Expanding roles of circRNAs in cardiovascular diseases
CircRNAs are a class of single-stranded RNAs characterized by covalently looped structures. Emerging advances have promoted our understanding of circRNA biogenesis, nuclear export, biological functions, and functional mechanisms. Roles of circRNAs in diverse diseases have been increasingly recognize...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-06-01
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| Series: | Non-coding RNA Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468054024000222 |
| _version_ | 1797234042462011392 |
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| author | Xu Liu Xuelin Yao Liang Chen |
| author_facet | Xu Liu Xuelin Yao Liang Chen |
| author_sort | Xu Liu |
| collection | DOAJ |
| description | CircRNAs are a class of single-stranded RNAs characterized by covalently looped structures. Emerging advances have promoted our understanding of circRNA biogenesis, nuclear export, biological functions, and functional mechanisms. Roles of circRNAs in diverse diseases have been increasingly recognized in the past decade, with novel approaches in bioinformatics analysis and new strategies in modulating circRNA levels, which have made circRNAs the hot spot for therapeutic applications. Moreover, due to the intrinsic features of circRNAs such as high stability, conservation, and tissue-/stage-specific expression, circRNAs are believed to be promising prognostic and diagnostic markers for diseases. Aiming cardiovascular disease (CVD), one of the leading causes of mortality worldwide, we briefly summarize the current understanding of circRNAs, provide the recent progress in circRNA functions and functional mechanisms in CVD, and discuss the future perspectives both in circRNA research and therapeutics based on existing knowledge. |
| first_indexed | 2024-04-24T16:25:46Z |
| format | Article |
| id | doaj.art-666ed27068b04080b1813d0b504b1cb7 |
| institution | Directory Open Access Journal |
| issn | 2468-0540 |
| language | English |
| last_indexed | 2024-04-24T16:25:46Z |
| publishDate | 2024-06-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Non-coding RNA Research |
| spelling | doaj.art-666ed27068b04080b1813d0b504b1cb72024-03-31T04:37:49ZengKeAi Communications Co., Ltd.Non-coding RNA Research2468-05402024-06-0192429436Expanding roles of circRNAs in cardiovascular diseasesXu Liu0Xuelin Yao1Liang Chen2Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, ChinaDepartment of Endocrinology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China; Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, ChinaDepartment of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China; Corresponding author.CircRNAs are a class of single-stranded RNAs characterized by covalently looped structures. Emerging advances have promoted our understanding of circRNA biogenesis, nuclear export, biological functions, and functional mechanisms. Roles of circRNAs in diverse diseases have been increasingly recognized in the past decade, with novel approaches in bioinformatics analysis and new strategies in modulating circRNA levels, which have made circRNAs the hot spot for therapeutic applications. Moreover, due to the intrinsic features of circRNAs such as high stability, conservation, and tissue-/stage-specific expression, circRNAs are believed to be promising prognostic and diagnostic markers for diseases. Aiming cardiovascular disease (CVD), one of the leading causes of mortality worldwide, we briefly summarize the current understanding of circRNAs, provide the recent progress in circRNA functions and functional mechanisms in CVD, and discuss the future perspectives both in circRNA research and therapeutics based on existing knowledge.http://www.sciencedirect.com/science/article/pii/S2468054024000222Circular RNAsCardiovascular diseaseFunctional rolesTherapeutic strategy |
| spellingShingle | Xu Liu Xuelin Yao Liang Chen Expanding roles of circRNAs in cardiovascular diseases Non-coding RNA Research Circular RNAs Cardiovascular disease Functional roles Therapeutic strategy |
| title | Expanding roles of circRNAs in cardiovascular diseases |
| title_full | Expanding roles of circRNAs in cardiovascular diseases |
| title_fullStr | Expanding roles of circRNAs in cardiovascular diseases |
| title_full_unstemmed | Expanding roles of circRNAs in cardiovascular diseases |
| title_short | Expanding roles of circRNAs in cardiovascular diseases |
| title_sort | expanding roles of circrnas in cardiovascular diseases |
| topic | Circular RNAs Cardiovascular disease Functional roles Therapeutic strategy |
| url | http://www.sciencedirect.com/science/article/pii/S2468054024000222 |
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