Locus-Specific DNA Methylation Editing in Melanoma Cell Lines Using a CRISPR-Based System

Locus-Specific DNA Methylation Editing in Melanoma Cell Lines Using a CRISPR-Based System

DNA methylation is a key epigenetic modification implicated in the pathogenesis of numerous human diseases, including cancer development and metastasis. Gene promoter methylation changes are widely associated with transcriptional deregulation and disease progression. The advent of CRISPR-based techn...

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Bibliographic Details
Main Authors: Jim Smith, Rakesh Banerjee, Reema Waly, Arthur Urbano, Gregory Gimenez, Robert Day, Michael R. Eccles, Robert J. Weeks, Aniruddha Chatterjee
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cancers
Subjects:
CRISPR
dCas9
SunTag
DNA methylation
epigenetic editing
melanoma
Online Access:https://www.mdpi.com/2072-6694/13/21/5433

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