Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation
Summary: Long interspersed nuclear element-1 (L1 or LINE-1) is a highly abundant mobile genetic element in both humans and mice, comprising almost 20% of each genome. L1s are silenced by several mechanisms, as their uncontrolled expression has the potential to induce genomic instability. However, L1...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124724001025 |
| _version_ | 1797291769302351872 |
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| author | Tomohisa Toda Tracy A. Bedrosian Simon T. Schafer Michael S. Cuoco Sara B. Linker Saeed Ghassemzadeh Lisa Mitchell Jack T. Whiteley Nicole Novaresi Aidan H. McDonald Iryna S. Gallina Hyojung Yoon Mark E. Hester Monique Pena Christina Lim Emelia Suljic Abed AlFatah Mansour Matthieu Boulard Sarah L. Parylak Fred H. Gage |
| author_facet | Tomohisa Toda Tracy A. Bedrosian Simon T. Schafer Michael S. Cuoco Sara B. Linker Saeed Ghassemzadeh Lisa Mitchell Jack T. Whiteley Nicole Novaresi Aidan H. McDonald Iryna S. Gallina Hyojung Yoon Mark E. Hester Monique Pena Christina Lim Emelia Suljic Abed AlFatah Mansour Matthieu Boulard Sarah L. Parylak Fred H. Gage |
| author_sort | Tomohisa Toda |
| collection | DOAJ |
| description | Summary: Long interspersed nuclear element-1 (L1 or LINE-1) is a highly abundant mobile genetic element in both humans and mice, comprising almost 20% of each genome. L1s are silenced by several mechanisms, as their uncontrolled expression has the potential to induce genomic instability. However, L1s are paradoxically expressed at high levels in differentiating neural progenitor cells. Using in vitro and in vivo techniques to modulate L1 expression, we report that L1s play a critical role in both human and mouse brain development by regulating the rate of neural differentiation in a reverse-transcription-independent manner. |
| first_indexed | 2024-03-07T19:42:30Z |
| format | Article |
| id | doaj.art-6688623518d44adfa7c2bcdc893f7bd4 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-07T19:42:30Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-6688623518d44adfa7c2bcdc893f7bd42024-02-29T05:18:56ZengElsevierCell Reports2211-12472024-02-01432113774Long interspersed nuclear elements safeguard neural progenitors from precocious differentiationTomohisa Toda0Tracy A. Bedrosian1Simon T. Schafer2Michael S. Cuoco3Sara B. Linker4Saeed Ghassemzadeh5Lisa Mitchell6Jack T. Whiteley7Nicole Novaresi8Aidan H. McDonald9Iryna S. Gallina10Hyojung Yoon11Mark E. Hester12Monique Pena13Christina Lim14Emelia Suljic15Abed AlFatah Mansour16Matthieu Boulard17Sarah L. Parylak18Fred H. Gage19Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA; Laboratory of Neural Epigenomics, Institute of Medical Physics and Micro-tissue Engineering, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany; Nuclear Architecture in Neural Plasticity and Aging Laboratory, German Center for Neurodegenerative Diseases, 01307 Dresden, Germany; Corresponding authorLaboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA; Institute for Genomic Medicine, Nationwide Children’s Hospital, Columbus, OH 43205, USALaboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA; Department of Psychiatry and Psychotherapy, School of Medicine and Health, Technical University of Munich, Munich, Germany; TUM Center for Organoid Systems (COS), Munich Institute of Biomedical Engineering, Garching, GermanyLaboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA; Computational Neural DNA Dynamics Lab, Department of Cognitive Science, University of California, San Diego, San Diego, CA, USA; Bioinformatics and Systems Biology Graduate Program, University of California, San Diego, San Diego, CA, USALaboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USALaboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USALaboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USALaboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USALaboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USALaboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USALaboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USAInstitute for Genomic Medicine, Nationwide Children’s Hospital, Columbus, OH 43205, USAInstitute for Genomic Medicine, Nationwide Children’s Hospital, Columbus, OH 43205, USALaboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA; Department of Psychiatry and Psychotherapy, School of Medicine and Health, Technical University of Munich, Munich, Germany; TUM Center for Organoid Systems (COS), Munich Institute of Biomedical Engineering, Garching, GermanyLaboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USALaboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USALaboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USAEpigenetics & Neurobiology Unit, EMBL Rome, European Molecular Biology Laboratory, Via Ramarini 32, 00015 Monterotondo, ItalyLaboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USALaboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA; Corresponding authorSummary: Long interspersed nuclear element-1 (L1 or LINE-1) is a highly abundant mobile genetic element in both humans and mice, comprising almost 20% of each genome. L1s are silenced by several mechanisms, as their uncontrolled expression has the potential to induce genomic instability. However, L1s are paradoxically expressed at high levels in differentiating neural progenitor cells. Using in vitro and in vivo techniques to modulate L1 expression, we report that L1s play a critical role in both human and mouse brain development by regulating the rate of neural differentiation in a reverse-transcription-independent manner.http://www.sciencedirect.com/science/article/pii/S2211124724001025CP: Developmental biologyCP: Neuroscience |
| spellingShingle | Tomohisa Toda Tracy A. Bedrosian Simon T. Schafer Michael S. Cuoco Sara B. Linker Saeed Ghassemzadeh Lisa Mitchell Jack T. Whiteley Nicole Novaresi Aidan H. McDonald Iryna S. Gallina Hyojung Yoon Mark E. Hester Monique Pena Christina Lim Emelia Suljic Abed AlFatah Mansour Matthieu Boulard Sarah L. Parylak Fred H. Gage Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation Cell Reports CP: Developmental biology CP: Neuroscience |
| title | Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation |
| title_full | Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation |
| title_fullStr | Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation |
| title_full_unstemmed | Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation |
| title_short | Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation |
| title_sort | long interspersed nuclear elements safeguard neural progenitors from precocious differentiation |
| topic | CP: Developmental biology CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124724001025 |
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