Wogonin Induces Apoptosis and Reverses Sunitinib Resistance of Renal Cell Carcinoma Cells via Inhibiting CDK4-RB Pathway

Wogonin Induces Apoptosis and Reverses Sunitinib Resistance of Renal Cell Carcinoma Cells via Inhibiting CDK4-RB Pathway

Wogonin, an active component derived from Scutellaria baicalensis, has shown anti-tumor activities in several malignancies. However, the roles of wogonin in RCC cells remain elusive. Here, we explored the effects of wogonin on RCC cells and the underlying mechanisms. We found that wogonin showed sig...

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Bibliographic Details
Main Authors: Yong Wang, Shouzhen Chen, Shuna Sun, Guangyi Liu, Lipeng Chen, Yangyang Xia, Jianfeng Cui, Wenfu Wang, Xuewen Jiang, Lei Zhang, Yaofeng Zhu, Yongxin Zou, Benkang Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Pharmacology
Subjects:
wogonin
RCC
apoptosis
CDK4-RB
sunitinib
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01152/full

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