INFLAMMATORY INFILTRATION IN THE GASTRIC MUCOSA OF PATIENTS WITH EPSTEIN-BARR VIRUS-ASSOCIATED GASTRIC DYSPLASIA AND CANCER
Characteristics of inflammatory infiltrate in the gastric mucosa of patients with gastric dysplasia (n=56) and gastric cancer (n=50) with different levels of humoral immune response to Epstein-Barr virus (EBV) and EBV viral load were studied. In patients with dysplasia of the gastric mucosa, the inc...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2016-02-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/284 |
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| author | М. V. Vusik R. I. Pleshko Т. V. Avdeenko О. V. Cheremisina L. N. Urazova N. V. Yunusova |
| author_facet | М. V. Vusik R. I. Pleshko Т. V. Avdeenko О. V. Cheremisina L. N. Urazova N. V. Yunusova |
| author_sort | М. V. Vusik |
| collection | DOAJ |
| description | Characteristics of inflammatory infiltrate in the gastric mucosa of patients with gastric dysplasia (n=56) and gastric cancer (n=50) with different levels of humoral immune response to Epstein-Barr virus (EBV) and EBV viral load were studied. In patients with dysplasia of the gastric mucosa, the increase in antibody titers to VCA IgG leaded to a significant decrease in the level of lymphocytes, neutrophils and macrophages and an increase in the number of eosinophils and plasma cells. When the levels of IgA to viral capsid antigen (VCA) and IgG to EBV early antigens (EA) were increased, the number of neutrophils in the composition of the cellular infiltrate was significantly decreased. In gastric cancer patients with different levels of humoral immune response to EBV, the number of plasma cells and eosinophils in the inflammatory infiltrate of the tumor was decreased when increasing the titers of IgG to VCA and IgA to VCA. When VCA/IgA titer was high, the number of neutrophils in a tumor was decreased and the proportion of macrophages was slightly increased. The data obtained can serve as additional criteria for indentifying markers for viral infection of the gastric mucosa. |
| first_indexed | 2024-04-10T01:54:16Z |
| format | Article |
| id | doaj.art-6674120b1e9b42b48a726e58422edab8 |
| institution | Directory Open Access Journal |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| last_indexed | 2025-03-14T10:09:40Z |
| publishDate | 2016-02-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj.art-6674120b1e9b42b48a726e58422edab82025-03-02T11:16:06ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682016-02-01063339284INFLAMMATORY INFILTRATION IN THE GASTRIC MUCOSA OF PATIENTS WITH EPSTEIN-BARR VIRUS-ASSOCIATED GASTRIC DYSPLASIA AND CANCERМ. V. Vusik0R. I. Pleshko1Т. V. Avdeenko2О. V. Cheremisina3L. N. Urazova4N. V. Yunusova5Tomsk Cancer Research InstituteSiberian State Medical University, TomskTomsk Cancer Research InstituteTomsk Cancer Research InstituteTomsk Cancer Research InstituteTomsk Cancer Research Institute Siberian State Medical University, TomskCharacteristics of inflammatory infiltrate in the gastric mucosa of patients with gastric dysplasia (n=56) and gastric cancer (n=50) with different levels of humoral immune response to Epstein-Barr virus (EBV) and EBV viral load were studied. In patients with dysplasia of the gastric mucosa, the increase in antibody titers to VCA IgG leaded to a significant decrease in the level of lymphocytes, neutrophils and macrophages and an increase in the number of eosinophils and plasma cells. When the levels of IgA to viral capsid antigen (VCA) and IgG to EBV early antigens (EA) were increased, the number of neutrophils in the composition of the cellular infiltrate was significantly decreased. In gastric cancer patients with different levels of humoral immune response to EBV, the number of plasma cells and eosinophils in the inflammatory infiltrate of the tumor was decreased when increasing the titers of IgG to VCA and IgA to VCA. When VCA/IgA titer was high, the number of neutrophils in a tumor was decreased and the proportion of macrophages was slightly increased. The data obtained can serve as additional criteria for indentifying markers for viral infection of the gastric mucosa.https://www.siboncoj.ru/jour/article/view/284composition of the cellular infiltrate of the gastric mucosaepstein-barr virusgastric dysplasiagastric cancer |
| spellingShingle | М. V. Vusik R. I. Pleshko Т. V. Avdeenko О. V. Cheremisina L. N. Urazova N. V. Yunusova INFLAMMATORY INFILTRATION IN THE GASTRIC MUCOSA OF PATIENTS WITH EPSTEIN-BARR VIRUS-ASSOCIATED GASTRIC DYSPLASIA AND CANCER Сибирский онкологический журнал composition of the cellular infiltrate of the gastric mucosa epstein-barr virus gastric dysplasia gastric cancer |
| title | INFLAMMATORY INFILTRATION IN THE GASTRIC MUCOSA OF PATIENTS WITH EPSTEIN-BARR VIRUS-ASSOCIATED GASTRIC DYSPLASIA AND CANCER |
| title_full | INFLAMMATORY INFILTRATION IN THE GASTRIC MUCOSA OF PATIENTS WITH EPSTEIN-BARR VIRUS-ASSOCIATED GASTRIC DYSPLASIA AND CANCER |
| title_fullStr | INFLAMMATORY INFILTRATION IN THE GASTRIC MUCOSA OF PATIENTS WITH EPSTEIN-BARR VIRUS-ASSOCIATED GASTRIC DYSPLASIA AND CANCER |
| title_full_unstemmed | INFLAMMATORY INFILTRATION IN THE GASTRIC MUCOSA OF PATIENTS WITH EPSTEIN-BARR VIRUS-ASSOCIATED GASTRIC DYSPLASIA AND CANCER |
| title_short | INFLAMMATORY INFILTRATION IN THE GASTRIC MUCOSA OF PATIENTS WITH EPSTEIN-BARR VIRUS-ASSOCIATED GASTRIC DYSPLASIA AND CANCER |
| title_sort | inflammatory infiltration in the gastric mucosa of patients with epstein barr virus associated gastric dysplasia and cancer |
| topic | composition of the cellular infiltrate of the gastric mucosa epstein-barr virus gastric dysplasia gastric cancer |
| url | https://www.siboncoj.ru/jour/article/view/284 |
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