Bactrian camels shed large quantities of Middle East respiratory syndrome coronavirus (MERS-CoV) after experimental infection
ABSTRACTIn 2012, Middle East respiratory syndrome coronavirus (MERS-CoV) emerged. To date, more than 2300 cases have been reported, with an approximate case fatality rate of 35%. Epidemiological investigations identified dromedary camels as the source of MERS-CoV zoonotic transmission and evidence o...
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| Materiálatiipa: | Artihkal |
| Giella: | English |
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Taylor & Francis Group
2019-01-01
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| Ráidu: | Emerging Microbes and Infections |
| Fáttát: | |
| Liŋkkat: | https://www.tandfonline.com/doi/10.1080/22221751.2019.1618687 |
| _version_ | 1827579247759196160 |
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| author | Danielle R. Adney Michael Letko Izabela K. Ragan Dana Scott Neeltje van Doremalen Richard A. Bowen Vincent J. Munster |
| author_facet | Danielle R. Adney Michael Letko Izabela K. Ragan Dana Scott Neeltje van Doremalen Richard A. Bowen Vincent J. Munster |
| author_sort | Danielle R. Adney |
| collection | DOAJ |
| description | ABSTRACTIn 2012, Middle East respiratory syndrome coronavirus (MERS-CoV) emerged. To date, more than 2300 cases have been reported, with an approximate case fatality rate of 35%. Epidemiological investigations identified dromedary camels as the source of MERS-CoV zoonotic transmission and evidence of MERS-CoV circulation has been observed throughout the original range of distribution. Other new-world camelids, alpacas and llamas, are also susceptible to MERS-CoV infection. Currently, it is unknown whether Bactrian camels are susceptible to infection. The distribution of Bactrian camels overlaps partly with that of the dromedary camel in west and central Asia. The receptor for MERS-CoV, DPP4, of the Bactrian camel was 98.3% identical to the dromedary camel DPP4, and 100% identical for the 14 residues which interact with the MERS-CoV spike receptor. Upon intranasal inoculation with 107 plaque-forming units of MERS-CoV, animals developed a transient, primarily upper respiratory tract infection. Clinical signs of the MERS-CoV infection were benign, but shedding of large quantities of MERS-CoV from the URT was observed. These data are similar to infections reported with dromedary camel infections and indicate that Bactrians are susceptible to MERS-CoV and given their overlapping range are at risk of introduction and establishment of MERS-CoV within the Bactrian camel populations. |
| first_indexed | 2024-03-08T21:58:58Z |
| format | Article |
| id | doaj.art-666e00cae59c4acbab5129c1499f1fc0 |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-03-08T21:58:58Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-666e00cae59c4acbab5129c1499f1fc02023-12-19T16:09:57ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512019-01-018171772310.1080/22221751.2019.1618687Bactrian camels shed large quantities of Middle East respiratory syndrome coronavirus (MERS-CoV) after experimental infectionDanielle R. Adney0Michael Letko1Izabela K. Ragan2Dana Scott3Neeltje van Doremalen4Richard A. Bowen5Vincent J. Munster6Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, USARocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USADepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO, USARocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USARocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USADepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO, USARocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USAABSTRACTIn 2012, Middle East respiratory syndrome coronavirus (MERS-CoV) emerged. To date, more than 2300 cases have been reported, with an approximate case fatality rate of 35%. Epidemiological investigations identified dromedary camels as the source of MERS-CoV zoonotic transmission and evidence of MERS-CoV circulation has been observed throughout the original range of distribution. Other new-world camelids, alpacas and llamas, are also susceptible to MERS-CoV infection. Currently, it is unknown whether Bactrian camels are susceptible to infection. The distribution of Bactrian camels overlaps partly with that of the dromedary camel in west and central Asia. The receptor for MERS-CoV, DPP4, of the Bactrian camel was 98.3% identical to the dromedary camel DPP4, and 100% identical for the 14 residues which interact with the MERS-CoV spike receptor. Upon intranasal inoculation with 107 plaque-forming units of MERS-CoV, animals developed a transient, primarily upper respiratory tract infection. Clinical signs of the MERS-CoV infection were benign, but shedding of large quantities of MERS-CoV from the URT was observed. These data are similar to infections reported with dromedary camel infections and indicate that Bactrians are susceptible to MERS-CoV and given their overlapping range are at risk of introduction and establishment of MERS-CoV within the Bactrian camel populations.https://www.tandfonline.com/doi/10.1080/22221751.2019.1618687MERS-CoVBactrian cameldromedary camelvirus sheddingnatural reservoir |
| spellingShingle | Danielle R. Adney Michael Letko Izabela K. Ragan Dana Scott Neeltje van Doremalen Richard A. Bowen Vincent J. Munster Bactrian camels shed large quantities of Middle East respiratory syndrome coronavirus (MERS-CoV) after experimental infection Emerging Microbes and Infections MERS-CoV Bactrian camel dromedary camel virus shedding natural reservoir |
| title | Bactrian camels shed large quantities of Middle East respiratory syndrome coronavirus (MERS-CoV) after experimental infection |
| title_full | Bactrian camels shed large quantities of Middle East respiratory syndrome coronavirus (MERS-CoV) after experimental infection |
| title_fullStr | Bactrian camels shed large quantities of Middle East respiratory syndrome coronavirus (MERS-CoV) after experimental infection |
| title_full_unstemmed | Bactrian camels shed large quantities of Middle East respiratory syndrome coronavirus (MERS-CoV) after experimental infection |
| title_short | Bactrian camels shed large quantities of Middle East respiratory syndrome coronavirus (MERS-CoV) after experimental infection |
| title_sort | bactrian camels shed large quantities of middle east respiratory syndrome coronavirus mers cov after experimental infection |
| topic | MERS-CoV Bactrian camel dromedary camel virus shedding natural reservoir |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2019.1618687 |
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