HIF-1α drives resistance to ferroptosis in solid tumors by promoting lactate production and activating SLC1A1

HIF-1α drives resistance to ferroptosis in solid tumors by promoting lactate production and activating SLC1A1

Summary: Solid tumors have developed robust ferroptosis resistance. The mechanism underlying ferroptosis resistance regulation in solid tumors, however, remains elusive. Here, we report that the hypoxic tumor microenvironment potently promotes ferroptosis resistance in solid tumors in a hypoxia-indu...

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Bibliographic Details
Main Authors: Zhou Yang, Wei Su, Xiyi Wei, Shuang Qu, Dan Zhao, Jingwan Zhou, Yunjun Wang, Qing Guan, Chao Qin, Jun Xiang, Ke Zen, Bing Yao
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Cell Reports
Subjects:
CP: Cancer
CP: Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723009567

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