Epidemiology and microbiology of fracture-related infection: a multicenter study in Northeast China
Abstract Objective This study aimed to explore the epidemiological and microbiological characteristics of fracture-related infection (FRI), analyze the drug resistance characteristics of major pathogens, and provide timely and relatively complete clinical and microbiological data for antimicrobial t...
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| Format: | Article |
| Language: | English |
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BMC
2021-08-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13018-021-02629-6 |
| _version_ | 1811182864184639488 |
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| author | Baisheng Wang Xiaoguang Xiao Jingdong Zhang Wenfeng Han Salad Abdirahman Hersi Xin Tang |
| author_facet | Baisheng Wang Xiaoguang Xiao Jingdong Zhang Wenfeng Han Salad Abdirahman Hersi Xin Tang |
| author_sort | Baisheng Wang |
| collection | DOAJ |
| description | Abstract Objective This study aimed to explore the epidemiological and microbiological characteristics of fracture-related infection (FRI), analyze the drug resistance characteristics of major pathogens, and provide timely and relatively complete clinical and microbiological data for antimicrobial treatment of FRI. Methods The clinical and microbiological data of patients with FRI from January 1, 2011, to December 31, 2020, were collected from three tertiary hospitals in Northeast China. The automatic microbial analysis system was used for strain identification and drug susceptibility testing, and the drug susceptibility results were determined in accordance with the latest Clinical and Laboratory Standards Institute (CLSI) criteria (as applicable each year). Results A total of 744 patients with FRI were enrolled. The incidence of FRI was about 1.5%, and 81.7% were male patients, with an average age of 48.98 ± 16.01 years. Open fractures accounted for 64.8%. Motor crush (32.8%) and falling (29.8%) were the main causes of injuries. The common sites of infection were the tibia and fibula (47.6%), femur (11.8%), foot (11.8%), and hand (11.6%). A total of 566 pathogenic bacteria were cultured in 378 patients with positive bacterial cultures, of which 53.0% were Gram-positive bacteria and 47.0% were Gram-negative bacteria. The most common pathogen at all sites of infection is Staphylococcus aureus. Staphylococcus aureus had a high resistance rate to penicillin (PEN), erythromycin (ERY), and clindamycin (CLI), exceeding 50%. Methicillin-resistant Staphylococcus aureus (MRSA) was more than 80% resistant to CLI and ERY. Conclusions The incidence of FRI in Northeast China was at a low level among major medical centers nationwide. Staphylococcus aureus was still the main pathogen causing bone infections, and the proportion of MRSA was lower than reported abroad, but we have observed an increase in the proportion of infections. Enterobacteriaceae have a higher resistance rate to third-generation cephalosporins and quinolones. For Enterobacteriaceae, other sensitive treatment drugs should be selected clinically. |
| first_indexed | 2024-04-11T09:38:47Z |
| format | Article |
| id | doaj.art-6669b04bd19545a9928d38c0ae37d4e9 |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-11T09:38:47Z |
| publishDate | 2021-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-6669b04bd19545a9928d38c0ae37d4e92022-12-22T04:31:27ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2021-08-0116111110.1186/s13018-021-02629-6Epidemiology and microbiology of fracture-related infection: a multicenter study in Northeast ChinaBaisheng Wang0Xiaoguang Xiao1Jingdong Zhang2Wenfeng Han3Salad Abdirahman Hersi4Xin Tang5Department of Orthopedics, First Affiliated Hospital of Dalian Medical UniversityDepartment of Clinical Laboratory, First Affiliated Hospital of Dalian Medical UniversityDepartment of Orthopedics, Northeast International HospitalDepartment of Orthopedics, The General Hospital of Northern Theater CommandDepartment of Orthopedics, First Affiliated Hospital of Dalian Medical UniversityDepartment of Orthopedics, First Affiliated Hospital of Dalian Medical UniversityAbstract Objective This study aimed to explore the epidemiological and microbiological characteristics of fracture-related infection (FRI), analyze the drug resistance characteristics of major pathogens, and provide timely and relatively complete clinical and microbiological data for antimicrobial treatment of FRI. Methods The clinical and microbiological data of patients with FRI from January 1, 2011, to December 31, 2020, were collected from three tertiary hospitals in Northeast China. The automatic microbial analysis system was used for strain identification and drug susceptibility testing, and the drug susceptibility results were determined in accordance with the latest Clinical and Laboratory Standards Institute (CLSI) criteria (as applicable each year). Results A total of 744 patients with FRI were enrolled. The incidence of FRI was about 1.5%, and 81.7% were male patients, with an average age of 48.98 ± 16.01 years. Open fractures accounted for 64.8%. Motor crush (32.8%) and falling (29.8%) were the main causes of injuries. The common sites of infection were the tibia and fibula (47.6%), femur (11.8%), foot (11.8%), and hand (11.6%). A total of 566 pathogenic bacteria were cultured in 378 patients with positive bacterial cultures, of which 53.0% were Gram-positive bacteria and 47.0% were Gram-negative bacteria. The most common pathogen at all sites of infection is Staphylococcus aureus. Staphylococcus aureus had a high resistance rate to penicillin (PEN), erythromycin (ERY), and clindamycin (CLI), exceeding 50%. Methicillin-resistant Staphylococcus aureus (MRSA) was more than 80% resistant to CLI and ERY. Conclusions The incidence of FRI in Northeast China was at a low level among major medical centers nationwide. Staphylococcus aureus was still the main pathogen causing bone infections, and the proportion of MRSA was lower than reported abroad, but we have observed an increase in the proportion of infections. Enterobacteriaceae have a higher resistance rate to third-generation cephalosporins and quinolones. For Enterobacteriaceae, other sensitive treatment drugs should be selected clinically.https://doi.org/10.1186/s13018-021-02629-6EpidemiologyMicrobiologyFracture-related infectionBacterial resistance |
| spellingShingle | Baisheng Wang Xiaoguang Xiao Jingdong Zhang Wenfeng Han Salad Abdirahman Hersi Xin Tang Epidemiology and microbiology of fracture-related infection: a multicenter study in Northeast China Journal of Orthopaedic Surgery and Research Epidemiology Microbiology Fracture-related infection Bacterial resistance |
| title | Epidemiology and microbiology of fracture-related infection: a multicenter study in Northeast China |
| title_full | Epidemiology and microbiology of fracture-related infection: a multicenter study in Northeast China |
| title_fullStr | Epidemiology and microbiology of fracture-related infection: a multicenter study in Northeast China |
| title_full_unstemmed | Epidemiology and microbiology of fracture-related infection: a multicenter study in Northeast China |
| title_short | Epidemiology and microbiology of fracture-related infection: a multicenter study in Northeast China |
| title_sort | epidemiology and microbiology of fracture related infection a multicenter study in northeast china |
| topic | Epidemiology Microbiology Fracture-related infection Bacterial resistance |
| url | https://doi.org/10.1186/s13018-021-02629-6 |
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