An alternative pathway for alphavirus entry
<p>Abstract</p> <p>The study of alphavirus entry has been complicated by an inability to clearly identify a receptor and by experiments which only tangentially and indirectly examine the process, producing results that are difficult to interpret. The mechanism of entry has been wid...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-06-01
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| Series: | Virology Journal |
| Online Access: | http://www.virologyj.com/content/8/1/304 |
| _version_ | 1819031798783410176 |
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| author | Brown Dennis T Hernandez Raquel Kononchik Joseph P |
| author_facet | Brown Dennis T Hernandez Raquel Kononchik Joseph P |
| author_sort | Brown Dennis T |
| collection | DOAJ |
| description | <p>Abstract</p> <p>The study of alphavirus entry has been complicated by an inability to clearly identify a receptor and by experiments which only tangentially and indirectly examine the process, producing results that are difficult to interpret. The mechanism of entry has been widely accepted to be by endocytosis followed by acidification of the endosome resulting in virus membrane-endosome membrane fusion. This mechanism has come under scrutiny as better purification protocols and improved methods of analysis have been brought to the study. Results have been obtained that suggest alphaviruses infect cells directly at the plasma membrane without the involvement of endocytosis, exposure to acid pH, or membrane fusion. In this review we compare the data which support the two models and make the case for an alternative pathway of entry by alphaviruses.</p> |
| first_indexed | 2024-12-21T06:51:47Z |
| format | Article |
| id | doaj.art-667739848c1c43658317a90450e858ca |
| institution | Directory Open Access Journal |
| issn | 1743-422X |
| language | English |
| last_indexed | 2024-12-21T06:51:47Z |
| publishDate | 2011-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj.art-667739848c1c43658317a90450e858ca2022-12-21T19:12:27ZengBMCVirology Journal1743-422X2011-06-018130410.1186/1743-422X-8-304An alternative pathway for alphavirus entryBrown Dennis THernandez RaquelKononchik Joseph P<p>Abstract</p> <p>The study of alphavirus entry has been complicated by an inability to clearly identify a receptor and by experiments which only tangentially and indirectly examine the process, producing results that are difficult to interpret. The mechanism of entry has been widely accepted to be by endocytosis followed by acidification of the endosome resulting in virus membrane-endosome membrane fusion. This mechanism has come under scrutiny as better purification protocols and improved methods of analysis have been brought to the study. Results have been obtained that suggest alphaviruses infect cells directly at the plasma membrane without the involvement of endocytosis, exposure to acid pH, or membrane fusion. In this review we compare the data which support the two models and make the case for an alternative pathway of entry by alphaviruses.</p>http://www.virologyj.com/content/8/1/304 |
| spellingShingle | Brown Dennis T Hernandez Raquel Kononchik Joseph P An alternative pathway for alphavirus entry Virology Journal |
| title | An alternative pathway for alphavirus entry |
| title_full | An alternative pathway for alphavirus entry |
| title_fullStr | An alternative pathway for alphavirus entry |
| title_full_unstemmed | An alternative pathway for alphavirus entry |
| title_short | An alternative pathway for alphavirus entry |
| title_sort | alternative pathway for alphavirus entry |
| url | http://www.virologyj.com/content/8/1/304 |
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