The Salmonella T3SS1 effector IpaJ is regulated by ItrA and inhibits the MAPK signaling pathway

The Salmonella T3SS1 effector IpaJ is regulated by ItrA and inhibits the MAPK signaling pathway

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Invasion plasmid antigen J (IpaJ) is a protein with cysteine protease activity that is present in Salmonella and Shigella species. Salmonella enterica serovar Pullorum uses IpaJ to inhibit the NF-κB pathway and the subsequent inflammatory response, resulting in bacterial survival in host macrophages...

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Bibliographic Details
Main Authors: Chao Yin, Jiaojie Gu, Dan Gu, Zhenyu Wang, Ruoyun Ji, Xinan Jiao, Qiuchun Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-12-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728880/?tool=EBI

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