COX-2 Expression in Carcinoma of the Breast and Surrounding Non-neoplastic Breast Tissue
Background: Breast carcinoma is the most common malignant tumor and leading cause of cancer related death in women worldwide. Apart from traditional markers, estrogen receptor, progesterone receptor and Her-2neu, which are important for prognostication and staging purposes, a novel marker cyclooxyge...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Kaviani Breast Disease Institute
2021-01-01
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| Series: | Archives of Breast Cancer |
| Subjects: | |
| Online Access: | https://www.archbreastcancer.com/index.php/abc/article/view/342 |
| _version_ | 1798014272890994688 |
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| author | Namita Bhutani Shilpi Moga Pooja Poswal Bhanu Sharma Sunil Arora Sham Singla |
| author_facet | Namita Bhutani Shilpi Moga Pooja Poswal Bhanu Sharma Sunil Arora Sham Singla |
| author_sort | Namita Bhutani |
| collection | DOAJ |
| description | Background: Breast carcinoma is the most common malignant tumor and leading cause of cancer related death in women worldwide. Apart from traditional markers, estrogen receptor, progesterone receptor and Her-2neu, which are important for prognostication and staging purposes, a novel marker cyclooxygenase-2 (COX-2) is being studied extensively. We intend to study the spectrum of COX-2 expression in normal breast tissue, ductal carcinoma in situ (DCIS) adjacent to invasive cancer, and in invasive cancer and compare COX-2 expression with histological prognostic parameters and hormone receptor status.
Methods: The present study is a prospective study that was conducted in the department of Pathology, SGT Medical College and Hospital, Gurugram (2019-2020). Fifty patients, aged between 21 and 70, suffering from primary breast cancer constituted the study group. Various histological prognostic parameters were assessed. Immunohistochemical profile of the tumor was assessed. COX-2 score was correlated with various clinicopathologic parameters.
Results: Among the total of 50 patients suffering from invasive breast carcinoma, 94 percent (47/50) of cases showed the same COX-2 expression level in normal breast epithelium and corresponding tumor areas and this correlation was statistically significant. The correlation between the level of COX-2 expression in tumor and DCIS was highly significant.
Conclusion: Inhibition of COX-2 may represent a potential target for preventing breast cancer oncogenesis and as an adjuvant treatment following surgery to reduce local recurrence. |
| first_indexed | 2024-04-11T15:14:53Z |
| format | Article |
| id | doaj.art-6665ad9cf3514666aeb27a0fafab72a2 |
| institution | Directory Open Access Journal |
| issn | 2383-0433 |
| language | English |
| last_indexed | 2024-04-11T15:14:53Z |
| publishDate | 2021-01-01 |
| publisher | Kaviani Breast Disease Institute |
| record_format | Article |
| series | Archives of Breast Cancer |
| spelling | doaj.art-6665ad9cf3514666aeb27a0fafab72a22022-12-22T04:16:30ZengKaviani Breast Disease InstituteArchives of Breast Cancer2383-04332021-01-0110.32768/abc.20218129-36COX-2 Expression in Carcinoma of the Breast and Surrounding Non-neoplastic Breast TissueNamita Bhutani0Shilpi Moga1Pooja Poswal2Bhanu Sharma3Sunil Arora4Sham Singla5North DMC Medical College and Hindu Rao Hospital, Delhi, IndiaDepartment of Pathology, SGT Medical College & University Gurugram, Haryana, IndiaDepartment of Pathology, SGT Medical College & University Gurugram, Haryana, IndiaDepartment of Pathology, SGT Medical College & University Gurugram, Haryana, IndiaDepartment of Pathology, SGT Medical College & University Gurugram, Haryana, IndiaDepartment of Surgery, SGT Medical College & University Gurugram, Haryana, IndiaBackground: Breast carcinoma is the most common malignant tumor and leading cause of cancer related death in women worldwide. Apart from traditional markers, estrogen receptor, progesterone receptor and Her-2neu, which are important for prognostication and staging purposes, a novel marker cyclooxygenase-2 (COX-2) is being studied extensively. We intend to study the spectrum of COX-2 expression in normal breast tissue, ductal carcinoma in situ (DCIS) adjacent to invasive cancer, and in invasive cancer and compare COX-2 expression with histological prognostic parameters and hormone receptor status. Methods: The present study is a prospective study that was conducted in the department of Pathology, SGT Medical College and Hospital, Gurugram (2019-2020). Fifty patients, aged between 21 and 70, suffering from primary breast cancer constituted the study group. Various histological prognostic parameters were assessed. Immunohistochemical profile of the tumor was assessed. COX-2 score was correlated with various clinicopathologic parameters. Results: Among the total of 50 patients suffering from invasive breast carcinoma, 94 percent (47/50) of cases showed the same COX-2 expression level in normal breast epithelium and corresponding tumor areas and this correlation was statistically significant. The correlation between the level of COX-2 expression in tumor and DCIS was highly significant. Conclusion: Inhibition of COX-2 may represent a potential target for preventing breast cancer oncogenesis and as an adjuvant treatment following surgery to reduce local recurrence.https://www.archbreastcancer.com/index.php/abc/article/view/342Autocrine effect; Breast Cancer; Carcinogenesis; COX-2 expression; Paracrine effect. |
| spellingShingle | Namita Bhutani Shilpi Moga Pooja Poswal Bhanu Sharma Sunil Arora Sham Singla COX-2 Expression in Carcinoma of the Breast and Surrounding Non-neoplastic Breast Tissue Archives of Breast Cancer Autocrine effect; Breast Cancer; Carcinogenesis; COX-2 expression; Paracrine effect. |
| title | COX-2 Expression in Carcinoma of the Breast and Surrounding Non-neoplastic Breast Tissue |
| title_full | COX-2 Expression in Carcinoma of the Breast and Surrounding Non-neoplastic Breast Tissue |
| title_fullStr | COX-2 Expression in Carcinoma of the Breast and Surrounding Non-neoplastic Breast Tissue |
| title_full_unstemmed | COX-2 Expression in Carcinoma of the Breast and Surrounding Non-neoplastic Breast Tissue |
| title_short | COX-2 Expression in Carcinoma of the Breast and Surrounding Non-neoplastic Breast Tissue |
| title_sort | cox 2 expression in carcinoma of the breast and surrounding non neoplastic breast tissue |
| topic | Autocrine effect; Breast Cancer; Carcinogenesis; COX-2 expression; Paracrine effect. |
| url | https://www.archbreastcancer.com/index.php/abc/article/view/342 |
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