Clinical and Associated Immunological Manifestations of HFMD Caused by Different Viral Infections in Children
Hand, foot, and mouth disease (HFMD), with vesiculae on the hands, feet and mouth, is an infectious disease caused by many viral pathogens. However, the differences of immune response induced by these pathogens are unclear. We compared the clinical manifestations and the levels of immunologic indica...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2016-05-01
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| Series: | Global Pediatric Health |
| Online Access: | https://doi.org/10.1177/2333794X16643723 |
| _version_ | 1819204117102329856 |
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| author | Jingjing Wang MS Jing Pu PhD Longding Liu PhD Yanchun Che MS Yun Liao Lichun Wang Lei Guo PhD Min Feng PhD Yan Liang PhD Shengtao Fan PhD Lukui Cai MS Ying Zhang PhD Qihan Li PhD, MD |
| author_facet | Jingjing Wang MS Jing Pu PhD Longding Liu PhD Yanchun Che MS Yun Liao Lichun Wang Lei Guo PhD Min Feng PhD Yan Liang PhD Shengtao Fan PhD Lukui Cai MS Ying Zhang PhD Qihan Li PhD, MD |
| author_sort | Jingjing Wang MS |
| collection | DOAJ |
| description | Hand, foot, and mouth disease (HFMD), with vesiculae on the hands, feet and mouth, is an infectious disease caused by many viral pathogens. However, the differences of immune response induced by these pathogens are unclear. We compared the clinical manifestations and the levels of immunologic indicators from 60 HFMD patients caused by different viral pathogens to analyze the differences in the immune response. It was shown that Th2 cytokines (IL-4 and IL-10) increased significantly in EV71-infected children; Th1 cytokines (IL-2 and IFN-γ) rose in CA16-infected children; both Th1 and Th2 cytokines elevated in non-EVG-infected children; only individual cytokines (such as IL-10) went up in EVG-infected children. Meanwhile, the antibodies induced by viral infection could not cross-interfere between the different pathogens. These differences might be due to variations in the immune response induced by the individual pathogens or to the pathogenesis of the infections by the individual pathogens. |
| first_indexed | 2024-12-23T04:30:42Z |
| format | Article |
| id | doaj.art-6670da2e42c24251b43d9173e32d314c |
| institution | Directory Open Access Journal |
| issn | 2333-794X |
| language | English |
| last_indexed | 2024-12-23T04:30:42Z |
| publishDate | 2016-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Global Pediatric Health |
| spelling | doaj.art-6670da2e42c24251b43d9173e32d314c2022-12-21T18:00:02ZengSAGE PublishingGlobal Pediatric Health2333-794X2016-05-01310.1177/2333794X1664372310.1177_2333794X16643723Clinical and Associated Immunological Manifestations of HFMD Caused by Different Viral Infections in ChildrenJingjing Wang MS0Jing Pu PhD1Longding Liu PhD2Yanchun Che MS3Yun Liao4Lichun Wang5Lei Guo PhD6Min Feng PhD7Yan Liang PhD8Shengtao Fan PhD9Lukui Cai MS10Ying Zhang PhD11Qihan Li PhD, MD12Institute of Medical Biology, Chinese Academy of Medicine Sciences, Kunming, Yunnan, ChinaInstitute of Medical Biology, Chinese Academy of Medicine Sciences, Kunming, Yunnan, ChinaInstitute of Medical Biology, Chinese Academy of Medicine Sciences, Kunming, Yunnan, ChinaInstitute of Medical Biology, Chinese Academy of Medicine Sciences, Kunming, Yunnan, ChinaInstitute of Medical Biology, Chinese Academy of Medicine Sciences, Kunming, Yunnan, ChinaInstitute of Medical Biology, Chinese Academy of Medicine Sciences, Kunming, Yunnan, ChinaInstitute of Medical Biology, Chinese Academy of Medicine Sciences, Kunming, Yunnan, ChinaInstitute of Medical Biology, Chinese Academy of Medicine Sciences, Kunming, Yunnan, ChinaInstitute of Medical Biology, Chinese Academy of Medicine Sciences, Kunming, Yunnan, ChinaInstitute of Medical Biology, Chinese Academy of Medicine Sciences, Kunming, Yunnan, ChinaInstitute of Medical Biology, Chinese Academy of Medicine Sciences, Kunming, Yunnan, ChinaInstitute of Medical Biology, Chinese Academy of Medicine Sciences, Kunming, Yunnan, ChinaInstitute of Medical Biology, Chinese Academy of Medicine Sciences, Kunming, Yunnan, ChinaHand, foot, and mouth disease (HFMD), with vesiculae on the hands, feet and mouth, is an infectious disease caused by many viral pathogens. However, the differences of immune response induced by these pathogens are unclear. We compared the clinical manifestations and the levels of immunologic indicators from 60 HFMD patients caused by different viral pathogens to analyze the differences in the immune response. It was shown that Th2 cytokines (IL-4 and IL-10) increased significantly in EV71-infected children; Th1 cytokines (IL-2 and IFN-γ) rose in CA16-infected children; both Th1 and Th2 cytokines elevated in non-EVG-infected children; only individual cytokines (such as IL-10) went up in EVG-infected children. Meanwhile, the antibodies induced by viral infection could not cross-interfere between the different pathogens. These differences might be due to variations in the immune response induced by the individual pathogens or to the pathogenesis of the infections by the individual pathogens.https://doi.org/10.1177/2333794X16643723 |
| spellingShingle | Jingjing Wang MS Jing Pu PhD Longding Liu PhD Yanchun Che MS Yun Liao Lichun Wang Lei Guo PhD Min Feng PhD Yan Liang PhD Shengtao Fan PhD Lukui Cai MS Ying Zhang PhD Qihan Li PhD, MD Clinical and Associated Immunological Manifestations of HFMD Caused by Different Viral Infections in Children Global Pediatric Health |
| title | Clinical and Associated Immunological Manifestations of HFMD Caused by Different Viral Infections in Children |
| title_full | Clinical and Associated Immunological Manifestations of HFMD Caused by Different Viral Infections in Children |
| title_fullStr | Clinical and Associated Immunological Manifestations of HFMD Caused by Different Viral Infections in Children |
| title_full_unstemmed | Clinical and Associated Immunological Manifestations of HFMD Caused by Different Viral Infections in Children |
| title_short | Clinical and Associated Immunological Manifestations of HFMD Caused by Different Viral Infections in Children |
| title_sort | clinical and associated immunological manifestations of hfmd caused by different viral infections in children |
| url | https://doi.org/10.1177/2333794X16643723 |
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