Sustained response to erythropoietin for anemia in NK-cell large granular lymphocytosis: A brief case report
Large granular lymphocytic leukemia (LGL) is a rare lymphoproliferative disorder that involves the T-cell lineage in around 85% of cases and NK-cell lineage in 15%. Most patients require treatment at some point of their disease trajectory to address clinical symptomatology largely pertaining to cyto...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Leukemia Research Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213048922000048 |
| _version_ | 1828473943531454464 |
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| author | Tendai Kwaramba Brian Lewis Bruce Burks Bernardo Ruiz Swaminathan P. Iyer Firas Safa |
| author_facet | Tendai Kwaramba Brian Lewis Bruce Burks Bernardo Ruiz Swaminathan P. Iyer Firas Safa |
| author_sort | Tendai Kwaramba |
| collection | DOAJ |
| description | Large granular lymphocytic leukemia (LGL) is a rare lymphoproliferative disorder that involves the T-cell lineage in around 85% of cases and NK-cell lineage in 15%. Most patients require treatment at some point of their disease trajectory to address clinical symptomatology largely pertaining to cytopenia. While immunosuppression represents the backbone of LGL therapy, there is no consensus on the best next line following failure of immunosuppression. Here we present a case of LGL-associated cytopenia in a 73-year-old male refractory to immunosuppression, treated with adjunct erythropoietin alpha (EPO) with a marked response. Our case suggests that EPO therapy may provide therapeutic benefit in refractory LGL cases when used in conjunction with immunosuppressive therapy. |
| first_indexed | 2024-12-11T05:52:50Z |
| format | Article |
| id | doaj.art-667c539f98c94bc3a31bbc106d1b538e |
| institution | Directory Open Access Journal |
| issn | 2213-0489 |
| language | English |
| last_indexed | 2024-12-11T05:52:50Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Leukemia Research Reports |
| spelling | doaj.art-667c539f98c94bc3a31bbc106d1b538e2022-12-22T01:18:46ZengElsevierLeukemia Research Reports2213-04892022-01-0117100292Sustained response to erythropoietin for anemia in NK-cell large granular lymphocytosis: A brief case reportTendai Kwaramba0Brian Lewis1Bruce Burks2Bernardo Ruiz3Swaminathan P. Iyer4Firas Safa5Department of Medicine, Tulane University, New Orleans, LA United States; Corresponding author at: Department of Medicine, Tulane University, New Orleans LA 131 S Robertson Building, New Orleans, LA 70112 United StatesSection of Hematology and Medical Oncology, Department of Medicine, Tulane University, New Orleans, LA United StatesDepartment of Pathology, San Diego VA Medical Center, San Diego, CA United StatesDepartment of Pathology, New Orleans VA Medical Center, New Orleans, LA United StatesDepartment of Lymphoma/Myeloma, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX United StatesSection of Hematology and Medical Oncology, Department of Medicine, Tulane University, New Orleans, LA United States; Corresponding author at: Section of Hematology and Medical Oncology, Department of Medicine, Tulane University, New Orleans, LA 1430 Tulane Ave, Mail Code # 8078, New Orleans, LA 70112 United StatesLarge granular lymphocytic leukemia (LGL) is a rare lymphoproliferative disorder that involves the T-cell lineage in around 85% of cases and NK-cell lineage in 15%. Most patients require treatment at some point of their disease trajectory to address clinical symptomatology largely pertaining to cytopenia. While immunosuppression represents the backbone of LGL therapy, there is no consensus on the best next line following failure of immunosuppression. Here we present a case of LGL-associated cytopenia in a 73-year-old male refractory to immunosuppression, treated with adjunct erythropoietin alpha (EPO) with a marked response. Our case suggests that EPO therapy may provide therapeutic benefit in refractory LGL cases when used in conjunction with immunosuppressive therapy.http://www.sciencedirect.com/science/article/pii/S2213048922000048EPOCLPD-NKsAnemia |
| spellingShingle | Tendai Kwaramba Brian Lewis Bruce Burks Bernardo Ruiz Swaminathan P. Iyer Firas Safa Sustained response to erythropoietin for anemia in NK-cell large granular lymphocytosis: A brief case report Leukemia Research Reports EPO CLPD-NKs Anemia |
| title | Sustained response to erythropoietin for anemia in NK-cell large granular lymphocytosis: A brief case report |
| title_full | Sustained response to erythropoietin for anemia in NK-cell large granular lymphocytosis: A brief case report |
| title_fullStr | Sustained response to erythropoietin for anemia in NK-cell large granular lymphocytosis: A brief case report |
| title_full_unstemmed | Sustained response to erythropoietin for anemia in NK-cell large granular lymphocytosis: A brief case report |
| title_short | Sustained response to erythropoietin for anemia in NK-cell large granular lymphocytosis: A brief case report |
| title_sort | sustained response to erythropoietin for anemia in nk cell large granular lymphocytosis a brief case report |
| topic | EPO CLPD-NKs Anemia |
| url | http://www.sciencedirect.com/science/article/pii/S2213048922000048 |
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