The Potential of Omics in Biological Dosimetry
Biological dosimetry is an internationally recognized method for quantifying and estimating radiation dose following suspected or verified excessive exposure to ionising radiation. In severe radiation accidents where a large number of people are potentially affected, it is possible to distinguish ir...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Radiation |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-592X/2/1/6 |
| _version_ | 1797442945905852416 |
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| author | Daniela Hladik Martin Bucher David Endesfelder Ursula Oestreicher |
| author_facet | Daniela Hladik Martin Bucher David Endesfelder Ursula Oestreicher |
| author_sort | Daniela Hladik |
| collection | DOAJ |
| description | Biological dosimetry is an internationally recognized method for quantifying and estimating radiation dose following suspected or verified excessive exposure to ionising radiation. In severe radiation accidents where a large number of people are potentially affected, it is possible to distinguish irradiated from non-irradiated people in order to initiate appropriate medical care if necessary. In addition to severe incidents caused by technical failure, environmental disasters, military actions, or criminal abuse, there are also radiation accidents in which only one or a few individuals are affected in the frame of occupational or medical exposure. The requirements for biological dosimetry are fundamentally different for these two scenarios. In particular, for large-scale radiation accidents, pre-screening methods are necessary to increase the throughput of samples for a rough first-dose categorization. The rapid development and increasing use of omics methods in research as well as in individual applications provides new opportunities for biological dosimetry. In addition to the discovery and search for new biomarkers, dosimetry assays based on omics technologies are becoming increasingly interesting and hold great potential, especially for large-scale dosimetry. In the following review, the different areas of biological dosimetry, the problems in finding suitable biomarkers, the current status of biomarker research based on omics, the potential applications of assays using omics technologies, and also the limitations for the different areas of biological dosimetry are discussed. |
| first_indexed | 2024-03-09T12:48:59Z |
| format | Article |
| id | doaj.art-6685faffcb164ef88b32c2c7456d0de1 |
| institution | Directory Open Access Journal |
| issn | 2673-592X |
| language | English |
| last_indexed | 2024-03-09T12:48:59Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Radiation |
| spelling | doaj.art-6685faffcb164ef88b32c2c7456d0de12023-11-30T22:09:11ZengMDPI AGRadiation2673-592X2022-01-0121789010.3390/radiation2010006The Potential of Omics in Biological DosimetryDaniela Hladik0Martin Bucher1David Endesfelder2Ursula Oestreicher3Federal Office for Radiation Protection (BfS), Department of Effects and Risks of Ionising and Non-Ionising Radiation, 85764 Oberschleissheim, GermanyFederal Office for Radiation Protection (BfS), Department of Effects and Risks of Ionising and Non-Ionising Radiation, 85764 Oberschleissheim, GermanyFederal Office for Radiation Protection (BfS), Department of Effects and Risks of Ionising and Non-Ionising Radiation, 85764 Oberschleissheim, GermanyFederal Office for Radiation Protection (BfS), Department of Effects and Risks of Ionising and Non-Ionising Radiation, 85764 Oberschleissheim, GermanyBiological dosimetry is an internationally recognized method for quantifying and estimating radiation dose following suspected or verified excessive exposure to ionising radiation. In severe radiation accidents where a large number of people are potentially affected, it is possible to distinguish irradiated from non-irradiated people in order to initiate appropriate medical care if necessary. In addition to severe incidents caused by technical failure, environmental disasters, military actions, or criminal abuse, there are also radiation accidents in which only one or a few individuals are affected in the frame of occupational or medical exposure. The requirements for biological dosimetry are fundamentally different for these two scenarios. In particular, for large-scale radiation accidents, pre-screening methods are necessary to increase the throughput of samples for a rough first-dose categorization. The rapid development and increasing use of omics methods in research as well as in individual applications provides new opportunities for biological dosimetry. In addition to the discovery and search for new biomarkers, dosimetry assays based on omics technologies are becoming increasingly interesting and hold great potential, especially for large-scale dosimetry. In the following review, the different areas of biological dosimetry, the problems in finding suitable biomarkers, the current status of biomarker research based on omics, the potential applications of assays using omics technologies, and also the limitations for the different areas of biological dosimetry are discussed.https://www.mdpi.com/2673-592X/2/1/6biological dosimetryomicstranscriptomicsproteomicsmetabolomics |
| spellingShingle | Daniela Hladik Martin Bucher David Endesfelder Ursula Oestreicher The Potential of Omics in Biological Dosimetry Radiation biological dosimetry omics transcriptomics proteomics metabolomics |
| title | The Potential of Omics in Biological Dosimetry |
| title_full | The Potential of Omics in Biological Dosimetry |
| title_fullStr | The Potential of Omics in Biological Dosimetry |
| title_full_unstemmed | The Potential of Omics in Biological Dosimetry |
| title_short | The Potential of Omics in Biological Dosimetry |
| title_sort | potential of omics in biological dosimetry |
| topic | biological dosimetry omics transcriptomics proteomics metabolomics |
| url | https://www.mdpi.com/2673-592X/2/1/6 |
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