Reliability and Repeatability Analysis of Indices to Measure Gait Deterioration in MS Patients during Prolonged Walking
Gait deterioration caused by prolonged walking represents one of the main consequences of multiple sclerosis (MS). This study aims at proposing quantitative indices to measure the gait deterioration effects. The experimental protocol consisted in a 6-min walking test and it involved nine patients wi...
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MDPI AG
2020-09-01
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| Online Access: | https://www.mdpi.com/1424-8220/20/18/5063 |
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| author | Juri Taborri Valeria Studer Paola Grossi Laura Brambilla Fabrizio Patanè Maria Teresa Ferrò Renato Mantegazza Stefano Rossi |
| author_facet | Juri Taborri Valeria Studer Paola Grossi Laura Brambilla Fabrizio Patanè Maria Teresa Ferrò Renato Mantegazza Stefano Rossi |
| author_sort | Juri Taborri |
| collection | DOAJ |
| description | Gait deterioration caused by prolonged walking represents one of the main consequences of multiple sclerosis (MS). This study aims at proposing quantitative indices to measure the gait deterioration effects. The experimental protocol consisted in a 6-min walking test and it involved nine patients with MS and twenty-six healthy subjects. Pathology severity was assessed through the Expanded Disability Status Scale. Seven inertial units were used to gather lower limb kinematics. Gait variability and asymmetry were assessed by coefficient of variation (CoV) and symmetry index (SI), respectively. The evolution of ROM (range of motion), CoV, and SI was computed analyzing data divided into six 60-s subgroups. Maximum difference among subgroups and the difference between the first minute and the remaining five were computed. The indices were analyzed for intra- and inter-day reliability and repeatability. Correlation with clinical scores was also evaluated. Good to excellent reliability was found for all indices. The computed standard deviations allowed us to affirm the good repeatability of the indices. The outcomes suggested walking-related fatigue leads to an always more variable kinematics in MS, in terms of changes in ROM, increase of variability and asymmetry. The hip asymmetry strongly correlated with the clinical disability. |
| first_indexed | 2024-03-10T16:31:52Z |
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| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-03-10T16:31:52Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
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| series | Sensors |
| spelling | doaj.art-666e0e2d8f15430dbe355ea61d23bd372023-11-20T12:45:11ZengMDPI AGSensors1424-82202020-09-012018506310.3390/s20185063Reliability and Repeatability Analysis of Indices to Measure Gait Deterioration in MS Patients during Prolonged WalkingJuri Taborri0Valeria Studer1Paola Grossi2Laura Brambilla3Fabrizio Patanè4Maria Teresa Ferrò5Renato Mantegazza6Stefano Rossi7Department of Economics, Engineering, Society and Business Organization (DEIM), University of Tuscia, 01100 Viterbo, ItalyMultiple Sclerosis Center, Neurology Department, Martini Hospital, 10121 Turin, ItalyNeuroimmunology Center for Multiple Sclerosis, Cerebrovascular Department, ASST Crema, 52242 Crema, ItalyOperating Units of Autoimmune and Neuromuscular Diseases, IRCCS Foundation Neurological Institute Carlo Besta, 20133 Milano, ItalyDepartment of Engineering, Mech. Meas. and Microelectr.lab (M3lab), University Niccolò Cusano, 00166 Rome, ItalyNeuroimmunology Center for Multiple Sclerosis, Cerebrovascular Department, ASST Crema, 52242 Crema, ItalyOperating Units of Autoimmune and Neuromuscular Diseases, IRCCS Foundation Neurological Institute Carlo Besta, 20133 Milano, ItalyDepartment of Economics, Engineering, Society and Business Organization (DEIM), University of Tuscia, 01100 Viterbo, ItalyGait deterioration caused by prolonged walking represents one of the main consequences of multiple sclerosis (MS). This study aims at proposing quantitative indices to measure the gait deterioration effects. The experimental protocol consisted in a 6-min walking test and it involved nine patients with MS and twenty-six healthy subjects. Pathology severity was assessed through the Expanded Disability Status Scale. Seven inertial units were used to gather lower limb kinematics. Gait variability and asymmetry were assessed by coefficient of variation (CoV) and symmetry index (SI), respectively. The evolution of ROM (range of motion), CoV, and SI was computed analyzing data divided into six 60-s subgroups. Maximum difference among subgroups and the difference between the first minute and the remaining five were computed. The indices were analyzed for intra- and inter-day reliability and repeatability. Correlation with clinical scores was also evaluated. Good to excellent reliability was found for all indices. The computed standard deviations allowed us to affirm the good repeatability of the indices. The outcomes suggested walking-related fatigue leads to an always more variable kinematics in MS, in terms of changes in ROM, increase of variability and asymmetry. The hip asymmetry strongly correlated with the clinical disability.https://www.mdpi.com/1424-8220/20/18/5063reliabilityrepeatabilitysynthetic indicesmultiple sclerosis6-min walking testfatigue |
| spellingShingle | Juri Taborri Valeria Studer Paola Grossi Laura Brambilla Fabrizio Patanè Maria Teresa Ferrò Renato Mantegazza Stefano Rossi Reliability and Repeatability Analysis of Indices to Measure Gait Deterioration in MS Patients during Prolonged Walking Sensors reliability repeatability synthetic indices multiple sclerosis 6-min walking test fatigue |
| title | Reliability and Repeatability Analysis of Indices to Measure Gait Deterioration in MS Patients during Prolonged Walking |
| title_full | Reliability and Repeatability Analysis of Indices to Measure Gait Deterioration in MS Patients during Prolonged Walking |
| title_fullStr | Reliability and Repeatability Analysis of Indices to Measure Gait Deterioration in MS Patients during Prolonged Walking |
| title_full_unstemmed | Reliability and Repeatability Analysis of Indices to Measure Gait Deterioration in MS Patients during Prolonged Walking |
| title_short | Reliability and Repeatability Analysis of Indices to Measure Gait Deterioration in MS Patients during Prolonged Walking |
| title_sort | reliability and repeatability analysis of indices to measure gait deterioration in ms patients during prolonged walking |
| topic | reliability repeatability synthetic indices multiple sclerosis 6-min walking test fatigue |
| url | https://www.mdpi.com/1424-8220/20/18/5063 |
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