Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation

Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation

Summary: Long interspersed nuclear element-1 (L1 or LINE-1) is a highly abundant mobile genetic element in both humans and mice, comprising almost 20% of each genome. L1s are silenced by several mechanisms, as their uncontrolled expression has the potential to induce genomic instability. However, L1...

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Bibliographic Details
Main Authors: Tomohisa Toda, Tracy A. Bedrosian, Simon T. Schafer, Michael S. Cuoco, Sara B. Linker, Saeed Ghassemzadeh, Lisa Mitchell, Jack T. Whiteley, Nicole Novaresi, Aidan H. McDonald, Iryna S. Gallina, Hyojung Yoon, Mark E. Hester, Monique Pena, Christina Lim, Emelia Suljic, Abed AlFatah Mansour, Matthieu Boulard, Sarah L. Parylak, Fred H. Gage
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Cell Reports
Subjects:
CP: Developmental biology
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724001025

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