Colocalized targeting of TGF-β and PD-L1 by bintrafusp alfa elicits distinct antitumor responses

Colocalized targeting of TGF-β and PD-L1 by bintrafusp alfa elicits distinct antitumor responses

Background Bintrafusp alfa (BA) is a bifunctional fusion protein designed for colocalized, simultaneous inhibition of two immunosuppressive pathways, transforming growth factor-β (TGF-β) and programmed death-ligand 1 (PD-L1), within the tumor microenvironment (TME). We hypothesized that targeting PD...

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Bibliographic Details
Main Authors: Feng Jiang, Hong Wang, Yan Lan, Guozhong Qin, Jin Qi, Bo Marelli, Huakui Yu, Kin-Ming Lo, Dong Zhang, Hui Huang, Hong Ma, Tsz-Lun Yeung, Ansgar A Wegener, Somdutta Saha, Mira Toister-Achituv, Molly H Jenkins, Li-Ya Chiu, Adam Lazorchak, Ohad Tarcic, George Locke, Doron Kalimi, Alec W Gross, Melissa G Derner, Maria Soloviev, Mathieu Botte, Aroop Sircar, Vanita D Sood
Format: Article
Language:English
Published: BMJ Publishing Group 2022-07-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/10/7/e004122.full

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