Anti-leishmanial activity of alkaloidal extract from Aspidosperma ramiflorum
Infections due to protozoa of the genus Leishmania are a major worldwide health problem, with high endemicity in developing countries. The drugs of choice for the treatment of leishmaniasis are the pentavalent antimonials (SbV), which present renal and cardiac toxicity. Besides, the precise chemical...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2004-05-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000300015 |
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| author | Izabel Cristina Piloto Ferreira Maria Valdrinez Campana Lonardoni Gerzia MC Machado Leonor L Leon Lucílio Gobbi Filho Luís Henrique Bissoli Pinto Arildo José Braz de Oliveira |
| author_facet | Izabel Cristina Piloto Ferreira Maria Valdrinez Campana Lonardoni Gerzia MC Machado Leonor L Leon Lucílio Gobbi Filho Luís Henrique Bissoli Pinto Arildo José Braz de Oliveira |
| author_sort | Izabel Cristina Piloto Ferreira |
| collection | DOAJ |
| description | Infections due to protozoa of the genus Leishmania are a major worldwide health problem, with high endemicity in developing countries. The drugs of choice for the treatment of leishmaniasis are the pentavalent antimonials (SbV), which present renal and cardiac toxicity. Besides, the precise chemical structure and mechanism of action of these drugs are unknown up to date. In order to find new drugs against leishmaniasis, we have been studying extracts of Brazilian trees. In the present study, we have evaluated the effectiveness of an alkaloid extract of Aspidosperma ramiflorum Muell. Arg. (Apocynaceae), against the extracellular forms promastigotes of L. (L.) amazonensis and L. (V.) braziliensis. The alkaloid extract of A. ramiflorum was much more effective against L. (L.) amazonensis (LD50 < 47 µg/ml) than L. (V.) braziliensis. Based on these in vitro results against L. (L.) amazonensis new studies should be made to find the compounds with anti-leishmanial activity. |
| first_indexed | 2024-03-12T18:03:29Z |
| format | Article |
| id | doaj.art-666cdda97e7e4c0a91653fe8f66ff35e |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:03:29Z |
| publishDate | 2004-05-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-666cdda97e7e4c0a91653fe8f66ff35e2023-08-02T09:32:22ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602004-05-0199332532710.1590/S0074-02762004000300015Anti-leishmanial activity of alkaloidal extract from Aspidosperma ramiflorumIzabel Cristina Piloto FerreiraMaria Valdrinez Campana LonardoniGerzia MC MachadoLeonor L LeonLucílio Gobbi FilhoLuís Henrique Bissoli PintoArildo José Braz de OliveiraInfections due to protozoa of the genus Leishmania are a major worldwide health problem, with high endemicity in developing countries. The drugs of choice for the treatment of leishmaniasis are the pentavalent antimonials (SbV), which present renal and cardiac toxicity. Besides, the precise chemical structure and mechanism of action of these drugs are unknown up to date. In order to find new drugs against leishmaniasis, we have been studying extracts of Brazilian trees. In the present study, we have evaluated the effectiveness of an alkaloid extract of Aspidosperma ramiflorum Muell. Arg. (Apocynaceae), against the extracellular forms promastigotes of L. (L.) amazonensis and L. (V.) braziliensis. The alkaloid extract of A. ramiflorum was much more effective against L. (L.) amazonensis (LD50 < 47 µg/ml) than L. (V.) braziliensis. Based on these in vitro results against L. (L.) amazonensis new studies should be made to find the compounds with anti-leishmanial activity.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000300015Apocynaceaeanti-leishmanial activityBrazilian trees- monoterpenoid indolic alkaloidsAspidosperma ramiflorumLeishmania amazonensis- Leishmania braziliensis |
| spellingShingle | Izabel Cristina Piloto Ferreira Maria Valdrinez Campana Lonardoni Gerzia MC Machado Leonor L Leon Lucílio Gobbi Filho Luís Henrique Bissoli Pinto Arildo José Braz de Oliveira Anti-leishmanial activity of alkaloidal extract from Aspidosperma ramiflorum Memorias do Instituto Oswaldo Cruz Apocynaceae anti-leishmanial activity Brazilian trees - monoterpenoid indolic alkaloids Aspidosperma ramiflorum Leishmania amazonensis - Leishmania braziliensis |
| title | Anti-leishmanial activity of alkaloidal extract from Aspidosperma ramiflorum |
| title_full | Anti-leishmanial activity of alkaloidal extract from Aspidosperma ramiflorum |
| title_fullStr | Anti-leishmanial activity of alkaloidal extract from Aspidosperma ramiflorum |
| title_full_unstemmed | Anti-leishmanial activity of alkaloidal extract from Aspidosperma ramiflorum |
| title_short | Anti-leishmanial activity of alkaloidal extract from Aspidosperma ramiflorum |
| title_sort | anti leishmanial activity of alkaloidal extract from aspidosperma ramiflorum |
| topic | Apocynaceae anti-leishmanial activity Brazilian trees - monoterpenoid indolic alkaloids Aspidosperma ramiflorum Leishmania amazonensis - Leishmania braziliensis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000300015 |
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