Chalepin and Chalepensin: Occurrence, Biosynthesis and Therapeutic Potential
Dihydrofuranocoumarin, chalepin (<b>1</b>) and furanocoumarin, chalepensin (<b>2</b>) are 3-prenylated bioactive coumarins, first isolated from the well-known medicinal plant <i>Ruta chalepensis</i> L. (Fam: Rutaceae) but also distributed in various species of the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/6/1609 |
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| author | Lutfun Nahar Shaymaa Al-Majmaie Afaf Al-Groshi Azhar Rasul Satyajit D. Sarker |
| author_facet | Lutfun Nahar Shaymaa Al-Majmaie Afaf Al-Groshi Azhar Rasul Satyajit D. Sarker |
| author_sort | Lutfun Nahar |
| collection | DOAJ |
| description | Dihydrofuranocoumarin, chalepin (<b>1</b>) and furanocoumarin, chalepensin (<b>2</b>) are 3-prenylated bioactive coumarins, first isolated from the well-known medicinal plant <i>Ruta chalepensis</i> L. (Fam: Rutaceae) but also distributed in various species of the genera <i>Boenminghausenia</i>, <i>Clausena</i> and <i>Ruta</i>. The distribution of these compounds appears to be restricted to the plants of the family Rutaceae. To date, there have been a considerable number of bioactivity studies performed on coumarins <b>1</b> and <b>2</b>, which include their anticancer, antidiabetic, antifertility, antimicrobial, antiplatelet aggregation, antiprotozoal, antiviral and calcium antagonistic properties. This review article presents a critical appraisal of publications on bioactivity of these 3-prenylated coumarins in the light of their feasibility as novel therapeutic agents and investigate their natural distribution in the plant kingdom, as well as a plausible biosynthetic route. |
| first_indexed | 2024-03-10T13:15:24Z |
| format | Article |
| id | doaj.art-6694c890c14f4495b5cb31f87beee46f |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T13:15:24Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-6694c890c14f4495b5cb31f87beee46f2023-11-21T10:26:31ZengMDPI AGMolecules1420-30492021-03-01266160910.3390/molecules26061609Chalepin and Chalepensin: Occurrence, Biosynthesis and Therapeutic PotentialLutfun Nahar0Shaymaa Al-Majmaie1Afaf Al-Groshi2Azhar Rasul3Satyajit D. Sarker4Laboratory of Growth Regulators, Institute of Experimental Botany ASCR and Palacký University, Šlechtitelů 27, 78371 Olomouc, Czech RepublicCentre for Natural Products Discovery, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool L3 3AF, UKCentre for Natural Products Discovery, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool L3 3AF, UKCell and Molecular Biology Lab, Department of Zoology, Government College University, Faisalabad 38000, PakistanCentre for Natural Products Discovery, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool L3 3AF, UKDihydrofuranocoumarin, chalepin (<b>1</b>) and furanocoumarin, chalepensin (<b>2</b>) are 3-prenylated bioactive coumarins, first isolated from the well-known medicinal plant <i>Ruta chalepensis</i> L. (Fam: Rutaceae) but also distributed in various species of the genera <i>Boenminghausenia</i>, <i>Clausena</i> and <i>Ruta</i>. The distribution of these compounds appears to be restricted to the plants of the family Rutaceae. To date, there have been a considerable number of bioactivity studies performed on coumarins <b>1</b> and <b>2</b>, which include their anticancer, antidiabetic, antifertility, antimicrobial, antiplatelet aggregation, antiprotozoal, antiviral and calcium antagonistic properties. This review article presents a critical appraisal of publications on bioactivity of these 3-prenylated coumarins in the light of their feasibility as novel therapeutic agents and investigate their natural distribution in the plant kingdom, as well as a plausible biosynthetic route.https://www.mdpi.com/1420-3049/26/6/1609<i>Ruta chalepensis</i>Rutaceaechalepinchalepensinbioactivitybiosynthesis |
| spellingShingle | Lutfun Nahar Shaymaa Al-Majmaie Afaf Al-Groshi Azhar Rasul Satyajit D. Sarker Chalepin and Chalepensin: Occurrence, Biosynthesis and Therapeutic Potential Molecules <i>Ruta chalepensis</i> Rutaceae chalepin chalepensin bioactivity biosynthesis |
| title | Chalepin and Chalepensin: Occurrence, Biosynthesis and Therapeutic Potential |
| title_full | Chalepin and Chalepensin: Occurrence, Biosynthesis and Therapeutic Potential |
| title_fullStr | Chalepin and Chalepensin: Occurrence, Biosynthesis and Therapeutic Potential |
| title_full_unstemmed | Chalepin and Chalepensin: Occurrence, Biosynthesis and Therapeutic Potential |
| title_short | Chalepin and Chalepensin: Occurrence, Biosynthesis and Therapeutic Potential |
| title_sort | chalepin and chalepensin occurrence biosynthesis and therapeutic potential |
| topic | <i>Ruta chalepensis</i> Rutaceae chalepin chalepensin bioactivity biosynthesis |
| url | https://www.mdpi.com/1420-3049/26/6/1609 |
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