Direct spectrofluorimetric methods as alternatives to compendial ones used for the quality control of biopharmaceuticals: development, validation and application

Direct spectrofluorimetric methods as alternatives to compendial ones used for the quality control of biopharmaceuticals: development, validation and application

Abstract A simple, rapid, precise, accurate and sustainable spectrofluorimetric method (SFM) was developed, validated and applied for the determination of 4-aminobenzoic acid and aromatic amino acids (phenylalanine, tryptophan and tyrosine). These compounds are used in biopharmaceutical formulations...

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Bibliographic Details
Main Authors: Thallis Martins Souza, Robert da Silva Angelino, Larissa Manhães Ornella, Eduardo dos Santos Ribeiro, Simone Ferreira Rodrigues Fernandes
Format: Article
Language:English
Published: Universidade de São Paulo 2024-02-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
4-aminobenzoic acid
Analytical validation
Aromatic amino acids
Fluorescence spectroscopy
Raw material
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502024000100301&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502024000100301&lng=en&tlng=en

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