Inhibition of histone deacetylase 6 destabilizes ERK phosphorylation and suppresses cancer proliferation via modulation of the tubulin acetylation-GRP78 interaction

Inhibition of histone deacetylase 6 destabilizes ERK phosphorylation and suppresses cancer proliferation via modulation of the tubulin acetylation-GRP78 interaction

Abstract Background The leading cause of cancer-related mortality worldwide is lung cancer, and its clinical outcome and prognosis are still unsatisfactory. The understanding of potential molecular targets is necessary for clinical implications in precision diagnostic and/or therapeutic purposes. Hi...

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Bibliographic Details
Main Authors: Onsurang Wattanathamsan, Naphat Chantaravisoot, Piriya Wongkongkathep, Sakkarin Kungsukool, Paninee Chetprayoon, Pithi Chanvorachote, Chanida Vinayanuwattikun, Varisa Pongrakhananon
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Journal of Biomedical Science
Subjects:
Extracellular signal-regulated kinase (ERK)
Glucose-regulated protein 78 (GRP78)
Histone deacetylase 6 (HDAC6)
Lung cancer
Tubulin acetylation
Online Access:https://doi.org/10.1186/s12929-023-00898-3

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