m6 RNA methylation: an emerging common target in the immune response to cancer and severe acute respiratory syndrome-coronavirus-2 infection
m6A RNA methylation, a predominant type of RNA modification, is involved in regulating mRNA splicing, stability, and translation as well as the interaction between nucleoproteins and noncoding RNAs. Recent studies have revealed that m6A RNA methylation plays a critical role in the self-to-non-self-r...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Open Exploration Publishing Inc.
2023-02-01
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| Series: | Exploration of Medicine |
| Subjects: | |
| Online Access: | https://www.explorationpub.com/Journals/em/Article/1001127 |
| _version_ | 1811161989279383552 |
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| author | Hiromichi Sato Tomoaki Hara Chihiro Otsuka Yasuko Arao Yoshiko Tsuji Yumiko Hamano Mirei Ogita Eric di Luccio Takaaki Hirotsu Andrea Vecchione Hideshi Ishii |
| author_facet | Hiromichi Sato Tomoaki Hara Chihiro Otsuka Yasuko Arao Yoshiko Tsuji Yumiko Hamano Mirei Ogita Eric di Luccio Takaaki Hirotsu Andrea Vecchione Hideshi Ishii |
| author_sort | Hiromichi Sato |
| collection | DOAJ |
| description | m6A RNA methylation, a predominant type of RNA modification, is involved in regulating mRNA splicing, stability, and translation as well as the interaction between nucleoproteins and noncoding RNAs. Recent studies have revealed that m6A RNA methylation plays a critical role in the self-to-non-self-recognition of immune cells against endogenous mutations in cancer and exogenous organism-related infections. As an epigenetic mechanism, m6A RNA modification induces immune cell signal transduction, which is altered in the tumor microenvironment, as detected in liquid biopsy. Furthermore, m6A RNA methylation-related inflammation is involved in the cellular response to viral infections, including the emerging severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection. Given the importance of the immune response in maintaining homeostasis in higher eukaryotes, m6A RNA methylation could be useful not only for the early detection of cancer but also for SARS-CoV-2 screening during a global pandemic. |
| first_indexed | 2024-04-10T06:22:47Z |
| format | Article |
| id | doaj.art-66895b87b39648d38e8f4bff0a352faf |
| institution | Directory Open Access Journal |
| issn | 2692-3106 |
| language | English |
| last_indexed | 2024-04-10T06:22:47Z |
| publishDate | 2023-02-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Medicine |
| spelling | doaj.art-66895b87b39648d38e8f4bff0a352faf2023-03-02T01:48:06ZengOpen Exploration Publishing Inc.Exploration of Medicine2692-31062023-02-014110711410.37349/emed.2023.00127m6 RNA methylation: an emerging common target in the immune response to cancer and severe acute respiratory syndrome-coronavirus-2 infectionHiromichi Sato0https://orcid.org/0000-0002-6364-0553Tomoaki Hara1Chihiro Otsuka2Yasuko Arao3Yoshiko Tsuji4Yumiko Hamano5Mirei Ogita6Eric di Luccio7Takaaki Hirotsu8Andrea Vecchione9Hideshi Ishii10https://orcid.org/0000-0002-0632-6517Department of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Suita, Yamadaoka 2-2, Osaka 565-0871, Japan; Department of Gastrointestinal Surgery, Osaka University Graduate School of Medicine, Suita, Yamadaoka 2-2, Osaka 565-0871, JapanDepartment of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Suita, Yamadaoka 2-2, Osaka 565-0871, JapanDepartment of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Suita, Yamadaoka 2-2, Osaka 565-0871, JapanDepartment of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Suita, Yamadaoka 2-2, Osaka 565-0871, JapanDepartment of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Suita, Yamadaoka 2-2, Osaka 565-0871, JapanDepartment of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Suita, Yamadaoka 2-2, Osaka 565-0871, JapanDepartment of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Suita, Yamadaoka 2-2, Osaka 565-0871, JapanHirotsu Bio Science Inc., Chiyoda-Ku, Tokyo 102-0094, JapanHirotsu Bio Science Inc., Chiyoda-Ku, Tokyo 102-0094, JapanDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Santo Andrea Hospital, Via di Grottarossa, 1035- 00189 Rome, ItalyDepartment of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Suita, Yamadaoka 2-2, Osaka 565-0871, Japanm6A RNA methylation, a predominant type of RNA modification, is involved in regulating mRNA splicing, stability, and translation as well as the interaction between nucleoproteins and noncoding RNAs. Recent studies have revealed that m6A RNA methylation plays a critical role in the self-to-non-self-recognition of immune cells against endogenous mutations in cancer and exogenous organism-related infections. As an epigenetic mechanism, m6A RNA modification induces immune cell signal transduction, which is altered in the tumor microenvironment, as detected in liquid biopsy. Furthermore, m6A RNA methylation-related inflammation is involved in the cellular response to viral infections, including the emerging severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection. Given the importance of the immune response in maintaining homeostasis in higher eukaryotes, m6A RNA methylation could be useful not only for the early detection of cancer but also for SARS-CoV-2 screening during a global pandemic.https://www.explorationpub.com/Journals/em/Article/1001127rnamethylationm6acancersevere acute respiratory syndrome-coronavirus-2 |
| spellingShingle | Hiromichi Sato Tomoaki Hara Chihiro Otsuka Yasuko Arao Yoshiko Tsuji Yumiko Hamano Mirei Ogita Eric di Luccio Takaaki Hirotsu Andrea Vecchione Hideshi Ishii m6 RNA methylation: an emerging common target in the immune response to cancer and severe acute respiratory syndrome-coronavirus-2 infection Exploration of Medicine rna methylation m6a cancer severe acute respiratory syndrome-coronavirus-2 |
| title | m6 RNA methylation: an emerging common target in the immune response to cancer and severe acute respiratory syndrome-coronavirus-2 infection |
| title_full | m6 RNA methylation: an emerging common target in the immune response to cancer and severe acute respiratory syndrome-coronavirus-2 infection |
| title_fullStr | m6 RNA methylation: an emerging common target in the immune response to cancer and severe acute respiratory syndrome-coronavirus-2 infection |
| title_full_unstemmed | m6 RNA methylation: an emerging common target in the immune response to cancer and severe acute respiratory syndrome-coronavirus-2 infection |
| title_short | m6 RNA methylation: an emerging common target in the immune response to cancer and severe acute respiratory syndrome-coronavirus-2 infection |
| title_sort | m6 rna methylation an emerging common target in the immune response to cancer and severe acute respiratory syndrome coronavirus 2 infection |
| topic | rna methylation m6a cancer severe acute respiratory syndrome-coronavirus-2 |
| url | https://www.explorationpub.com/Journals/em/Article/1001127 |
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