Synthesis, Characterization, and Antibacterial Studies of New Cu(II) and Pd(II) Complexes with 6-Methyl-2-Thiouracil and 6-Propyl-2-Thiouracil
The aim of the present study is to synthesize new metal complexes of 6-methyl-2-thiouracil and 6-propyl-2-thiouracil, elucidate their structures, and investigate their biological properties. All metal complexes were obtained after mixing water solutions of the corresponding metal salts and the ligan...
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| Format: | Article |
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MDPI AG
2023-12-01
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| Online Access: | https://www.mdpi.com/2076-3417/13/24/13150 |
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| author | Petya Marinova Mariyan Hristov Slava Tsoneva Nikola Burdzhiev Denica Blazheva Aleksandar Slavchev Evelina Varbanova Plamen Penchev |
| author_facet | Petya Marinova Mariyan Hristov Slava Tsoneva Nikola Burdzhiev Denica Blazheva Aleksandar Slavchev Evelina Varbanova Plamen Penchev |
| author_sort | Petya Marinova |
| collection | DOAJ |
| description | The aim of the present study is to synthesize new metal complexes of 6-methyl-2-thiouracil and 6-propyl-2-thiouracil, elucidate their structures, and investigate their biological properties. All metal complexes were obtained after mixing water solutions of the corresponding metal salts and the ligand dissolved in DMSO and water solutions of NaOH in a metal-to-ligand ratio of 1:4:2. The structures of the new compounds are discussed based on melting point analysis (MP-AES) for Cu and Pd, UV-Vis, IR, ATR, <sup>1</sup>H NMR, <sup>13</sup>C NMR, and Raman spectroscopy. The interpretation of complex spectra is assisted by the data for 6-methyl-2-thiouracil and 6-propyl-2-thiouracil obtained from <sup>1</sup>H-<sup>1</sup>H COSY, DEPT-135, HMBC and HMQC spectra. In addition, the antimicrobial activity of these complexes and the free ligands are assessed against both Gram-positive and Gram-negative bacteria, as well as yeasts. In general, the addition of metal ions improved the antimicrobial activity of both 6-methyl-2-thiouracil and 6-propyl-2-thiouracil. The Cu(II) complex with 6-methyl-2-thiouracil and the Pd(II) complex with 6-propyl-2-thiouracil exhibited the highest activity against the test microorganisms. |
| first_indexed | 2024-03-08T21:01:34Z |
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| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-08T21:01:34Z |
| publishDate | 2023-12-01 |
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| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-668f05137be94114aa9eba1699595a3b2023-12-22T13:51:38ZengMDPI AGApplied Sciences2076-34172023-12-0113241315010.3390/app132413150Synthesis, Characterization, and Antibacterial Studies of New Cu(II) and Pd(II) Complexes with 6-Methyl-2-Thiouracil and 6-Propyl-2-ThiouracilPetya Marinova0Mariyan Hristov1Slava Tsoneva2Nikola Burdzhiev3Denica Blazheva4Aleksandar Slavchev5Evelina Varbanova6Plamen Penchev7Department of General and Inorganic Chemistry with Methodology of Chemistry Education, Faculty of Chemistry, “Tzar Assen” Str. 24, 4000 Plovdiv, BulgariaDepartment of General and Inorganic Chemistry with Methodology of Chemistry Education, Faculty of Chemistry, “Tzar Assen” Str. 24, 4000 Plovdiv, BulgariaDepartment of Analytical Chemistry and Computer Chemistry, Faculty of Chemistry, University of Plovdiv, “Tzar Asen” Str. 24, 4000 Plovdiv, BulgariaDepartment of Organic Chemistry and Pharmacognosy, Faculty of Chemistry and Pharmacy, University of Sofia, 1, J. Bourchier Av., 1164 Sofia, BulgariaDepartment of Microbiology, University of Food Technologies, 26 Maritza Blvd., 4002 Plovdiv, BulgariaDepartment of Microbiology, University of Food Technologies, 26 Maritza Blvd., 4002 Plovdiv, BulgariaDepartment of Analytical Chemistry and Computer Chemistry, Faculty of Chemistry, University of Plovdiv, “Tzar Asen” Str. 24, 4000 Plovdiv, BulgariaDepartment of Analytical Chemistry and Computer Chemistry, Faculty of Chemistry, University of Plovdiv, “Tzar Asen” Str. 24, 4000 Plovdiv, BulgariaThe aim of the present study is to synthesize new metal complexes of 6-methyl-2-thiouracil and 6-propyl-2-thiouracil, elucidate their structures, and investigate their biological properties. All metal complexes were obtained after mixing water solutions of the corresponding metal salts and the ligand dissolved in DMSO and water solutions of NaOH in a metal-to-ligand ratio of 1:4:2. The structures of the new compounds are discussed based on melting point analysis (MP-AES) for Cu and Pd, UV-Vis, IR, ATR, <sup>1</sup>H NMR, <sup>13</sup>C NMR, and Raman spectroscopy. The interpretation of complex spectra is assisted by the data for 6-methyl-2-thiouracil and 6-propyl-2-thiouracil obtained from <sup>1</sup>H-<sup>1</sup>H COSY, DEPT-135, HMBC and HMQC spectra. In addition, the antimicrobial activity of these complexes and the free ligands are assessed against both Gram-positive and Gram-negative bacteria, as well as yeasts. In general, the addition of metal ions improved the antimicrobial activity of both 6-methyl-2-thiouracil and 6-propyl-2-thiouracil. The Cu(II) complex with 6-methyl-2-thiouracil and the Pd(II) complex with 6-propyl-2-thiouracil exhibited the highest activity against the test microorganisms.https://www.mdpi.com/2076-3417/13/24/13150antimicrobial activitycopper(II) complexes6-methyl-2-thiouracilpalladium(II) complexes6-propyl-2-thiouracil |
| spellingShingle | Petya Marinova Mariyan Hristov Slava Tsoneva Nikola Burdzhiev Denica Blazheva Aleksandar Slavchev Evelina Varbanova Plamen Penchev Synthesis, Characterization, and Antibacterial Studies of New Cu(II) and Pd(II) Complexes with 6-Methyl-2-Thiouracil and 6-Propyl-2-Thiouracil Applied Sciences antimicrobial activity copper(II) complexes 6-methyl-2-thiouracil palladium(II) complexes 6-propyl-2-thiouracil |
| title | Synthesis, Characterization, and Antibacterial Studies of New Cu(II) and Pd(II) Complexes with 6-Methyl-2-Thiouracil and 6-Propyl-2-Thiouracil |
| title_full | Synthesis, Characterization, and Antibacterial Studies of New Cu(II) and Pd(II) Complexes with 6-Methyl-2-Thiouracil and 6-Propyl-2-Thiouracil |
| title_fullStr | Synthesis, Characterization, and Antibacterial Studies of New Cu(II) and Pd(II) Complexes with 6-Methyl-2-Thiouracil and 6-Propyl-2-Thiouracil |
| title_full_unstemmed | Synthesis, Characterization, and Antibacterial Studies of New Cu(II) and Pd(II) Complexes with 6-Methyl-2-Thiouracil and 6-Propyl-2-Thiouracil |
| title_short | Synthesis, Characterization, and Antibacterial Studies of New Cu(II) and Pd(II) Complexes with 6-Methyl-2-Thiouracil and 6-Propyl-2-Thiouracil |
| title_sort | synthesis characterization and antibacterial studies of new cu ii and pd ii complexes with 6 methyl 2 thiouracil and 6 propyl 2 thiouracil |
| topic | antimicrobial activity copper(II) complexes 6-methyl-2-thiouracil palladium(II) complexes 6-propyl-2-thiouracil |
| url | https://www.mdpi.com/2076-3417/13/24/13150 |
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