Alpha-Ketoglutarate or 5-HMF: Single Compounds Effectively Eliminate Leukemia Cells via Caspase-3 Apoptosis and Antioxidative Pathways

Alpha-Ketoglutarate or 5-HMF: Single Compounds Effectively Eliminate Leukemia Cells via Caspase-3 Apoptosis and Antioxidative Pathways

Background: We recently showed that a combined solution containing alpha-ketoglutarate (aKG) and 5-hydroxymethyl-furfural (5-HMF) has a solid antitumoral effect on the Jurkat cell line due to the fact of its antioxidative, caspase-3 and apoptosis activities, but no negative effect on human fibroblas...

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Bibliographic Details
Main Authors: Joachim Greilberger, Ralf Herwig, Mehtap Kacar, Naime Brajshori, Georg Feigl, Philipp Stiegler, Reinhold Wintersteiger
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
alpha-ketoglutarate (aKG)
5-hydroxy-methyl-furfural (5-HMF)
reactive oxygen and nitrogen species (RONS)
peroxynitrite (ONOO<sup>−</sup>)
nitrated tyrosine
leukemia
Online Access:https://www.mdpi.com/1422-0067/23/16/9034

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https://www.mdpi.com/1422-0067/23/16/9034

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