EPHX2 Inhibits Colon Cancer Progression by Promoting Fatty Acid Degradation
Tumor cells use metabolic reprogramming to keep up with the need for bioenergy, biosynthesis, and oxidation balance needed for rapid tumor division. This phenomenon is considered a marker of tumors, including colon cancer (CRC). As an important pathway of cellular energy metabolism, fatty acid metab...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.870721/full |
| _version_ | 1811260621668220928 |
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| author | Yiran Zhou Yiran Zhou Xiao Li Xiao Li Aoran Guan Aoran Guan Haodong Zhou Haodong Zhou Yankun Zhu Yankun Zhu Ruotian Wang Ruotian Wang Ruhong Li Ruhong Li |
| author_facet | Yiran Zhou Yiran Zhou Xiao Li Xiao Li Aoran Guan Aoran Guan Haodong Zhou Haodong Zhou Yankun Zhu Yankun Zhu Ruotian Wang Ruotian Wang Ruhong Li Ruhong Li |
| author_sort | Yiran Zhou |
| collection | DOAJ |
| description | Tumor cells use metabolic reprogramming to keep up with the need for bioenergy, biosynthesis, and oxidation balance needed for rapid tumor division. This phenomenon is considered a marker of tumors, including colon cancer (CRC). As an important pathway of cellular energy metabolism, fatty acid metabolism plays an important role in cellular energy supply and oxidation balance, but presently, our understanding of the exact role of fatty acid metabolism in CRC is limited. Currently, no lipid metabolism therapy is available for the treatment of CRC. The establishment of a lipidmetabolism model regulated by oncogenes/tumor suppressor genes and associated with the clinical characteristics of CRC is necessary to further understand the mechanism of fatty acid metabolism in CRC. In this study, through multi-data combined with bioinformatic analysis and basic experiments, we introduced a tumor suppressor gene, EPHX2, which is rarely reported in CRC, and confirmed that its inhibitory effect on CRC is related to fatty acid degradation. |
| first_indexed | 2024-04-12T18:50:07Z |
| format | Article |
| id | doaj.art-6685f4f4ad7c42389a26ab753af7d21b |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T18:50:07Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-6685f4f4ad7c42389a26ab753af7d21b2022-12-22T03:20:30ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-03-011210.3389/fonc.2022.870721870721EPHX2 Inhibits Colon Cancer Progression by Promoting Fatty Acid DegradationYiran Zhou0Yiran Zhou1Xiao Li2Xiao Li3Aoran Guan4Aoran Guan5Haodong Zhou6Haodong Zhou7Yankun Zhu8Yankun Zhu9Ruotian Wang10Ruotian Wang11Ruhong Li12Ruhong Li13Department of General Surgery, Yan’an Hospital Affiliated to Kunming Medical University, Yan’an Hospital of Kunming City, Kunming, ChinaKey Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Kunming, ChinaDepartment of General Surgery, Yan’an Hospital Affiliated to Kunming Medical University, Yan’an Hospital of Kunming City, Kunming, ChinaKey Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Kunming, ChinaDepartment of General Surgery, Yan’an Hospital Affiliated to Kunming Medical University, Yan’an Hospital of Kunming City, Kunming, ChinaKey Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Kunming, ChinaDepartment of General Surgery, Yan’an Hospital Affiliated to Kunming Medical University, Yan’an Hospital of Kunming City, Kunming, ChinaKey Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Kunming, ChinaDepartment of General Surgery, Yan’an Hospital Affiliated to Kunming Medical University, Yan’an Hospital of Kunming City, Kunming, ChinaKey Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Kunming, ChinaDepartment of General Surgery, Yan’an Hospital Affiliated to Kunming Medical University, Yan’an Hospital of Kunming City, Kunming, ChinaKey Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Kunming, ChinaDepartment of General Surgery, Yan’an Hospital Affiliated to Kunming Medical University, Yan’an Hospital of Kunming City, Kunming, ChinaKey Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Kunming, ChinaTumor cells use metabolic reprogramming to keep up with the need for bioenergy, biosynthesis, and oxidation balance needed for rapid tumor division. This phenomenon is considered a marker of tumors, including colon cancer (CRC). As an important pathway of cellular energy metabolism, fatty acid metabolism plays an important role in cellular energy supply and oxidation balance, but presently, our understanding of the exact role of fatty acid metabolism in CRC is limited. Currently, no lipid metabolism therapy is available for the treatment of CRC. The establishment of a lipidmetabolism model regulated by oncogenes/tumor suppressor genes and associated with the clinical characteristics of CRC is necessary to further understand the mechanism of fatty acid metabolism in CRC. In this study, through multi-data combined with bioinformatic analysis and basic experiments, we introduced a tumor suppressor gene, EPHX2, which is rarely reported in CRC, and confirmed that its inhibitory effect on CRC is related to fatty acid degradation.https://www.frontiersin.org/articles/10.3389/fonc.2022.870721/fullEPHX2CRCmetabolic reprogrammingfatty acid degradationROSlipid droplet |
| spellingShingle | Yiran Zhou Yiran Zhou Xiao Li Xiao Li Aoran Guan Aoran Guan Haodong Zhou Haodong Zhou Yankun Zhu Yankun Zhu Ruotian Wang Ruotian Wang Ruhong Li Ruhong Li EPHX2 Inhibits Colon Cancer Progression by Promoting Fatty Acid Degradation Frontiers in Oncology EPHX2 CRC metabolic reprogramming fatty acid degradation ROS lipid droplet |
| title | EPHX2 Inhibits Colon Cancer Progression by Promoting Fatty Acid Degradation |
| title_full | EPHX2 Inhibits Colon Cancer Progression by Promoting Fatty Acid Degradation |
| title_fullStr | EPHX2 Inhibits Colon Cancer Progression by Promoting Fatty Acid Degradation |
| title_full_unstemmed | EPHX2 Inhibits Colon Cancer Progression by Promoting Fatty Acid Degradation |
| title_short | EPHX2 Inhibits Colon Cancer Progression by Promoting Fatty Acid Degradation |
| title_sort | ephx2 inhibits colon cancer progression by promoting fatty acid degradation |
| topic | EPHX2 CRC metabolic reprogramming fatty acid degradation ROS lipid droplet |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.870721/full |
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