Dystrophin-Glycoprotein Complex Behavior in Sternocleidomastoid Muscle of High- and Low-Ranking Baboons: A Possible Phylogenetic Arrangement
The dystrophin-glycoprotein complex is a multimeric system made up of the sarcoglycan sub-complex, the sarcomplasmatic complex and the dystroglycans complex. The sarcoglycan sub-complex stabilizes the sarcolemma during muscle activity and plays a role in force transduction. This protein system is al...
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MDPI AG
2022-08-01
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| Series: | Journal of Functional Morphology and Kinesiology |
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| Online Access: | https://www.mdpi.com/2411-5142/7/3/62 |
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| author | Antonio Centofanti Giovanna Vermiglio Giuseppina Cutroneo Angelo Favaloro Giacomo Picciolo Felice Festa Giuseppe Pio Anastasi |
| author_facet | Antonio Centofanti Giovanna Vermiglio Giuseppina Cutroneo Angelo Favaloro Giacomo Picciolo Felice Festa Giuseppe Pio Anastasi |
| author_sort | Antonio Centofanti |
| collection | DOAJ |
| description | The dystrophin-glycoprotein complex is a multimeric system made up of the sarcoglycan sub-complex, the sarcomplasmatic complex and the dystroglycans complex. The sarcoglycan sub-complex stabilizes the sarcolemma during muscle activity and plays a role in force transduction. This protein system is also expressed in the muscle of non-human primates such as chimpanzees and baboons, and its expression changes depending on social ranking. In fact, previous data have shown that all muscle fibers of masseter and sternocleidomastoid muscles of chimpanzees and high- ranking baboons always express sarcoglycans, while middle- and low-ranking baboons are characterized by fibers that are negative for the sarcoglycan sub-complex. Given this information, the aim of the present work was to evaluate the expression of other proteins such as laminin, beta dystroglycan and dystrophin in the sternocleidomastoid muscle of high- and low-ranking baboons. The samples were processed by immunohistochemistry; results show that in high-ranking baboons, all tested proteins were always expressed while in low-ranking baboons, fibers that were negative for sarcoglycans and beta dystroglycan have been observed. No negative fibers for laminin and dystrophin have been found in low-ranking baboons suggesting that only the transmembrane proteins of the dystrophin glycoprotein complex change in their expression and that could be correlated to a phylogenetic arrangement. |
| first_indexed | 2024-03-09T23:34:06Z |
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| institution | Directory Open Access Journal |
| issn | 2411-5142 |
| language | English |
| last_indexed | 2024-03-09T23:34:06Z |
| publishDate | 2022-08-01 |
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| series | Journal of Functional Morphology and Kinesiology |
| spelling | doaj.art-66874750724c430e9468b4efa16fabe02023-11-23T17:04:12ZengMDPI AGJournal of Functional Morphology and Kinesiology2411-51422022-08-01736210.3390/jfmk7030062Dystrophin-Glycoprotein Complex Behavior in Sternocleidomastoid Muscle of High- and Low-Ranking Baboons: A Possible Phylogenetic ArrangementAntonio Centofanti0Giovanna Vermiglio1Giuseppina Cutroneo2Angelo Favaloro3Giacomo Picciolo4Felice Festa5Giuseppe Pio Anastasi6Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, ItalyDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, ItalyDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, ItalyDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, ItalyDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, ItalyDepartment of Innovative Technologies in Medicine and Dentistry, University “G. D’Annunzio” of Chieti-Pescara, 66100 Chieti, ItalyDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, ItalyThe dystrophin-glycoprotein complex is a multimeric system made up of the sarcoglycan sub-complex, the sarcomplasmatic complex and the dystroglycans complex. The sarcoglycan sub-complex stabilizes the sarcolemma during muscle activity and plays a role in force transduction. This protein system is also expressed in the muscle of non-human primates such as chimpanzees and baboons, and its expression changes depending on social ranking. In fact, previous data have shown that all muscle fibers of masseter and sternocleidomastoid muscles of chimpanzees and high- ranking baboons always express sarcoglycans, while middle- and low-ranking baboons are characterized by fibers that are negative for the sarcoglycan sub-complex. Given this information, the aim of the present work was to evaluate the expression of other proteins such as laminin, beta dystroglycan and dystrophin in the sternocleidomastoid muscle of high- and low-ranking baboons. The samples were processed by immunohistochemistry; results show that in high-ranking baboons, all tested proteins were always expressed while in low-ranking baboons, fibers that were negative for sarcoglycans and beta dystroglycan have been observed. No negative fibers for laminin and dystrophin have been found in low-ranking baboons suggesting that only the transmembrane proteins of the dystrophin glycoprotein complex change in their expression and that could be correlated to a phylogenetic arrangement.https://www.mdpi.com/2411-5142/7/3/62baboonsternocleidomastoid muscleimmunofluorescenceSGCDGCdystroglycans |
| spellingShingle | Antonio Centofanti Giovanna Vermiglio Giuseppina Cutroneo Angelo Favaloro Giacomo Picciolo Felice Festa Giuseppe Pio Anastasi Dystrophin-Glycoprotein Complex Behavior in Sternocleidomastoid Muscle of High- and Low-Ranking Baboons: A Possible Phylogenetic Arrangement Journal of Functional Morphology and Kinesiology baboon sternocleidomastoid muscle immunofluorescence SGC DGC dystroglycans |
| title | Dystrophin-Glycoprotein Complex Behavior in Sternocleidomastoid Muscle of High- and Low-Ranking Baboons: A Possible Phylogenetic Arrangement |
| title_full | Dystrophin-Glycoprotein Complex Behavior in Sternocleidomastoid Muscle of High- and Low-Ranking Baboons: A Possible Phylogenetic Arrangement |
| title_fullStr | Dystrophin-Glycoprotein Complex Behavior in Sternocleidomastoid Muscle of High- and Low-Ranking Baboons: A Possible Phylogenetic Arrangement |
| title_full_unstemmed | Dystrophin-Glycoprotein Complex Behavior in Sternocleidomastoid Muscle of High- and Low-Ranking Baboons: A Possible Phylogenetic Arrangement |
| title_short | Dystrophin-Glycoprotein Complex Behavior in Sternocleidomastoid Muscle of High- and Low-Ranking Baboons: A Possible Phylogenetic Arrangement |
| title_sort | dystrophin glycoprotein complex behavior in sternocleidomastoid muscle of high and low ranking baboons a possible phylogenetic arrangement |
| topic | baboon sternocleidomastoid muscle immunofluorescence SGC DGC dystroglycans |
| url | https://www.mdpi.com/2411-5142/7/3/62 |
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