Biocompatible Phosphorescent O<sub>2</sub> Sensors Based on Ir(III) Complexes for In Vivo Hypoxia Imaging

Biocompatible Phosphorescent O<sub>2</sub> Sensors Based on Ir(III) Complexes for In Vivo Hypoxia Imaging

In this work, we obtained three new phosphorescent iridium complexes (<b>Ir1</b>–<b>Ir3</b>) of general stoichiometry [Ir(N^C)<sub>2</sub>(N^N)]Cl decorated with oligo(ethylene glycol) fragments to make them water-soluble and biocompatible, as well as to protect t...

Full description

Bibliographic Details
Main Authors:	Mozhgan Samandarsangari, Daria O. Kozina, Victor V. Sokolov, Anastasia D. Komarova, Marina V. Shirmanova, Ilya S. Kritchenkov, Sergey P. Tunik
Format:	Article
Language:	English
Published:	MDPI AG 2023-06-01
Series:	Biosensors
Subjects:	oxygen sensing iridium complexes phosphorescence hypoxia bioimaging phosphorescence lifetime imaging
Online Access:	https://www.mdpi.com/2079-6374/13/7/680

Similar Items

Phosphorescent O<sub>2</sub>-Probes Based on Ir(III) Complexes for Bioimaging Applications
by: Mozhgan Samandarsangari, et al.
Published: (2023-04-01)

Novel NIR-Phosphorescent Ir(III) Complexes: Synthesis, Characterization and Their Exploration as Lifetime-Based O<sub>2</sub> Sensors in Living Cells
by: Ilya S. Kritchenkov, et al.
Published: (2022-05-01)

Simultaneous Probing of Metabolism and Oxygenation of Tumors In Vivo Using FLIM of NAD(P)H and PLIM of a New Polymeric Ir(III) Oxygen Sensor
by: Yulia P. Parshina, et al.
Published: (2022-09-01)

Biocompatible Ir(III) Complexes as Oxygen Sensors for Phosphorescence Lifetime Imaging
by: Ilya S. Kritchenkov, et al.
Published: (2021-05-01)

Red Light-Emitting Water-Soluble Luminescent Iridium-Containing Polynorbornenes: Synthesis, Characterization and Oxygen Sensing Properties in Biological Tissues In Vivo
by: Leonid N. Bochkarev, et al.
Published: (2021-10-01)

Investigation of the N^C Ligand Effects on Emission Characteristics in a Series of Bis-Metalated [Ir(N^C)<sub>2</sub>(N^N)]<sup>+</sup> Complexes
by: Zohreh Hendi, et al.
Published: (2023-03-01)

pH-Responsive N^C-Cyclometalated Iridium(III) Complexes: Synthesis, Photophysical Properties, Computational Results, and Bioimaging Application
by: Anastasia I. Solomatina, et al.
Published: (2021-12-01)

Studies on the photodegradation of red, green and blue phosphorescent OLED emitters
by: Susanna Schmidbauer, et al.
Published: (2013-10-01)

Yellow Phosphorescent Electrogenerated Chemiluminescence Cell Based on a Cyclometalated Iridium Complex with a Redox Mediator
by: Nanami ICHINOHE, et al.
Published: (2024-02-01)

Phosphorimetry: the application of phosphorescence to the analysis of organic compounds/
by: 246414 Zander, Maximilian
Published: (1968)

A Novel Phosphorescent Iridium(III) Complex Bearing Formamide for Quantitative Fluorine Anion Detection
by: Song Guo, et al.
Published: (2021-09-01)

Functionalizing Collagen with Vessel‐Penetrating Two‐Photon Phosphorescence Probes: A New In Vivo Strategy to Map Oxygen Concentration in Tumor Microenvironment and Tissue Ischemia
by: Cheng‐Ham Wu, et al.
Published: (2021-10-01)

New [3+2+1] Iridium Complexes as Effective Phosphorescent Sensitizers for Efficient Narrowband Saturated–Blue Hyper–OLEDs
by: Chengcheng Wu, et al.
Published: (2023-10-01)

Light-Addressable Measurement of in Vivo Tissue Oxygenation in an Unanesthetized Zebrafish Embryo via Phase-Based Phosphorescence Lifetime Detection
by: Shih-Hao Huang, et al.
Published: (2015-04-01)

Tuning the Photophysical and Excited State Properties of Phosphorescent Iridium(III) Complexes by Polycyclic Unit Substitution
by: Cuicui Wu, et al.
Published: (2019-03-01)

Effects of Photodynamic Therapy on Tumor Metabolism and Oxygenation Revealed by Fluorescence and Phosphorescence Lifetime Imaging
by: Marina V. Shirmanova, et al.
Published: (2024-01-01)

Fluorescence and phosphorescence spectroscopy: physicochemical principles and practice/
by: 171103 Schulman, Stephen G.
Published: (1976)

Manipulating intermolecular interactions for ultralong organic phosphorescence
by: Suzhi Cai, et al.
Published: (2023-06-01)

Biocompatible Probes Based on Rare-Earth Doped Strontium Aluminates with Long-Lasting Phosphorescent Properties for In Vitro Optical IMAGING
by: David G. Calatayud, et al.
Published: (2022-03-01)

Deep NIR-I Emissive Iridium(III) Complex Bearing D-A Ligand: Synthesis, Photophysical Properties and DFT/TDDFT Calculation
by: Jia-Yang Jiang, et al.
Published: (2021-08-01)

Vacuum–Sublimable Ionic Yellow Phosphorescent Iridium(III) Complexes with Broad Emission for White Electroluminescence
by: Peng Tao, et al.
Published: (2021-11-01)

Two Novel Neutral Cyclometalated Iridium(III) Complexes Based on 10,11,12,13-Tetrahydrodibenzo[a,c]phenazine for Efficient Red Electroluminescence
by: Yuzhen Yang, et al.
Published: (2023-06-01)

Carbazole-based aggregation-induced phosphorescent emission-active gold(I) complexes with various phosphorescent mechanochromisms
by: Zhao Chen, et al.
Published: (2022-12-01)

Cross‐linking enhanced room‐temperature phosphorescence of carbon dots
by: Boyang Wang, et al.
Published: (2022-06-01)

Rational Design of Mono- and Bi-Nuclear Cyclometalated Ir(III) Complexes Containing Di-Pyridylamine Motifs: Synthesis, Structure, and Luminescent Properties
by: Hugo Sesolis, et al.
Published: (2022-09-01)

Metal-Organic Cages Based on Phosphorescent Organometallics
by: Yunliang Yu, et al.
Published: (2023-11-01)

Probing defects in ZnO by persistent phosphorescence
by: Ye Honggang, et al.
Published: (2018-07-01)

Theoretical Insight Into the Ultralong Room-Temperature Phosphorescence of Nonplanar Aromatic Hydrocarbon
by: Ke Qin, et al.
Published: (2021-09-01)

Phosphorescence of Carbon Dot: The Intrinsic Mechanism and Recent Progress
by: Kun Zuo, et al.
Published: (2023-09-01)

Ratiometric Molecular Probes Based on Dual Emission of a Blue Fluorescent Coumarin and a Red Phosphorescent Cationic Iridium(III) Complex for Intracellular Oxygen Sensing
by: Toshitada Yoshihara, et al.
Published: (2015-06-01)

Effects of Substitution Position of Carbazole-Dibenzofuran Based High Triplet Energy Hosts to Device Stability of Blue Phosphorescent Organic Light-Emitting Diodes
by: Kyung Hyun Choi, et al.
Published: (2021-05-01)

Synthesis, Spectroscopy and Electrochemistry in Relation to DFT Computed Energies of Ferrocene- and Ruthenocene-Containing β-Diketonato Iridium(III) Heteroleptic Complexes. Structure of [(2-Pyridylphenyl)<sub>2</sub>Ir(RcCOCHCOCH<sub>3</sub>]
by: Blenerhassitt E. Buitendach, et al.
Published: (2019-10-01)

A Highly Efficient Phosphorescence/Fluorescence Supramolecular Switch Based on a Bromoisoquinoline Cascaded Assembly in Aqueous Solution
by: Xian‐Yin Dai, et al.
Published: (2022-05-01)

Polymeric ultralong organic phosphorescence with excellent humidity and temperature resistance via hydrophobic effect
by: Zhongyu Li, et al.
Published: (2024-04-01)

Synthesis and characterization of hollow mesoporous silica nanocomposites containing phosphorescent pigment and doxycycline
by: Zahra Alam, et al.
Published: (2023-03-01)

A Versatile Multichannel Instrument for Measurement of Ratiometric Fluorescence Intensity and Phosphorescence Lifetime
by: Amir Tofighi Zavareh, et al.
Published: (2021-01-01)

Long Persistent Luminescent HDPE Composites with Strontium Aluminate and Their Phosphorescence, Thermal, Mechanical, and Rheological Characteristics
by: Anesh Manjaly Poulose, et al.
Published: (2022-02-01)

A pilot study of the dynamics of tissue oxygenation in vivo using time-resolved phosphorescence imaging
by: Natalia Kazachkina, et al.
Published: (2021-09-01)

Heavy main group element containing organometallic phosphorescent materials
by: S. Arunkumar, et al.
Published: (2022-01-01)

Phosphorescent mono- and diiridium(III) complexes cyclometalated by fluorenyl- or phenyl-pyridino ligands with bulky substituents, as prospective OLED dopants
by: Ahmed M'hamedi, et al.
Published: (2020-03-01)