Helicobacter pylori, clinical, laboratory, and noninvasive biomarkers suggestive of gastric damage in healthy school-aged children: A case-control study
Background: Helicobacter pylori is acquired largely in early childhood, but its association with symptoms and indirect biomarkers of gastric damage in apparently healthy children remains controversial. We aimed to relate persistent H. pylori infection in apparently healthy school-aged children with...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-02-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971220325182 |
| _version_ | 1818324614417219584 |
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| author | Yalda Lucero Anne J. Lagomarcino Juan P. Torres Patricia Roessler Nora Mamani Sergio George Nicole Huerta Monica Gonzalez Miguel O’Ryan |
| author_facet | Yalda Lucero Anne J. Lagomarcino Juan P. Torres Patricia Roessler Nora Mamani Sergio George Nicole Huerta Monica Gonzalez Miguel O’Ryan |
| author_sort | Yalda Lucero |
| collection | DOAJ |
| description | Background: Helicobacter pylori is acquired largely in early childhood, but its association with symptoms and indirect biomarkers of gastric damage in apparently healthy children remains controversial. We aimed to relate persistent H. pylori infection in apparently healthy school-aged children with clinical, laboratory, and noninvasive biomarkers suggestive of gastric damage using a case-control design. Materials and methods: We followed up 83 children aged 4–5 years with persistent H. pylori infection determined by stool antigen detection and/or a urea breath test and 80 noninfected matched controls from a low-income to middle-income, periurban city in Chile for at least 3 years. Monitoring included clinical visits every 4 months and annual assessment by a pediatric gastroenterologist. A blood sample was obtained to determine laboratory parameters potentially associated with gastric damage (hemogram and serum iron and ferritin levels), biomarkers of inflammation (cytokines, pepsinogens I and II, and tissue inhibitor metalloproteinase 1), and expression of cancer-related genes KLK1, BTG3, and SLC5A8. Results: Persistently infected children had higher frequency of epigastric pain on physical examination (40% versus 16%; P = 0.001), especially from 8 to 10 years of age. No differences in anthropometric measurements or iron-deficiency parameters were found. Persistent infection was associated with higher levels of pepsinogen II (median 12.7 ng/mL versus 9.0 ng/mL; P < 0.001); no difference was observed in other biomarkers or gene expression profiles. Conclusions: H. pylori infection in apparently asymptomatic school-aged children is associated with an increase in clinical symptoms and in the level of one significant biomarker, pepsinogen II, suggesting early gastric involvement. |
| first_indexed | 2024-12-13T11:31:23Z |
| format | Article |
| id | doaj.art-666fb82a5b604f4c9a9cd630b590f6b1 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-13T11:31:23Z |
| publishDate | 2021-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-666fb82a5b604f4c9a9cd630b590f6b12022-12-21T23:47:54ZengElsevierInternational Journal of Infectious Diseases1201-97122021-02-01103423430Helicobacter pylori, clinical, laboratory, and noninvasive biomarkers suggestive of gastric damage in healthy school-aged children: A case-control studyYalda Lucero0Anne J. Lagomarcino1Juan P. Torres2Patricia Roessler3Nora Mamani4Sergio George5Nicole Huerta6Monica Gonzalez7Miguel O’Ryan8Microbiology and Mycology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Av. Independencia 1027, Independencia, Santiago, Chile; Hospital Dr. Roberto del Río, Department of Pediatrics and Pediatric Surgery (Northern Campus), Faculty of Medicine, Universidad de Chile, Profesor Zañartu 1085, Independencia, Santiago, Chile; Clínica Alemana de Santiago, Faculty of Medicine, Universidad del Desarrollo-Clínica Alemana, Av. Vitacura 5951, Vitacura, Santiago, ChileMicrobiology and Mycology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Av. Independencia 1027, Independencia, Santiago, ChileHospital Dr. Luis Calvo Mackenna, Department of Pediatrics and Pediatric Surgery (Eastern Campus), Faculty of Medicine, Universidad de Chile, Antonio Varas 360, Providencia, Santiago, ChileClínica Alemana de Santiago, Faculty of Medicine, Universidad del Desarrollo-Clínica Alemana, Av. Vitacura 5951, Vitacura, Santiago, ChileMicrobiology and Mycology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Av. Independencia 1027, Independencia, Santiago, ChileMicrobiology and Mycology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Av. Independencia 1027, Independencia, Santiago, Chile; Hospital Dr. Luis Calvo Mackenna, Department of Pediatrics and Pediatric Surgery (Eastern Campus), Faculty of Medicine, Universidad de Chile, Antonio Varas 360, Providencia, Santiago, ChileMicrobiology and Mycology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Av. Independencia 1027, Independencia, Santiago, ChileHospital Dr. Roberto del Río, Department of Pediatrics and Pediatric Surgery (Northern Campus), Faculty of Medicine, Universidad de Chile, Profesor Zañartu 1085, Independencia, Santiago, ChileMicrobiology and Mycology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Av. Independencia 1027, Independencia, Santiago, Chile; Millennium Institute on Immunology and Immunotherapy, Faculty of Medicine, Universidad de Chile, Av. Independencia 1027, Independencia, Santiago, Chile; Corresponding author.Background: Helicobacter pylori is acquired largely in early childhood, but its association with symptoms and indirect biomarkers of gastric damage in apparently healthy children remains controversial. We aimed to relate persistent H. pylori infection in apparently healthy school-aged children with clinical, laboratory, and noninvasive biomarkers suggestive of gastric damage using a case-control design. Materials and methods: We followed up 83 children aged 4–5 years with persistent H. pylori infection determined by stool antigen detection and/or a urea breath test and 80 noninfected matched controls from a low-income to middle-income, periurban city in Chile for at least 3 years. Monitoring included clinical visits every 4 months and annual assessment by a pediatric gastroenterologist. A blood sample was obtained to determine laboratory parameters potentially associated with gastric damage (hemogram and serum iron and ferritin levels), biomarkers of inflammation (cytokines, pepsinogens I and II, and tissue inhibitor metalloproteinase 1), and expression of cancer-related genes KLK1, BTG3, and SLC5A8. Results: Persistently infected children had higher frequency of epigastric pain on physical examination (40% versus 16%; P = 0.001), especially from 8 to 10 years of age. No differences in anthropometric measurements or iron-deficiency parameters were found. Persistent infection was associated with higher levels of pepsinogen II (median 12.7 ng/mL versus 9.0 ng/mL; P < 0.001); no difference was observed in other biomarkers or gene expression profiles. Conclusions: H. pylori infection in apparently asymptomatic school-aged children is associated with an increase in clinical symptoms and in the level of one significant biomarker, pepsinogen II, suggesting early gastric involvement.http://www.sciencedirect.com/science/article/pii/S1201971220325182Helicobacter pyloriChildrenPersistent infectionGastric damagePepsinogen |
| spellingShingle | Yalda Lucero Anne J. Lagomarcino Juan P. Torres Patricia Roessler Nora Mamani Sergio George Nicole Huerta Monica Gonzalez Miguel O’Ryan Helicobacter pylori, clinical, laboratory, and noninvasive biomarkers suggestive of gastric damage in healthy school-aged children: A case-control study International Journal of Infectious Diseases Helicobacter pylori Children Persistent infection Gastric damage Pepsinogen |
| title | Helicobacter pylori, clinical, laboratory, and noninvasive biomarkers suggestive of gastric damage in healthy school-aged children: A case-control study |
| title_full | Helicobacter pylori, clinical, laboratory, and noninvasive biomarkers suggestive of gastric damage in healthy school-aged children: A case-control study |
| title_fullStr | Helicobacter pylori, clinical, laboratory, and noninvasive biomarkers suggestive of gastric damage in healthy school-aged children: A case-control study |
| title_full_unstemmed | Helicobacter pylori, clinical, laboratory, and noninvasive biomarkers suggestive of gastric damage in healthy school-aged children: A case-control study |
| title_short | Helicobacter pylori, clinical, laboratory, and noninvasive biomarkers suggestive of gastric damage in healthy school-aged children: A case-control study |
| title_sort | helicobacter pylori clinical laboratory and noninvasive biomarkers suggestive of gastric damage in healthy school aged children a case control study |
| topic | Helicobacter pylori Children Persistent infection Gastric damage Pepsinogen |
| url | http://www.sciencedirect.com/science/article/pii/S1201971220325182 |
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