Simultaneous Determination of Glibenclamide and Silymarin Released from Chitosan Microparticles by HPLC-ESI-MS Technique: Method Development and Validation

Simultaneous Determination of Glibenclamide and Silymarin Released from Chitosan Microparticles by HPLC-ESI-MS Technique: Method Development and Validation

The study aim was to develop and validate a high-performance liquid chromatography–electrospray ionization mass spectrometry (HPLC-ESI-MS) method to simultaneously determine glibenclamide (Gli) and silymarin (Sil) released from chitosan (CS) microparticles in aqueous solutions. The CS microparticles...

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Bibliographic Details
Main Authors: Mihaela-Iustina Condurache, Anca-Roxana Petrovici, Natalia Simionescu, Bianca-Stefania Profire, Luminita-Georgeta Confederat, Alexandra Bujor, Anca Miron, Lenuta Profire
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Pharmaceutics
Subjects:
chitosan microparticles
glibenclamide
silymarin
HPLC-ESI-MS method development and validation
Online Access:https://www.mdpi.com/1999-4923/14/10/2164

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