Demographics and prognosis of patients with pyogenic liver abscess due to Klebsiella pneumonia or other species
Background: Pyogenic liver abscess (PLA) is a potentially life-threatening intra-abdominal infection. We compared the clinical features, treatments, and prognoses of patients who had Klebsiella pneumonia pyogenic liver abscess (KPPLA) and non-Klebsiella pneumonia pyogenic liver abscess (non-KPPLA)....
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S240584402405494X |
| _version_ | 1797210036163837952 |
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| author | Qiaomai Xu Changhong Liu Zhengjie Wu Shumeng Zhang Zhuoling Chen Yu Shi Silan Gu |
| author_facet | Qiaomai Xu Changhong Liu Zhengjie Wu Shumeng Zhang Zhuoling Chen Yu Shi Silan Gu |
| author_sort | Qiaomai Xu |
| collection | DOAJ |
| description | Background: Pyogenic liver abscess (PLA) is a potentially life-threatening intra-abdominal infection. We compared the clinical features, treatments, and prognoses of patients who had Klebsiella pneumonia pyogenic liver abscess (KPPLA) and non-Klebsiella pneumonia pyogenic liver abscess (non-KPPLA). Methods: A retrospective analysis was used to compare the medical records of KPPLA and non-KPPLA patients with positive pus cultures at a single hospital in China from January 2017 to December 2019. Results: We examined 279 patients with definitively established PLA, 207 (74.2 %) with KPPLA, and 72 with non-KPPLA. The non-KPPLA group had a higher Charlson comorbidity index, longer hospital stay, longer duration of fever, and greater hospital costs. Multivariate analysis showed that alcohol intake (OR: 2.44, P = 0.048), cancer (OR: 4.80, P = 0.001), ICU admission (OR: 10.61, P = 0.026), resolution of fever OR: 1.04, P = 0.020), and a positive blood culture (OR: 2.87, P = 0.029) were independent predictors of primary treatment failure. Percutaneous needle aspiration (PNA) and pigtail catheter drainage (PCD) provided satisfactory outcomes, but PNA led to shorter hospital stays and reduced costs, especially in KPPLA patients whose abscesses were smaller than 10 cm. Conclusion: KPPLA and non-KPPLA patients had some differences in comorbidities and treatment strategies, and non-KPPLA patients had a significantly worse prognosis. |
| first_indexed | 2024-04-24T10:04:12Z |
| format | Article |
| id | doaj.art-66817114c73846e4b4e1a4b690054c06 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T10:04:12Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-66817114c73846e4b4e1a4b690054c062024-04-13T04:21:35ZengElsevierHeliyon2405-84402024-04-01108e29463Demographics and prognosis of patients with pyogenic liver abscess due to Klebsiella pneumonia or other speciesQiaomai Xu0Changhong Liu1Zhengjie Wu2Shumeng Zhang3Zhuoling Chen4Yu Shi5Silan Gu6State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Hepatology, The Fifth People's Hospital of Ganzhou, Ganzhou Institute of Hepatology, Ganzhou, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Respiratory Disease, Thoracic Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaHangzhou Medical College, Hangzhou, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Corresponding author.Background: Pyogenic liver abscess (PLA) is a potentially life-threatening intra-abdominal infection. We compared the clinical features, treatments, and prognoses of patients who had Klebsiella pneumonia pyogenic liver abscess (KPPLA) and non-Klebsiella pneumonia pyogenic liver abscess (non-KPPLA). Methods: A retrospective analysis was used to compare the medical records of KPPLA and non-KPPLA patients with positive pus cultures at a single hospital in China from January 2017 to December 2019. Results: We examined 279 patients with definitively established PLA, 207 (74.2 %) with KPPLA, and 72 with non-KPPLA. The non-KPPLA group had a higher Charlson comorbidity index, longer hospital stay, longer duration of fever, and greater hospital costs. Multivariate analysis showed that alcohol intake (OR: 2.44, P = 0.048), cancer (OR: 4.80, P = 0.001), ICU admission (OR: 10.61, P = 0.026), resolution of fever OR: 1.04, P = 0.020), and a positive blood culture (OR: 2.87, P = 0.029) were independent predictors of primary treatment failure. Percutaneous needle aspiration (PNA) and pigtail catheter drainage (PCD) provided satisfactory outcomes, but PNA led to shorter hospital stays and reduced costs, especially in KPPLA patients whose abscesses were smaller than 10 cm. Conclusion: KPPLA and non-KPPLA patients had some differences in comorbidities and treatment strategies, and non-KPPLA patients had a significantly worse prognosis.http://www.sciencedirect.com/science/article/pii/S240584402405494XPyogenic liver abscessKlebsiella pneumoniaPercutaneous needle aspirationPigtail catheter drainageTreatment failure |
| spellingShingle | Qiaomai Xu Changhong Liu Zhengjie Wu Shumeng Zhang Zhuoling Chen Yu Shi Silan Gu Demographics and prognosis of patients with pyogenic liver abscess due to Klebsiella pneumonia or other species Heliyon Pyogenic liver abscess Klebsiella pneumonia Percutaneous needle aspiration Pigtail catheter drainage Treatment failure |
| title | Demographics and prognosis of patients with pyogenic liver abscess due to Klebsiella pneumonia or other species |
| title_full | Demographics and prognosis of patients with pyogenic liver abscess due to Klebsiella pneumonia or other species |
| title_fullStr | Demographics and prognosis of patients with pyogenic liver abscess due to Klebsiella pneumonia or other species |
| title_full_unstemmed | Demographics and prognosis of patients with pyogenic liver abscess due to Klebsiella pneumonia or other species |
| title_short | Demographics and prognosis of patients with pyogenic liver abscess due to Klebsiella pneumonia or other species |
| title_sort | demographics and prognosis of patients with pyogenic liver abscess due to klebsiella pneumonia or other species |
| topic | Pyogenic liver abscess Klebsiella pneumonia Percutaneous needle aspiration Pigtail catheter drainage Treatment failure |
| url | http://www.sciencedirect.com/science/article/pii/S240584402405494X |
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