Antioxidant activity and hypoglycemic effect assessment of the leaves from Syzygium cumini (L.) Skeels in Wistar rats
Syzygium cumini (L.) Skeels was adapted to the climatic conditions and soil types in Brazil. Its fruits, leaves and inner bark are used in folk medicine due to their high antioxidant, anti-inflammatory, anticarcinogenic and antidiabetic activities mainly associated with the presence of phenolic com...
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| Format: | Article |
| Language: | English |
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Universidade Estadual de Maringá
2021-02-01
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| Series: | Acta Scientiarum. Health Sciences |
| Subjects: | |
| Online Access: | https://periodicos.uem.br/ojs/index.php/ActaSciHealthSci/article/view/52931 |
| _version_ | 1818280735403933696 |
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| author | Leise Nascimento Moreira Jymmys Lopes dos Santos Lúcio Marques Vieira Souza Anderson Carlos Marçal Antônio Santos Dias Silvan Silva de Araújo Brancilene Santos Araújo Charles dos Santos Estevam |
| author_facet | Leise Nascimento Moreira Jymmys Lopes dos Santos Lúcio Marques Vieira Souza Anderson Carlos Marçal Antônio Santos Dias Silvan Silva de Araújo Brancilene Santos Araújo Charles dos Santos Estevam |
| author_sort | Leise Nascimento Moreira |
| collection | DOAJ |
| description |
Syzygium cumini (L.) Skeels was adapted to the climatic conditions and soil types in Brazil. Its fruits, leaves and inner bark are used in folk medicine due to their high antioxidant, anti-inflammatory, anticarcinogenic and antidiabetic activities mainly associated with the presence of phenolic compounds. It is estimated that at least 300 million people worldwide develop diabetes and approximately 11 million people are carriers of the disease in Brazil. The objective of this work was to evaluate the in vitro antioxidant activity, as well as the hypoglycemic action of hydroethanolic extract (HEE), the ethyl acetate (EAF) and hydromethanolic (HMF) fractions from leaves of S. cumini (L.) Skeels in rats. All assays were carried out in three replications. Data were expressed as mean ± SD and significance was evaluated by ANOVA and Bonferroni test (p < 0.05). The results indicate a significant (p < 0.05) total phenol content (207 ± 2.3 GAE mg g-1) and antioxidant activity (EC50 = 9.05 ± 0.170 µg mL-1) for EAF. HEE and its fractions showed no significant (p > 0.05) action to modulate glucose by the OGTT assay in nondiabetic mice compared to control. Thus the use of the plant against diabetes in individuals is not proven.
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| first_indexed | 2024-12-12T23:53:57Z |
| format | Article |
| id | doaj.art-669638c57cc84ceaa00b30ad15ace643 |
| institution | Directory Open Access Journal |
| issn | 1679-9291 1807-8648 |
| language | English |
| last_indexed | 2024-12-12T23:53:57Z |
| publishDate | 2021-02-01 |
| publisher | Universidade Estadual de Maringá |
| record_format | Article |
| series | Acta Scientiarum. Health Sciences |
| spelling | doaj.art-669638c57cc84ceaa00b30ad15ace6432022-12-22T00:06:37ZengUniversidade Estadual de MaringáActa Scientiarum. Health Sciences1679-92911807-86482021-02-0143110.4025/actascihealthsci.v43i1.52931Antioxidant activity and hypoglycemic effect assessment of the leaves from Syzygium cumini (L.) Skeels in Wistar ratsLeise Nascimento Moreira0Jymmys Lopes dos Santos1Lúcio Marques Vieira Souza2Anderson Carlos Marçal3Antônio Santos Dias4Silvan Silva de Araújo5Brancilene Santos Araújo6Charles dos Santos Estevam7Universidade Federal de SergipeUniversidade Federal de SergipeUniversidade Federal de Sergipe / Universidade do Estado de Minas GeraisUniversidade Federal de SergipeUniversidade Federal de SergipeUniversidade Federal de SergipeUniversidade Federal de SergipeUniversidade Federal de Sergipe Syzygium cumini (L.) Skeels was adapted to the climatic conditions and soil types in Brazil. Its fruits, leaves and inner bark are used in folk medicine due to their high antioxidant, anti-inflammatory, anticarcinogenic and antidiabetic activities mainly associated with the presence of phenolic compounds. It is estimated that at least 300 million people worldwide develop diabetes and approximately 11 million people are carriers of the disease in Brazil. The objective of this work was to evaluate the in vitro antioxidant activity, as well as the hypoglycemic action of hydroethanolic extract (HEE), the ethyl acetate (EAF) and hydromethanolic (HMF) fractions from leaves of S. cumini (L.) Skeels in rats. All assays were carried out in three replications. Data were expressed as mean ± SD and significance was evaluated by ANOVA and Bonferroni test (p < 0.05). The results indicate a significant (p < 0.05) total phenol content (207 ± 2.3 GAE mg g-1) and antioxidant activity (EC50 = 9.05 ± 0.170 µg mL-1) for EAF. HEE and its fractions showed no significant (p > 0.05) action to modulate glucose by the OGTT assay in nondiabetic mice compared to control. Thus the use of the plant against diabetes in individuals is not proven. https://periodicos.uem.br/ojs/index.php/ActaSciHealthSci/article/view/52931Syzygium cumini; oxidative stress; natural product. |
| spellingShingle | Leise Nascimento Moreira Jymmys Lopes dos Santos Lúcio Marques Vieira Souza Anderson Carlos Marçal Antônio Santos Dias Silvan Silva de Araújo Brancilene Santos Araújo Charles dos Santos Estevam Antioxidant activity and hypoglycemic effect assessment of the leaves from Syzygium cumini (L.) Skeels in Wistar rats Acta Scientiarum. Health Sciences Syzygium cumini; oxidative stress; natural product. |
| title | Antioxidant activity and hypoglycemic effect assessment of the leaves from Syzygium cumini (L.) Skeels in Wistar rats |
| title_full | Antioxidant activity and hypoglycemic effect assessment of the leaves from Syzygium cumini (L.) Skeels in Wistar rats |
| title_fullStr | Antioxidant activity and hypoglycemic effect assessment of the leaves from Syzygium cumini (L.) Skeels in Wistar rats |
| title_full_unstemmed | Antioxidant activity and hypoglycemic effect assessment of the leaves from Syzygium cumini (L.) Skeels in Wistar rats |
| title_short | Antioxidant activity and hypoglycemic effect assessment of the leaves from Syzygium cumini (L.) Skeels in Wistar rats |
| title_sort | antioxidant activity and hypoglycemic effect assessment of the leaves from syzygium cumini l skeels in wistar rats |
| topic | Syzygium cumini; oxidative stress; natural product. |
| url | https://periodicos.uem.br/ojs/index.php/ActaSciHealthSci/article/view/52931 |
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