The UDPase ENTPD5 regulates ER stress-associated renal injury by mediating protein N-glycosylation

The UDPase ENTPD5 regulates ER stress-associated renal injury by mediating protein N-glycosylation

Abstract Impaired protein N-glycosylation leads to the endoplasmic reticulum (ER) stress, which triggers adaptive survival or maladaptive apoptosis in renal tubules in diabetic kidney disease (DKD). Therapeutic strategies targeting ER stress are promising for the treatment of DKD. Here, we report a...

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Bibliographic Details
Main Authors: Lifen Xu, Yuxia Zhou, Guifang Wang, Li Bo, Bangming Jin, Lujun Dai, Qinli Lu, Xueni Cai, Laying Hu, Lu Liu, Yixuan Wu, Xuebing Chang, Yali Huang, Lingyu Song, Tian Zhang, Yuanyuan Wang, Ying Xiao, Fan Zhang, Lingling Liu, Mingjun Shi, Tuanlao Wang, Bing Guo
Format: Article
Language:English
Published: Nature Publishing Group 2023-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-05685-4

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