Nanotechnology-based strategies for effective delivery of phytoconstituents for the management of rheumatoid arthritis
Rheumatoid arthritis [RA] is a painful disorder that causes inflammation in synovial membrane followed by damage to cartilage and bone. Several therapies are available for its management that include anti-inflammatory and disease- modifying antirheumatic drugs. Due to the severe side effects associa...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-03-01
|
| Series: | Pharmacological Research - Modern Chinese Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667142522000227 |
| _version_ | 1818320128553517056 |
|---|---|
| author | Monika Joshi Kamla Pathak Suneela Dhaneshwar |
| author_facet | Monika Joshi Kamla Pathak Suneela Dhaneshwar |
| author_sort | Monika Joshi |
| collection | DOAJ |
| description | Rheumatoid arthritis [RA] is a painful disorder that causes inflammation in synovial membrane followed by damage to cartilage and bone. Several therapies are available for its management that include anti-inflammatory and disease- modifying antirheumatic drugs. Due to the severe side effects associated with them, phytotherapy may serve as a promising and beneficial approach for management of rheumatoid arthritis and the therapeutic potential can be attributed to their ability to target various inflammatory mediators including nitric oxide [NO], cytokines, chemokines, adhesion molecules, nuclear factor kappa-b [NF-kb], lipoxygenase [LOXs] and arachidonic acid [AA]. Further, nanomedicine could serve as a prominent formulation strategy to overcome the challenges associated with phytoconstituents like poor bioavailability, high first pass metabolism and lower stability. Present review focuses on providing an exhaustive account of various phytoconstituents that have significant potential in RA management, their drawbacks, reported novel drug formulations, regulatory aspects involved therein. |
| first_indexed | 2024-12-13T10:20:05Z |
| format | Article |
| id | doaj.art-666d73730bf94d07bc4717c3db33baff |
| institution | Directory Open Access Journal |
| issn | 2667-1425 |
| language | English |
| last_indexed | 2024-12-13T10:20:05Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research - Modern Chinese Medicine |
| spelling | doaj.art-666d73730bf94d07bc4717c3db33baff2022-12-21T23:51:12ZengElsevierPharmacological Research - Modern Chinese Medicine2667-14252022-03-012100061Nanotechnology-based strategies for effective delivery of phytoconstituents for the management of rheumatoid arthritisMonika Joshi0Kamla Pathak1Suneela Dhaneshwar2Samarpan College of Pharmacy, Chinhut Deva Road, Lucknow-226028, U.P., IndiaPharmacy College Saifai, Uttar Pradesh University of Medical Sciences, Saifai, Etawah- 206130, U.P., India.; Corresponding author.Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus, Near Malhaur Rly station, P. O. Chinhat, Lucknow-226028, U.P., India.Rheumatoid arthritis [RA] is a painful disorder that causes inflammation in synovial membrane followed by damage to cartilage and bone. Several therapies are available for its management that include anti-inflammatory and disease- modifying antirheumatic drugs. Due to the severe side effects associated with them, phytotherapy may serve as a promising and beneficial approach for management of rheumatoid arthritis and the therapeutic potential can be attributed to their ability to target various inflammatory mediators including nitric oxide [NO], cytokines, chemokines, adhesion molecules, nuclear factor kappa-b [NF-kb], lipoxygenase [LOXs] and arachidonic acid [AA]. Further, nanomedicine could serve as a prominent formulation strategy to overcome the challenges associated with phytoconstituents like poor bioavailability, high first pass metabolism and lower stability. Present review focuses on providing an exhaustive account of various phytoconstituents that have significant potential in RA management, their drawbacks, reported novel drug formulations, regulatory aspects involved therein.http://www.sciencedirect.com/science/article/pii/S2667142522000227AutoimmuneInflammationPhytoconstituentNovel drug delivery systemNanotechnology |
| spellingShingle | Monika Joshi Kamla Pathak Suneela Dhaneshwar Nanotechnology-based strategies for effective delivery of phytoconstituents for the management of rheumatoid arthritis Pharmacological Research - Modern Chinese Medicine Autoimmune Inflammation Phytoconstituent Novel drug delivery system Nanotechnology |
| title | Nanotechnology-based strategies for effective delivery of phytoconstituents for the management of rheumatoid arthritis |
| title_full | Nanotechnology-based strategies for effective delivery of phytoconstituents for the management of rheumatoid arthritis |
| title_fullStr | Nanotechnology-based strategies for effective delivery of phytoconstituents for the management of rheumatoid arthritis |
| title_full_unstemmed | Nanotechnology-based strategies for effective delivery of phytoconstituents for the management of rheumatoid arthritis |
| title_short | Nanotechnology-based strategies for effective delivery of phytoconstituents for the management of rheumatoid arthritis |
| title_sort | nanotechnology based strategies for effective delivery of phytoconstituents for the management of rheumatoid arthritis |
| topic | Autoimmune Inflammation Phytoconstituent Novel drug delivery system Nanotechnology |
| url | http://www.sciencedirect.com/science/article/pii/S2667142522000227 |
| work_keys_str_mv | AT monikajoshi nanotechnologybasedstrategiesforeffectivedeliveryofphytoconstituentsforthemanagementofrheumatoidarthritis AT kamlapathak nanotechnologybasedstrategiesforeffectivedeliveryofphytoconstituentsforthemanagementofrheumatoidarthritis AT suneeladhaneshwar nanotechnologybasedstrategiesforeffectivedeliveryofphytoconstituentsforthemanagementofrheumatoidarthritis |