Alpha and beta EEG power reflects L-dopa acute administration in parkinsonian patients
Aim. To evaluate the effect of an acute L-dopa administration on eye-closed resting state electroencephalographic (EEG) activity of cognitively preserved Parkinsonian patients. Methods. We examined 24 right-handed patients diagnosed as uncomplicated probable Parkinson’s disease (PD). Each patient un...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-11-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00302/full |
| _version_ | 1819069319789674496 |
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| author | Jean-Marc eMelgari Giuseppe eCurcio Giuseppe eCurcio Francesca eMastrolilli Gaetano eSalomone Laura eTrotta Mario eTombini Lazzaro edi Biase Federica eScrascia Rita eFini Emma eFabrizio Paolo M Rossini Paolo M Rossini Fabrizio eVernieri |
| author_facet | Jean-Marc eMelgari Giuseppe eCurcio Giuseppe eCurcio Francesca eMastrolilli Gaetano eSalomone Laura eTrotta Mario eTombini Lazzaro edi Biase Federica eScrascia Rita eFini Emma eFabrizio Paolo M Rossini Paolo M Rossini Fabrizio eVernieri |
| author_sort | Jean-Marc eMelgari |
| collection | DOAJ |
| description | Aim. To evaluate the effect of an acute L-dopa administration on eye-closed resting state electroencephalographic (EEG) activity of cognitively preserved Parkinsonian patients. Methods. We examined 24 right-handed patients diagnosed as uncomplicated probable Parkinson’s disease (PD). Each patient underwent UPDRS-part-III evaluation before and 60 minutes after an oral load of L-dopa-methyl-ester/carbidopa 250/25 mg. Resting condition eyes-closed EEG data were recorded both pre- and post L-dopa load. Absolute EEG power values were calculated at each scalp derivation for Delta, Theta, Alpha and Beta frequency bands. UPDRS scores (both global and subscale scores) and EEG data (power values of different frequency bands for each scalp derivation) were submitted to a statistical analysis to compare Pre e Post L-Dopa conditions. Finally, a correlation analysis was carried out between EEG spectral content and UPDRS scores. Results. Considering EEG power spectral analysis, no statistically significant differences arose on Delta and Theta bands after L-dopa intake. Conversely, Alpha and Beta rhythms significantly increased on centro-parietal scalp derivations, as a function of L-dopa administration. Correlation analysis indicated a significant negative correlation between Beta power increase on centro-parietal areas and UPDRS subscores (Rigidity of arms and Bradykinesia). A minor significant negative correlation was also found between Alpha band increase and resting tremor. Conclusions. Assuming that a significant change in EEG power spectrum after L-dopa intake may be related to dopaminergic mechanisms, our findings are consistent with the hypothesis that dopaminergic defective networks are implicated in cortical oscillatory abnormalities at rest in non-demented PD patients. |
| first_indexed | 2024-12-21T16:48:10Z |
| format | Article |
| id | doaj.art-6691c840f66645e89ba1c9e21bc0bf3f |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-21T16:48:10Z |
| publishDate | 2014-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-6691c840f66645e89ba1c9e21bc0bf3f2022-12-21T18:56:56ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652014-11-01610.3389/fnagi.2014.0030291243Alpha and beta EEG power reflects L-dopa acute administration in parkinsonian patientsJean-Marc eMelgari0Giuseppe eCurcio1Giuseppe eCurcio2Francesca eMastrolilli3Gaetano eSalomone4Laura eTrotta5Mario eTombini6Lazzaro edi Biase7Federica eScrascia8Rita eFini9Emma eFabrizio10Paolo M Rossini11Paolo M Rossini12Fabrizio eVernieri13Campus Bio-Medico UniversityUniversity of L’AquilaCasa di Cura S. RaffaeleCampus Bio-Medico UniversityCampus Bio-Medico UniversityCampus Bio-Medico UniversityCampus Bio-Medico UniversityCampus Bio-Medico UniversityCampus Bio-Medico UniversityCampus Bio-Medico UniversityCampus Bio-Medico UniversityCasa di Cura S. RaffaeleCatholic UniversityCampus Bio-Medico UniversityAim. To evaluate the effect of an acute L-dopa administration on eye-closed resting state electroencephalographic (EEG) activity of cognitively preserved Parkinsonian patients. Methods. We examined 24 right-handed patients diagnosed as uncomplicated probable Parkinson’s disease (PD). Each patient underwent UPDRS-part-III evaluation before and 60 minutes after an oral load of L-dopa-methyl-ester/carbidopa 250/25 mg. Resting condition eyes-closed EEG data were recorded both pre- and post L-dopa load. Absolute EEG power values were calculated at each scalp derivation for Delta, Theta, Alpha and Beta frequency bands. UPDRS scores (both global and subscale scores) and EEG data (power values of different frequency bands for each scalp derivation) were submitted to a statistical analysis to compare Pre e Post L-Dopa conditions. Finally, a correlation analysis was carried out between EEG spectral content and UPDRS scores. Results. Considering EEG power spectral analysis, no statistically significant differences arose on Delta and Theta bands after L-dopa intake. Conversely, Alpha and Beta rhythms significantly increased on centro-parietal scalp derivations, as a function of L-dopa administration. Correlation analysis indicated a significant negative correlation between Beta power increase on centro-parietal areas and UPDRS subscores (Rigidity of arms and Bradykinesia). A minor significant negative correlation was also found between Alpha band increase and resting tremor. Conclusions. Assuming that a significant change in EEG power spectrum after L-dopa intake may be related to dopaminergic mechanisms, our findings are consistent with the hypothesis that dopaminergic defective networks are implicated in cortical oscillatory abnormalities at rest in non-demented PD patients.http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00302/fullAlpha RhythmBeta RhythmLevodopaParkinson’s diseasequantitative EEGpower spectrum analysis |
| spellingShingle | Jean-Marc eMelgari Giuseppe eCurcio Giuseppe eCurcio Francesca eMastrolilli Gaetano eSalomone Laura eTrotta Mario eTombini Lazzaro edi Biase Federica eScrascia Rita eFini Emma eFabrizio Paolo M Rossini Paolo M Rossini Fabrizio eVernieri Alpha and beta EEG power reflects L-dopa acute administration in parkinsonian patients Frontiers in Aging Neuroscience Alpha Rhythm Beta Rhythm Levodopa Parkinson’s disease quantitative EEG power spectrum analysis |
| title | Alpha and beta EEG power reflects L-dopa acute administration in parkinsonian patients |
| title_full | Alpha and beta EEG power reflects L-dopa acute administration in parkinsonian patients |
| title_fullStr | Alpha and beta EEG power reflects L-dopa acute administration in parkinsonian patients |
| title_full_unstemmed | Alpha and beta EEG power reflects L-dopa acute administration in parkinsonian patients |
| title_short | Alpha and beta EEG power reflects L-dopa acute administration in parkinsonian patients |
| title_sort | alpha and beta eeg power reflects l dopa acute administration in parkinsonian patients |
| topic | Alpha Rhythm Beta Rhythm Levodopa Parkinson’s disease quantitative EEG power spectrum analysis |
| url | http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00302/full |
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