400997a1dfc338dc7f782022-12-22T01:59:18ZengMDPI AGDiagnostics2075-44182020-02-0110312910.3390/diagnostics10030129diagnostics10030129Coronary Artery Disease is More Severe in Patients with Non-Alcoholic Steatohepatitis than Fatty LiverToshihiro Niikura0Kento Imajo1Anna Ozaki2Takashi Kobayashi3Michihiro Iwaki4Yasushi Honda5Takaomi Kessoku6Yuji Ogawa7Masato Yoneda8Hiroyuki Kirikoshi9Satoru Saito10Atsushi Nakajima11Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, JapanDepartment of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, JapanDepartment of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, JapanDepartment of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, JapanDepartment of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, JapanDepartment of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, JapanDepartment of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, JapanDepartment of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, JapanDepartment of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, JapanDepartment of Clinical Laboratory, Yokohama City University Hospital, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, JapanDepartment of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, JapanDepartment of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, JapanNon-alcoholic fatty liver disease (NAFLD) is associated with a higher risk of atherosclerotic disease. However, the relationships between the severity of coronary atherosclerosis and pathologic findings in patients with NAFLD remain unknown. We aimed to characterize the coronary artery lesions in patients with NAFLD using coronary computed tomography angiography (CCTA). Overall, 101 patients with liver biopsy-proven NAFLD who had chest pain or electrocardiographic abnormalities underwent CCTA. Coronary artery lesions, including coronary artery stenosis (CAS), calcium score (CACS, Agatston score), and coronary artery non-calcified plaque were assessed using multi-slice CT. Multivariate analysis showed that age, smoking status, prevalence of dyslipidemia (DLP) and non-alcoholic steatohepatitis (NASH), and stage of fibrosis were independent risk factors for CAS. Age, and the prevalence of DM and DLP, were independent risk factors for CACS, and the prevalence of NASH tended to be an independent risk factor. In addition, the prevalence of DLP and NASH were independent risk factors for non-calcified plaques. Coronary artery lesions are more common in patients with NASH than in those with non-alcoholic fatty liver, suggesting a higher risk in patients with NASH. Therefore, patients with NASH should be closely followed, with particular vigilance for coronary artery diseases.https://www.mdpi.com/2075-4418/10/3/129non-alcoholic fatty livernon-alcoholic steatohepatitiscoronary ct angiographycoronary artery lesionagatston score. |
| spellingShingle | Toshihiro Niikura Kento Imajo Anna Ozaki Takashi Kobayashi Michihiro Iwaki Yasushi Honda Takaomi Kessoku Yuji Ogawa Masato Yoneda Hiroyuki Kirikoshi Satoru Saito Atsushi Nakajima Coronary Artery Disease is More Severe in Patients with Non-Alcoholic Steatohepatitis than Fatty Liver Diagnostics non-alcoholic fatty liver non-alcoholic steatohepatitis coronary ct angiography coronary artery lesion agatston score. |
| title | Coronary Artery Disease is More Severe in Patients with Non-Alcoholic Steatohepatitis than Fatty Liver |
| title_full | Coronary Artery Disease is More Severe in Patients with Non-Alcoholic Steatohepatitis than Fatty Liver |
| title_fullStr | Coronary Artery Disease is More Severe in Patients with Non-Alcoholic Steatohepatitis than Fatty Liver |
| title_full_unstemmed | Coronary Artery Disease is More Severe in Patients with Non-Alcoholic Steatohepatitis than Fatty Liver |
| title_short | Coronary Artery Disease is More Severe in Patients with Non-Alcoholic Steatohepatitis than Fatty Liver |
| title_sort | coronary artery disease is more severe in patients with non alcoholic steatohepatitis than fatty liver |
| topic | non-alcoholic fatty liver non-alcoholic steatohepatitis coronary ct angiography coronary artery lesion agatston score. |
| url | https://www.mdpi.com/2075-4418/10/3/129 |
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