HUMAN PAPILLOMAVIRUS INFECTION AND HEAD AND NECK CANCER PROGRESSION
Abstract. The aim of present study was to evaluate the influence of HPV infection on lymphogenic metastasis and survival of patients with head and neck squamous cell carcinoma. DNA was isolated from tumor tissue and tumor-adjacent normal epithelium of 64 patients with head and neck tumors of differe...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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Sankt-Peterburg : NIIÈM imeni Pastera
2014-07-01
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| Series: | Инфекция и иммунитет |
| Subjects: | |
| Online Access: | https://www.iimmun.ru/iimm/article/view/167 |
| _version_ | 1797967925511979008 |
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| author | V. A. Bychkov L. N. Urazova E. G. Nikitina O. V. Cheremisina S. Y. Chizhevskaya |
| author_facet | V. A. Bychkov L. N. Urazova E. G. Nikitina O. V. Cheremisina S. Y. Chizhevskaya |
| author_sort | V. A. Bychkov |
| collection | DOAJ |
| description | Abstract. The aim of present study was to evaluate the influence of HPV infection on lymphogenic metastasis and survival of patients with head and neck squamous cell carcinoma. DNA was isolated from tumor tissue and tumor-adjacent normal epithelium of 64 patients with head and neck tumors of different localization. Detection of 12 HPV genotypes was carried out by the PCR using AmpliSens diagnostic kits (Russia). The association between HPV infection and clinical-pathological parameters of the patients was assessed. HPV was detected in tumor tissue and in the surrounding normal tissue in 22% of patients. The most common HPV genotypes were 16 and 51. No association of HPV infection with sex, age, location, TNM stage and differentiation grade was found. The Kaplan Meier method showed a tendency towards the improvement of the overall and recurrence-free survival of HPV-positive patients with head and neck cancer (p = 0.09 and p = 0.12 respectively). The multivariate survival analysis using Cox’s regression model showed that the patient’s age and the presence of lymph node metastases (p = 0.002) significantly influence on patient survival (p = 0.014 and p = 0.002 respectively). |
| first_indexed | 2024-04-11T02:37:46Z |
| format | Article |
| id | doaj.art-6675bfa54fc84cca973c466865a8a328 |
| institution | Directory Open Access Journal |
| issn | 2220-7619 2313-7398 |
| language | Russian |
| last_indexed | 2024-04-11T02:37:46Z |
| publishDate | 2014-07-01 |
| publisher | Sankt-Peterburg : NIIÈM imeni Pastera |
| record_format | Article |
| series | Инфекция и иммунитет |
| spelling | doaj.art-6675bfa54fc84cca973c466865a8a3282023-01-02T19:35:51ZrusSankt-Peterburg : NIIÈM imeni PasteraИнфекция и иммунитет2220-76192313-73982014-07-014216216610.15789/2220-7619-2014-2-162-166167HUMAN PAPILLOMAVIRUS INFECTION AND HEAD AND NECK CANCER PROGRESSIONV. A. Bychkov0L. N. Urazova1E. G. Nikitina2O. V. Cheremisina3S. Y. Chizhevskaya4Tosmk cancer research institute of the Russian Academy of Medical ScienceTosmk cancer research institute of the Russian Academy of Medical ScienceTosmk cancer research institute of the Russian Academy of Medical ScienceTosmk cancer research institute of the Russian Academy of Medical ScienceTosmk cancer research institute of the Russian Academy of Medical ScienceAbstract. The aim of present study was to evaluate the influence of HPV infection on lymphogenic metastasis and survival of patients with head and neck squamous cell carcinoma. DNA was isolated from tumor tissue and tumor-adjacent normal epithelium of 64 patients with head and neck tumors of different localization. Detection of 12 HPV genotypes was carried out by the PCR using AmpliSens diagnostic kits (Russia). The association between HPV infection and clinical-pathological parameters of the patients was assessed. HPV was detected in tumor tissue and in the surrounding normal tissue in 22% of patients. The most common HPV genotypes were 16 and 51. No association of HPV infection with sex, age, location, TNM stage and differentiation grade was found. The Kaplan Meier method showed a tendency towards the improvement of the overall and recurrence-free survival of HPV-positive patients with head and neck cancer (p = 0.09 and p = 0.12 respectively). The multivariate survival analysis using Cox’s regression model showed that the patient’s age and the presence of lymph node metastases (p = 0.002) significantly influence on patient survival (p = 0.014 and p = 0.002 respectively).https://www.iimmun.ru/iimm/article/view/167human papillomavirustumor progressionsurviving, metastasis |
| spellingShingle | V. A. Bychkov L. N. Urazova E. G. Nikitina O. V. Cheremisina S. Y. Chizhevskaya HUMAN PAPILLOMAVIRUS INFECTION AND HEAD AND NECK CANCER PROGRESSION Инфекция и иммунитет human papillomavirus tumor progression surviving, metastasis |
| title | HUMAN PAPILLOMAVIRUS INFECTION AND HEAD AND NECK CANCER PROGRESSION |
| title_full | HUMAN PAPILLOMAVIRUS INFECTION AND HEAD AND NECK CANCER PROGRESSION |
| title_fullStr | HUMAN PAPILLOMAVIRUS INFECTION AND HEAD AND NECK CANCER PROGRESSION |
| title_full_unstemmed | HUMAN PAPILLOMAVIRUS INFECTION AND HEAD AND NECK CANCER PROGRESSION |
| title_short | HUMAN PAPILLOMAVIRUS INFECTION AND HEAD AND NECK CANCER PROGRESSION |
| title_sort | human papillomavirus infection and head and neck cancer progression |
| topic | human papillomavirus tumor progression surviving, metastasis |
| url | https://www.iimmun.ru/iimm/article/view/167 |
| work_keys_str_mv | AT vabychkov humanpapillomavirusinfectionandheadandneckcancerprogression AT lnurazova humanpapillomavirusinfectionandheadandneckcancerprogression AT egnikitina humanpapillomavirusinfectionandheadandneckcancerprogression AT ovcheremisina humanpapillomavirusinfectionandheadandneckcancerprogression AT sychizhevskaya humanpapillomavirusinfectionandheadandneckcancerprogression |