Thymidine phosphorylase and its possible correlation with the lung cancer phenotype features
The tumor phenotype investigation is necessary for lung cancer drug therapy optimization. For this purpose is perspective to use the biochemical markers of angiogenesis. Thymidine phosphorylase may be one of them. Aim. The aim of study was to evaluate the correlation between the enzyme activity i...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Zaporozhye State Medical University
2015-04-01
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| Series: | Patologìâ |
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| Online Access: | http://pat.zsmu.edu.ua/article/view/42882/39282 |
| _version_ | 1811312243470499840 |
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| author | E. M. Bakurova R. V. Buzina R. B. Kondratiuk Yu. K. Gulkov I. V. Vasilenko B. G. Borzenko |
| author_facet | E. M. Bakurova R. V. Buzina R. B. Kondratiuk Yu. K. Gulkov I. V. Vasilenko B. G. Borzenko |
| author_sort | E. M. Bakurova |
| collection | DOAJ |
| description | The tumor phenotype investigation is necessary for lung cancer drug therapy optimization. For this purpose is perspective to use the biochemical markers of angiogenesis. Thymidine phosphorylase may be one of them.
Aim. The aim of study was to evaluate the correlation between the enzyme activity in tumors and the levels of expression of the vascular endothelial marker CD34.
Methods and results. They were examined spectrophotometrically and by the immunohistochemical method, respectively, in 25 samples of lung cancer tissues. It was shown that its activity in tumors is higher as compared to non-neoplastic adjacent tissues (from 30 to150 nmol/min·mg; in 20 cases from total number). The enzyme activity changes were dependent of the levels of the CD 34, a positive correlation between them was shown (the index of Spearman’s rank correlation, i.e. ρ = 0,668; p<0,05).
Conclusion. These findings suggest the possibility of using thymidine phosphorylase as a biochemical marker of angiogenesis, its relationship with the lung cancer phenotype features. |
| first_indexed | 2024-04-13T10:33:57Z |
| format | Article |
| id | doaj.art-668cd190e4ff4174bceba017cd1b9645 |
| institution | Directory Open Access Journal |
| issn | 2306-8027 2310-1237 |
| language | English |
| last_indexed | 2024-04-13T10:33:57Z |
| publishDate | 2015-04-01 |
| publisher | Zaporozhye State Medical University |
| record_format | Article |
| series | Patologìâ |
| spelling | doaj.art-668cd190e4ff4174bceba017cd1b96452022-12-22T02:50:07ZengZaporozhye State Medical UniversityPatologìâ2306-80272310-12372015-04-011535510.14739/2310-1237.2015.1.42882Thymidine phosphorylase and its possible correlation with the lung cancer phenotype featuresE. M. BakurovaR. V. BuzinaR. B. Kondratiuk Yu. K. GulkovI. V. VasilenkoB. G. BorzenkoThe tumor phenotype investigation is necessary for lung cancer drug therapy optimization. For this purpose is perspective to use the biochemical markers of angiogenesis. Thymidine phosphorylase may be one of them. Aim. The aim of study was to evaluate the correlation between the enzyme activity in tumors and the levels of expression of the vascular endothelial marker CD34. Methods and results. They were examined spectrophotometrically and by the immunohistochemical method, respectively, in 25 samples of lung cancer tissues. It was shown that its activity in tumors is higher as compared to non-neoplastic adjacent tissues (from 30 to150 nmol/min·mg; in 20 cases from total number). The enzyme activity changes were dependent of the levels of the CD 34, a positive correlation between them was shown (the index of Spearman’s rank correlation, i.e. ρ = 0,668; p<0,05). Conclusion. These findings suggest the possibility of using thymidine phosphorylase as a biochemical marker of angiogenesis, its relationship with the lung cancer phenotype features.http://pat.zsmu.edu.ua/article/view/42882/39282Thymidine PhosphorylaseLung NeoplasmsNeovascularization Pathologic |
| spellingShingle | E. M. Bakurova R. V. Buzina R. B. Kondratiuk Yu. K. Gulkov I. V. Vasilenko B. G. Borzenko Thymidine phosphorylase and its possible correlation with the lung cancer phenotype features Patologìâ Thymidine Phosphorylase Lung Neoplasms Neovascularization Pathologic |
| title | Thymidine phosphorylase and its possible correlation with the lung cancer phenotype features |
| title_full | Thymidine phosphorylase and its possible correlation with the lung cancer phenotype features |
| title_fullStr | Thymidine phosphorylase and its possible correlation with the lung cancer phenotype features |
| title_full_unstemmed | Thymidine phosphorylase and its possible correlation with the lung cancer phenotype features |
| title_short | Thymidine phosphorylase and its possible correlation with the lung cancer phenotype features |
| title_sort | thymidine phosphorylase and its possible correlation with the lung cancer phenotype features |
| topic | Thymidine Phosphorylase Lung Neoplasms Neovascularization Pathologic |
| url | http://pat.zsmu.edu.ua/article/view/42882/39282 |
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