Enhanced proliferation of oligodendrocyte progenitor cells following retrovirus mediated Achaete-scute complex-like 1 overexpression in the postnatal cerebral cortex in vivo

Enhanced proliferation of oligodendrocyte progenitor cells following retrovirus mediated Achaete-scute complex-like 1 overexpression in the postnatal cerebral cortex in vivo

The proneural transcription factor Achaete-scute complex-like 1 (Ascl1) is a major regulator of neural fate decisions, implicated both in neurogenesis and oligodendrogliogenesis. Focusing on its neurogenic activity, Ascl1 has been widely used to reprogram non-neuronal cells into induced neurons. In...

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Bibliographic Details
Main Authors: Chiara Galante, Nicolás Marichal, Franciele Franco Scarante, Litsa Maria Ghayad, Youran Shi, Carol Schuurmans, Benedikt Berninger, Sophie Péron
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Neuroscience
Subjects:
astrocyte
gliogenesis
lineage reprogramming
neurogenesis
proliferation
proneural
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.919462/full

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