Research progress on the mechanism of orexin in pain regulation in different brain regions
Orexin is a neuropeptide that is primarily synthesized and secreted by the lateral hypothalamus (LH) and includes two substances derived from the same precursor (orexin A [OXA] and orexin B [OXB]). Studies have shown that orexin is not only involved in the regulation of eating, the sleep–wake cycle,...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2021-01-01
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| Series: | Open Life Sciences |
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| Online Access: | https://doi.org/10.1515/biol-2021-0001 |
| _version_ | 1828381349707251712 |
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| author | Kang Xianhui Tang Hongli Liu Yao Yuan Yan Wang Mi |
| author_facet | Kang Xianhui Tang Hongli Liu Yao Yuan Yan Wang Mi |
| author_sort | Kang Xianhui |
| collection | DOAJ |
| description | Orexin is a neuropeptide that is primarily synthesized and secreted by the lateral hypothalamus (LH) and includes two substances derived from the same precursor (orexin A [OXA] and orexin B [OXB]). Studies have shown that orexin is not only involved in the regulation of eating, the sleep–wake cycle, and energy metabolism, but also closely associated with various physiological functions, such as cardiovascular control, reproduction, stress, reward, addiction, and the modulation of pain transmission. At present, studies that have been performed both domestically and abroad have confirmed that orexin and its receptors are closely associated with pain regulation. In this article, the research progress on acute pain regulation involving orexin is reviewed. |
| first_indexed | 2024-12-10T04:13:51Z |
| format | Article |
| id | doaj.art-66738fcdd6c347d59f13d577b3ac3f0d |
| institution | Directory Open Access Journal |
| issn | 2391-5412 |
| language | English |
| last_indexed | 2024-12-10T04:13:51Z |
| publishDate | 2021-01-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Life Sciences |
| spelling | doaj.art-66738fcdd6c347d59f13d577b3ac3f0d2022-12-22T02:02:39ZengDe GruyterOpen Life Sciences2391-54122021-01-01161465210.1515/biol-2021-0001biol-2021-0001Research progress on the mechanism of orexin in pain regulation in different brain regionsKang Xianhui0Tang Hongli1Liu Yao2Yuan Yan3Wang Mi4Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province 310003, ChinaDepartment of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou City, Zhejiang Province 325000, ChinaDepartment of Pain Management, Jiangnan University, No.1000 Hefeng Road, Binhu District, Wuxi, Jiangsu Province 214000, People’s Republic of ChinaDepartment of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, No. 84 Huaihai West Road, Quanshan District, Xuzhou, Jiangsu Province 221002, People’s Republic of ChinaDepartment of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, No. 84 Huaihai West Road, Quanshan District, Xuzhou, Jiangsu Province 221002, People’s Republic of ChinaOrexin is a neuropeptide that is primarily synthesized and secreted by the lateral hypothalamus (LH) and includes two substances derived from the same precursor (orexin A [OXA] and orexin B [OXB]). Studies have shown that orexin is not only involved in the regulation of eating, the sleep–wake cycle, and energy metabolism, but also closely associated with various physiological functions, such as cardiovascular control, reproduction, stress, reward, addiction, and the modulation of pain transmission. At present, studies that have been performed both domestically and abroad have confirmed that orexin and its receptors are closely associated with pain regulation. In this article, the research progress on acute pain regulation involving orexin is reviewed.https://doi.org/10.1515/biol-2021-0001orexinsorexin apain regulationorexin receptorsacute pain |
| spellingShingle | Kang Xianhui Tang Hongli Liu Yao Yuan Yan Wang Mi Research progress on the mechanism of orexin in pain regulation in different brain regions Open Life Sciences orexins orexin a pain regulation orexin receptors acute pain |
| title | Research progress on the mechanism of orexin in pain regulation in different brain regions |
| title_full | Research progress on the mechanism of orexin in pain regulation in different brain regions |
| title_fullStr | Research progress on the mechanism of orexin in pain regulation in different brain regions |
| title_full_unstemmed | Research progress on the mechanism of orexin in pain regulation in different brain regions |
| title_short | Research progress on the mechanism of orexin in pain regulation in different brain regions |
| title_sort | research progress on the mechanism of orexin in pain regulation in different brain regions |
| topic | orexins orexin a pain regulation orexin receptors acute pain |
| url | https://doi.org/10.1515/biol-2021-0001 |
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