Sudden Vision Loss Due to Optic Neuritis—An Uncommon Presentation of Neurosarcoidosis
Sarcoidosis is a systemic, granulomatous disease of unknown etiology, most often manifested by mediastinal and hilar lymph node enlargement and parenchymal nodules in the lungs. However, it may involve any other organ. Neuro-sarcoidosis, a condition that affects up to 20% of sarcoidosis patients, ca...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/15/2579 |
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| author | Katarzyna Zimna Monika Szturmowicz Małgorzata Sobiecka Katarzyna Błasińska Małgorzata Bartosiewicz Witold Z. Tomkowski |
| author_facet | Katarzyna Zimna Monika Szturmowicz Małgorzata Sobiecka Katarzyna Błasińska Małgorzata Bartosiewicz Witold Z. Tomkowski |
| author_sort | Katarzyna Zimna |
| collection | DOAJ |
| description | Sarcoidosis is a systemic, granulomatous disease of unknown etiology, most often manifested by mediastinal and hilar lymph node enlargement and parenchymal nodules in the lungs. However, it may involve any other organ. Neuro-sarcoidosis, a condition that affects up to 20% of sarcoidosis patients, can be found in any part of the central or peripheral nervous system and has important ophthalmic and neuro-ophthalmic manifestations. We present two patients with sudden vision loss due to neurosarcoidosis. In both cases, biopsy of the mediastinal lymph node showed non-caseating granulomas consistent with sarcoidosis. Treatment involved high doses of methylprednisolone intravenously, followed by topical dexamethasone eye drops in the first case and a systemic steroid treatment in the second, resulting in symptom relief. Those two cases demonstrate that sarcoidosis should be considered as a differential diagnosis in cases of optic neuritis. |
| first_indexed | 2024-03-11T00:29:24Z |
| format | Article |
| id | doaj.art-6677db807ef540fbbcf9b83708a231d4 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T00:29:24Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-6677db807ef540fbbcf9b83708a231d42023-11-18T22:47:24ZengMDPI AGDiagnostics2075-44182023-08-011315257910.3390/diagnostics13152579Sudden Vision Loss Due to Optic Neuritis—An Uncommon Presentation of NeurosarcoidosisKatarzyna Zimna0Monika Szturmowicz1Małgorzata Sobiecka2Katarzyna Błasińska3Małgorzata Bartosiewicz4Witold Z. Tomkowski51st Department of Lung Diseases, National Tuberculosis and Lung Diseases Research Institute, 01-138 Warsaw, Poland1st Department of Lung Diseases, National Tuberculosis and Lung Diseases Research Institute, 01-138 Warsaw, Poland1st Department of Lung Diseases, National Tuberculosis and Lung Diseases Research Institute, 01-138 Warsaw, PolandDepartment of Radiology, National Tuberculosis and Lung Diseases Research Institute, 01-138 Warsaw, Poland1st Department of Lung Diseases, National Tuberculosis and Lung Diseases Research Institute, 01-138 Warsaw, Poland1st Department of Lung Diseases, National Tuberculosis and Lung Diseases Research Institute, 01-138 Warsaw, PolandSarcoidosis is a systemic, granulomatous disease of unknown etiology, most often manifested by mediastinal and hilar lymph node enlargement and parenchymal nodules in the lungs. However, it may involve any other organ. Neuro-sarcoidosis, a condition that affects up to 20% of sarcoidosis patients, can be found in any part of the central or peripheral nervous system and has important ophthalmic and neuro-ophthalmic manifestations. We present two patients with sudden vision loss due to neurosarcoidosis. In both cases, biopsy of the mediastinal lymph node showed non-caseating granulomas consistent with sarcoidosis. Treatment involved high doses of methylprednisolone intravenously, followed by topical dexamethasone eye drops in the first case and a systemic steroid treatment in the second, resulting in symptom relief. Those two cases demonstrate that sarcoidosis should be considered as a differential diagnosis in cases of optic neuritis.https://www.mdpi.com/2075-4418/13/15/2579sarcoidosisoptic nerve neuritisneuro-sarcoidosis |
| spellingShingle | Katarzyna Zimna Monika Szturmowicz Małgorzata Sobiecka Katarzyna Błasińska Małgorzata Bartosiewicz Witold Z. Tomkowski Sudden Vision Loss Due to Optic Neuritis—An Uncommon Presentation of Neurosarcoidosis Diagnostics sarcoidosis optic nerve neuritis neuro-sarcoidosis |
| title | Sudden Vision Loss Due to Optic Neuritis—An Uncommon Presentation of Neurosarcoidosis |
| title_full | Sudden Vision Loss Due to Optic Neuritis—An Uncommon Presentation of Neurosarcoidosis |
| title_fullStr | Sudden Vision Loss Due to Optic Neuritis—An Uncommon Presentation of Neurosarcoidosis |
| title_full_unstemmed | Sudden Vision Loss Due to Optic Neuritis—An Uncommon Presentation of Neurosarcoidosis |
| title_short | Sudden Vision Loss Due to Optic Neuritis—An Uncommon Presentation of Neurosarcoidosis |
| title_sort | sudden vision loss due to optic neuritis an uncommon presentation of neurosarcoidosis |
| topic | sarcoidosis optic nerve neuritis neuro-sarcoidosis |
| url | https://www.mdpi.com/2075-4418/13/15/2579 |
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