<i>p53</i> Deficiency-Dependent Oncogenicity of Runx3
The RUNX transcription factors are frequently dysregulated in human cancers, suggesting their potential as attractive targets for drug treatment. However, all three transcription factors have been described as both tumor suppressors and oncogenes, indicating the need to determine their molecular mec...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/8/1122 |
| _version_ | 1827745510927106048 |
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| author | Kosei Ito Shohei Otani Yuki Date |
| author_facet | Kosei Ito Shohei Otani Yuki Date |
| author_sort | Kosei Ito |
| collection | DOAJ |
| description | The RUNX transcription factors are frequently dysregulated in human cancers, suggesting their potential as attractive targets for drug treatment. However, all three transcription factors have been described as both tumor suppressors and oncogenes, indicating the need to determine their molecular mechanisms of action. Although RUNX3 has long been considered a tumor suppressor in human cancers, several recent studies have shown that RUNX3 is upregulated during the development or progression of various malignant tumors, suggesting it may act as a “conditional” oncogene. Resolving this paradox and understanding how a single gene can exhibit both oncogenic and tumor-suppressive properties is essential for successful drug targeting of RUNX. This review describes the evidence for the activities of RUNX3 in human cancer and proposes an explanation for the duality of RUNX3 involving the status of p53. In this model, <i>p53</i> deficiency causes RUNX3 to become oncogenic, leading to aberrant upregulation of MYC. |
| first_indexed | 2024-03-11T05:09:04Z |
| format | Article |
| id | doaj.art-666c35d5949a4bd6bee3df22f926229d |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T05:09:04Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-666c35d5949a4bd6bee3df22f926229d2023-11-17T18:42:50ZengMDPI AGCells2073-44092023-04-01128112210.3390/cells12081122<i>p53</i> Deficiency-Dependent Oncogenicity of Runx3Kosei Ito0Shohei Otani1Yuki Date2Department of Molecular Bone Biology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8588, JapanDepartment of Molecular Bone Biology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8588, JapanDepartment of Molecular Bone Biology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8588, JapanThe RUNX transcription factors are frequently dysregulated in human cancers, suggesting their potential as attractive targets for drug treatment. However, all three transcription factors have been described as both tumor suppressors and oncogenes, indicating the need to determine their molecular mechanisms of action. Although RUNX3 has long been considered a tumor suppressor in human cancers, several recent studies have shown that RUNX3 is upregulated during the development or progression of various malignant tumors, suggesting it may act as a “conditional” oncogene. Resolving this paradox and understanding how a single gene can exhibit both oncogenic and tumor-suppressive properties is essential for successful drug targeting of RUNX. This review describes the evidence for the activities of RUNX3 in human cancer and proposes an explanation for the duality of RUNX3 involving the status of p53. In this model, <i>p53</i> deficiency causes RUNX3 to become oncogenic, leading to aberrant upregulation of MYC.https://www.mdpi.com/2073-4409/12/8/1122Runx3p53c-MycosteosarcomaT-cell lymphoma |
| spellingShingle | Kosei Ito Shohei Otani Yuki Date <i>p53</i> Deficiency-Dependent Oncogenicity of Runx3 Cells Runx3 p53 c-Myc osteosarcoma T-cell lymphoma |
| title | <i>p53</i> Deficiency-Dependent Oncogenicity of Runx3 |
| title_full | <i>p53</i> Deficiency-Dependent Oncogenicity of Runx3 |
| title_fullStr | <i>p53</i> Deficiency-Dependent Oncogenicity of Runx3 |
| title_full_unstemmed | <i>p53</i> Deficiency-Dependent Oncogenicity of Runx3 |
| title_short | <i>p53</i> Deficiency-Dependent Oncogenicity of Runx3 |
| title_sort | i p53 i deficiency dependent oncogenicity of runx3 |
| topic | Runx3 p53 c-Myc osteosarcoma T-cell lymphoma |
| url | https://www.mdpi.com/2073-4409/12/8/1122 |
| work_keys_str_mv | AT koseiito ip53ideficiencydependentoncogenicityofrunx3 AT shoheiotani ip53ideficiencydependentoncogenicityofrunx3 AT yukidate ip53ideficiencydependentoncogenicityofrunx3 |